The development and validation of prognostic models for overall survival in the presence of missing data in the training dataset: a strategy with a detailed example

by Kara-Louise Royle, David A. Cairns
Published 2021-08-01

How is overall survival assessed in randomised clinical trials in cancer and are subsequent treatment lines considered? A systematic review

by Kara-Louise Royle, David Meads, Jennifer K. Visser-Rogers, Ian R. White, David A. Cairns
Published 2023-11-01

The future for diagnostic tests of acute kidney injury in critical care: evidence synthesis, care pathway analysis and research prioritisation

by Peter S Hall, Elizabeth D Mitchell, Alison F Smith, David A Cairns, Michael Messenger, Michelle Hutchinson, Judy Wright, Karen Vinall-Collier, Claire Corps, Patrick Hamilton, David Meads, Andrew Lewington
Published 2018-05-01

NuMA overexpression in epithelial ovarian cancer.

by Anke Brüning-Richardson, Jaqueline Bond, Rawiah Alsiary, Julie Richardson, David A Cairns, Luci McCormac, Richard Hutson, Philip A Burns, Nafisa Wilkinson, Geoff D Hall, Ewan E Morrison, Sandra M Bell
Published 2012-01-01

Personalised reprogramming to prevent progressive pacemaker-related left ventricular dysfunction: A phase II randomised, controlled clinical trial.

by Maria F Paton, John Gierula, Judith E Lowry, David A Cairns, Kieran Bose Rosling, Charlotte A Cole, Melanie McGinlay, Sam Straw, Rowena Byrom, Richard M Cubbon, Mark T Kearney, Klaus K Witte
Published 2021-01-01

The role of ixazomib as an augmented conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT consolidation and maintenance strategy in patients wi...

by Alina Striha, A. John Ashcroft, Anna Hockaday, David A. Cairns, Karen Boardman, Gwen Jacques, Cathy Williams, John A. Snowden, Mamta Garg, Jamie Cavenagh, Kwee Yong, Mark T. Drayson, Roger Owen, Mark Cook, Gordon Cook
Published 2018-03-01

How to Simplify the Evaluation of Newly Introduced Chemotherapeutic Interventions in Myeloma

by Treen Carson Michael Morris, Mary B. Drake, Paul J. Kettle, Tracey McGuigan, Maeve Leahy, Michael O’Dwyer, Helen Enright, Tanya O’Shea, Rakesh Popat, Heather E. Oakervee, Kwee Yong, Jamie D. Cavenagh, David A. Cairns, Alberto Alvarez-Iglesias, Gordon Cook
Published 2021-02-01

Chromosome 1q21 abnormalities refine outcome prediction in patients with multiple myeloma - a meta-analysis of 2,596 trial patients

by Niels Weinhold, Hans J. Salwender, David A. Cairns, Marc S. Raab, George Waldron, Igor W. Blau, Uta Bertsch, Thomas Hielscher, Gareth J. Morgan, Anna Jauch, Faith E. Davies, Mathias Hänel, Gordon Cook, Christoph Scheid, Richard Houlston, Hartmut Goldschmidt, Graham Jackson, Martin F. Kaiser
Published 2021-06-01

Maintenance lenalidomide in newly diagnosed transplant eligible and non-eligible myeloma patients; profiling second primary malignancies in 4358 patients treated in the Myeloma XI...

by John R. Jones, David A. Cairns, Tom Menzies, Charlotte Pawlyn, Faith E. Davies, Rachel Sigsworth, Annamaria Brioli, Matthew W. Jenner, Martin F. Kaiser, Catherine Olivier, Molly Reed, Mark T. Drayson, Roger G. Owen, Kevin D. Boyd, Gordon Cook, Gareth J. Morgan, Graham H. Jackson
Published 2023-08-01

Randomised, placebo-controlled, phase 3 trial of the effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after...

by Helen Marshall, Mark A Hull, David A Cairns, Andrew T Chan, Mingyang Song, Robert Jones, Peter S Hall, Catherine Moriarty, David A Drew, Wendy S Garrett, Giles J Toogood, Paul M Loadman, Andrew J Cockbain, Omer Yilmaz, Pei Loo Ow, Sharon Ruddock, Tim Brend, Alexandra F Smith, Fiona Collinson
Published 2023-11-01

NET-02: a randomised, non-comparative, phase II trial of nal-IRI/5-FU or docetaxel as second-line therapy in patients with progressive poorly differentiated extra-pulmonary neuroen...

