Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model

by Emily Locke, Yevel Flores-Garcia, Bryan T. Mayer, Randall S. MacGill, Bhavesh Borate, Berenice Salgado-Jimenez, Monica W. Gerber, Shamika Mathis-Torres, Sarah Shapiro, C. Richter King, Fidel Zavala
Published 2024-02-01

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

by Nicholas J. Tursi, Sophia M. Reeder, Yevel Flores-Garcia, Mamadou A. Bah, Shamika Mathis-Torres, Berenice Salgado-Jimenez, Rianne Esquivel, Ziyang Xu, Jacqueline D. Chu, Laurent Humeau, Ami Patel, Fidel Zavala, David B. Weiner
Published 2022-08-01

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection

by Manuela C. Aguirre-Botero, Lawrence T. Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J. Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W. Bowyer, Fidel Zavala, Azza H. Idris, Joseph R. Francica, Robert A. Seder, Rogerio Amino
Published 2023-07-01

Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein

by Elaine Thai, Rajagopal Murugan, Špela Binter, Clare Burn Aschner, Katherine Prieto, Audrey Kassardjian, Anna S. Obraztsova, Ryu Won Kang, Yevel Flores-Garcia, Shamika Mathis-Torres, Kan Li, Gillian Q. Horn, Richard H.C. Huntwork, Judith M. Bolscher, Marloes H.C. de Bruijni, Robert Sauerwein, S. Moses Dennison, Georgia D. Tomaras, Fidel Zavala, Paul Kellam, Hedda Wardemann, Jean-Philippe Julien
Published 2023-11-01