In vivo CRISPR screens reveal potent driver mutations in head and neck cancers

by Sampath Kumar Loganathan, Daniel Schramek
Published 2020-07-01

A CRISPR Path to Finding Vulnerabilities and Solving Drug Resistance: Targeting the Diverse Cancer Landscape and Its Ecosystem

by Benjamin McLean, Aji Istadi, Teleri Clack, Mezzalina Vankan, Daniel Schramek, G. Gregory Neely, Marina Pajic
Published 2022-12-01

ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

by Hanseul Yang, Daniel Schramek, Rene C Adam, Brice E Keyes, Ping Wang, Deyou Zheng, Elaine Fuchs
Published 2015-11-01

Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?

by Igor Araujo Vieira, Igor Araujo Vieira, Tiago Finger Andreis, Tiago Finger Andreis, Bruna Vieira Fernandes, Bruna Vieira Fernandes, Maria Isabel Achatz, Gabriel S. Macedo, Gabriel S. Macedo, Daniel Schramek, Daniel Schramek, Patricia Ashton-Prolla, Patricia Ashton-Prolla, Patricia Ashton-Prolla
Published 2021-02-01

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

by Krzysztof Chylinski, Maria Hubmann, Ruth E. Hanna, Connor Yanchus, Georg Michlits, Esther C. H. Uijttewaal, John Doench, Daniel Schramek, Ulrich Elling
Published 2019-11-01

The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma

by Yue Yan, Marc-Andre Gauthier, Ahmad Malik, Iosifina Fotiadou, Michael Ostrovski, Dzana Dervovic, Logine Ghadban, Ricky Tsai, Gerald Gish, Sampath Kumar Loganathan, Daniel Schramek
Published 2023-01-01

Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas

by Keren Isaev, Lingyan Jiang, Shuai Wu, Christian A. Lee, Valérie Watters, Victoire Fort, Ricky Tsai, Fiona J. Coutinho, Samer M.I. Hussein, Jie Zhang, Jinsong Wu, Peter B. Dirks, Daniel Schramek, Jüri Reimand
Published 2021-10-01

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

by Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux
Published 2020-07-01

In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer

by Sebastien Martinez, Shifei Wu, Michael Geuenich, Ahmad Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N. Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G. Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran Campbell, Ulrich Elling, Daniel Schramek
Published 2024-06-01

Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy

by Iris Uribesalgo, David Hoffmann, Yin Zhang, Anoop Kavirayani, Jelena Lazovic, Judit Berta, Maria Novatchkova, Tsung‐Pin Pai, Reiner A Wimmer, Viktória László, Daniel Schramek, Rezaul Karim, Luigi Tortola, Sumit Deswal, Lisa Haas, Johannes Zuber, Miklós Szűcs, Keiji Kuba, Balazs Dome, Yihai Cao, Bernhard J Haubner, Josef M Penninger
Published 2019-08-01

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

by Dzana Dervovic, Ahmad A. Malik, Edward L. Y. Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni-Zadeh, Dagmar Krenbek, Sebastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M. Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath K. Loganathan, Jongbok Lee, Li Zhang, Cynthia Guidos, Jeffrey Wrana, Arschang Valipour, Philippe P. Roux, Jüri Reimand, Hartland W. Jackson, Daniel Schramek
Published 2023-05-01

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

by YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Published 2024-04-01

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

by Dzana Dervovic, Ahmad A. Malik, Edward L. Y. Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni-Zadeh, Dagmar Krenbek, Sebastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M. Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath K. Loganathan, Jongbok Lee, Li Zhang, Cynthia Guidos, Jeffrey Wrana, Arschang Valipour, Philippe P. Roux, Jüri Reimand, Hartland W. Jackson, Daniel Schramek
Published 2023-09-01

Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages

by Hyeyeon Kim, Kazeera Aliar, Pirashaanthy Tharmapalan, Curtis W. McCloskey, Abhijith Kuttanamkuzhi, Barbara T. Grünwald, Luis Palomero, Mathepan J. Mahendralingam, Matthew Waas, Arvind S. Mer, Mitchell J. Elliott, Bowen Zhang, Khalid N. Al-Zahrani, Ellen R. Langille, Michael Parsons, Swami Narala, Stefan Hofer, Paul D. Waterhouse, Razqallah Hakem, Benjamin Haibe-Kains, Thomas Kislinger, Daniel Schramek, David W. Cescon, Miquel A. Pujana, Hal K. Berman, Rama Khokha
Published 2023-11-01

Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages

by Hyeyeon Kim, Kazeera Aliar, Pirashaanthy Tharmapalan, Curtis W. McCloskey, Abhijith Kuttanamkuzhi, Barbara T. Grünwald, Luis Palomero, Mathepan J. Mahendralingam, Matthew Waas, Arvind S. Mer, Mitchell J. Elliott, Bowen Zhang, Khalid N. Al-Zahrani, Ellen R. Langille, Michael Parsons, Swami Narala, Stefan Hofer, Paul D. Waterhouse, Razqallah Hakem, Benjamin Haibe-Kains, Thomas Kislinger, Daniel Schramek, David W. Cescon, Miquel A. Pujana, Hal K. Berman, Rama Khokha
Published 2023-10-01