The Dynamics of Somatic Mutagenesis During Life in Humans

by Freek Manders, Ruben van Boxtel, Sjors Middelkamp
Published 2021-12-01

Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells

by Freek Manders, Jip van Dinter, Ruben van Boxtel
Published 2022-12-01

A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs

by Yun Yu, Freek Manders, Guy C. M. Grinwis, Martien A. M. Groenen, Richard P. M. A. Crooijmans
Published 2022-09-01

MutationalPatterns: the one stop shop for the analysis of mutational processes

by Freek Manders, Arianne M. Brandsma, Jurrian de Kanter, Mark Verheul, Rurika Oka, Markus J. van Roosmalen, Bastiaan van der Roest, Arne van Hoeck, Edwin Cuppen, Ruben van Boxtel
Published 2022-02-01

Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells in vivo

by Karlijn A.L. Hasaart, Freek Manders, Joske Ubels, Mark Verheul, Markus J. van Roosmalen, Niels M. Groenen, Rurika Oka, Ewart Kuijk, Susana M. Chuva de Sousa Lopes, Ruben van Boxtel
Published 2022-02-01

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

by Michael T Meister, Marian J A Groot Koerkamp, Terezinha deSouza, Willemijn B Breunis, Ewa Frazer‐Mendelewska, Mariël Brok, Jeff DeMartino, Freek Manders, Camilla Calandrini, Hinri H D Kerstens, Alex Janse, M Emmy M Dolman, Selma Eising, Karin P S Langenberg, Marc vanTuil, Rutger R G Knops, Sheila Terwisscha vanScheltinga, Laura S Hiemcke‐Jiwa, Uta Flucke, Johannes H M Merks, Max M vanNoesel, Bastiaan B J Tops, Jayne Y Hehir‐Kwa, Patrick Kemmeren, Jan J Molenaar, Marc van deWetering, Ruben vanBoxtel, Jarno Drost, Frank C P Holstege
Published 2022-10-01