by Mairéad G. McNamara, Jayne Swain, Zoe Craig, Rohini Sharma, Olusola Faluyi, Jonathan Wadsley, Carys Morgan, Lucy R. Wall, Ian Chau, Nick Reed, Debashis Sarker, Jane Margetts, Daniel Krell, Judith Cave, Sharmila Sothi, Alan Anthoney, Christopher Bell, Alkesh Patel, Jamie B. Oughton, David A. Cairns, Wasat Mansoor, Angela Lamarca, Richard A. Hubner, Juan W. Valle
Published 2023-06-01

Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly di...

by John R. Jones, Niels Weinhold, Cody Ashby, Brian A. Walker, Chris Wardell, Charlotte Pawlyn, Leo Rasche, Lorenzo Melchor, David A. Cairns, Walter M. Gregory, David Johnson, Dil B. Begum, Sidra Ellis, Amy L. Sherborne, Gordon Cook, Martin F. Kaiser, Mark T. Drayson, Roger G. Owen, Graham H. Jackson, Faith E. Davies, Mel Greaves, Gareth J. Morgan
Published 2019-07-01

Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III...

by Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson
Published 2022-06-01

Risk and response adapted therapy following autologous stem cell transplant in patients with newly diagnosed multiple myeloma (RADAR (UK-MRA Myeloma XV Trial): study protocol for a...

by Roger Owen, Mark Cook, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Kwee Yong, Guy Pratt, Martin Kaiser, Karthik Ramasamy, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Anna Hockaday, Ruth de Tute, Bryony Dawkins, Mark Drayson, Jonathan Sive, Holger W Auner, Sergio Quezada, Lorna Barnard, Rhiannon Lambkin, Andrea Paterson, Mike Chapman, Rakesh Popat, Ceri Bygrave, Andrew Chantry, Samir Asher
Published 2022-11-01

Carfilzomib, lenalidomide, dexamethasone, and cyclophosphamide (KRdc) as induction therapy for transplant-eligible, newly diagnosed multiple myeloma patients (Myeloma XI+): Interim...

by Graham H Jackson, Charlotte Pawlyn, David A Cairns, Ruth M de Tute, Anna Hockaday, Corinne Collett, John R Jones, Bhuvan Kishore, Mamta Garg, Cathy D Williams, Kamaraj Karunanithi, Jindriska Lindsay, Alberto Rocci, John A Snowden, Matthew W Jenner, Gordon Cook, Nigel H Russell, Mark T Drayson, Walter M Gregory, Martin F Kaiser, Roger G Owen, Faith E Davies, Gareth J Morgan, UK NCRI Haemato-oncology Clinical Studies Group
Published 2021-01-01

Lenalidomide before and after autologous stem cell transplantation for transplant-eligible patients of all ages in the randomized, phase III, Myeloma XI trial

by Graham H. Jackson, Faith E. Davies, Charlotte Pawlyn, David A. Cairns, Alina Striha, Corinne Collett, Anna Waterhouse, John R. Jones, Bhuvan Kishore, Mamta Garg, Cathy D. Williams, Kamaraj Karunanithi, Jindriska Lindsay, David Allotey, Salim Shafeek, Matthew W. Jenner, Gordon Cook, Nigel H. Russell, Martin F. Kaiser, Mark T. Drayson, Roger G. Owen, Walter M. Gregory, Gareth J. Morgan, UK NCRI Haematological Oncology Clinical Studies Group
Published 2020-06-01

Methods for the evaluation of biomarkers in patients with kidney and liver diseases: multicentre research programme including ELUCIDATE RCT

by Peter J Selby, Rosamonde E Banks, Walter Gregory, Jenny Hewison, William Rosenberg, Douglas G Altman, Jonathan J Deeks, Christopher McCabe, Julie Parkes, Catharine Sturgeon, Douglas Thompson, Maureen Twiddy, Janine Bestall, Joan Bedlington, Tilly Hale, Jacqueline Dinnes, Marc Jones, Andrew Lewington, Michael P Messenger, Vicky Napp, Alice Sitch, Sudeep Tanwar, Naveen S Vasudev, Paul Baxter, Sue Bell, David A Cairns, Nicola Calder, Neil Corrigan, Francesco Del Galdo, Peter Heudtlass, Nick Hornigold, Claire Hulme, Michelle Hutchinson, Carys Lippiatt, Tobias Livingstone, Roberta Longo, Matthew Potton, Stephanie Roberts, Sheryl Sim, Sebastian Trainor, Matthew Welberry Smith, James Neuberger, Douglas Thorburn, Paul Richardson, John Christie, Neil Sheerin, William McKane, Paul Gibbs, Anusha Edwards, Naeem Soomro, Adebanji Adeyoju, Grant D Stewart, David Hrouda
Published 2018-06-01