Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens.

by Mudra Hegde, Christine Strand, Ruth E Hanna, John G Doench
Published 2018-01-01

Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to...

by Cai M. Roberts, Mehida Rojas-Alexandre, Ruth E. Hanna, Z. Ping Lin, Elena S. Ratner
Published 2023-08-01

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

by Krzysztof Chylinski, Maria Hubmann, Ruth E. Hanna, Connor Yanchus, Georg Michlits, Esther C. H. Uijttewaal, John Doench, Daniel Schramek, Ulrich Elling
Published 2019-11-01

Genetic screens in isogenic mammalian cell lines without single cell cloning

by Peter C. DeWeirdt, Annabel K. Sangree, Ruth E. Hanna, Kendall R. Sanson, Mudra Hegde, Christine Strand, Nicole S. Persky, John G. Doench
Published 2020-02-01

Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2

by Annabel K. Sangree, Audrey L. Griffith, Zsofia M. Szegletes, Priyanka Roy, Peter C. DeWeirdt, Mudra Hegde, Abby V. McGee, Ruth E. Hanna, John G. Doench
Published 2022-03-01

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

by Kendall R. Sanson, Ruth E. Hanna, Mudra Hegde, Katherine F. Donovan, Christine Strand, Meagan E. Sullender, Emma W. Vaimberg, Amy Goodale, David E. Root, Federica Piccioni, John G. Doench
Published 2018-12-01

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.

by Madison S Strine, Wesley L Cai, Jin Wei, Mia Madel Alfajaro, Renata B Filler, Scott B Biering, Sylvia Sarnik, Ryan D Chow, Ajinkya Patil, Kasey S Cervantes, Clayton K Collings, Peter C DeWeirdt, Ruth E Hanna, Kevin Schofield, Christopher Hulme, Silvana Konermann, John G Doench, Patrick D Hsu, Cigall Kadoch, Qin Yan, Craig B Wilen
Published 2023-06-01