Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors

by Stephane Angers
Published 2021-04-01

Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

by Renyue Bao, Tania Christova, Siyuan Song, Stephane Angers, Xiaojun Yan, Liliana Attisano
Published 2012-01-01

Identification of Novel Smoothened Ligands Using Structure-Based Docking.

by Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers
Published 2016-01-01

The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

by Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux
Published 2023-12-01

Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.

by Sarah H Louie, Xiao Yong Yang, William H Conrad, Jeanot Muster, Stephane Angers, Randall T Moon, Benjamin N R Cheyette
Published 2009-01-01

A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response

by Lingling Zhang, Md. Abedin, Ha-Neul Jo, Jacklyn Levey, Quynh Chau Dinh, Zhe Chen, Stephane Angers, Harald J. Junge
Published 2023-08-01

The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.

by Brenden Hurley, Donghyuk Lee, Adam Mott, Michael Wilton, Jun Liu, Yulu C Liu, Stephane Angers, Gitta Coaker, David S Guttman, Darrell Desveaux
Published 2014-01-01

Identifying chemogenetic interactions from CRISPR screens with drugZ

by Medina Colic, Gang Wang, Michal Zimmermann, Keith Mascall, Megan McLaughlin, Lori Bertolet, W. Frank Lenoir, Jason Moffat, Stephane Angers, Daniel Durocher, Traver Hart
Published 2019-08-01

The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity.

by Junfeng Han, Ming Zhang, Sean Froese, Feihan F Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyi Huang, Weiping Jia, Stéphane Angers, Michael B Wheeler, Li Wei
Published 2015-01-01

Rapid On-Cell Selection of High-Performance Human Antibodies

by David N. Philpott, Surath Gomis, Hansen Wang, Randy Atwal, Abdellali Kelil, Tanja Sack, Brandon Morningstar, Chris Burnie, Edward H. Sargent, Stephane Angers, Sachdev Sidhu, Shana O. Kelley
Published 2021-12-01

A GENOME-WIDE CRISPR/CAS9 SCREENING IDENTIFIES GENETIC MODIFIERS OF ΑLPHA SYNUCLEIN AGGREGATES UPTAKE

by Benoît Vanderperre, Amitha Muraleedharan, Frédérique Larroquette, Rony Chidiac, Charlotte Tardif, Nishani Rajakulendran, Graham Macleod, Roxanne Larivière, Esther Del Cid Pellitero, Rhalena Thomas, Thomas Durcan, Stephane Angers, Edward Fon
Published 2023-10-01

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

by Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux
Published 2022-10-01

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

by Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu
Published 2019-08-01

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis

by Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton
Published 2024-05-01

A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.

by Amy Huei-Yi Lee, Brenden Hurley, Corinna Felsensteiner, Carmen Yea, Wenzislava Ckurshumova, Verena Bartetzko, Pauline W Wang, Van Quach, Jennifer D Lewis, Yulu C Liu, Frederik Börnke, Stephane Angers, Andrew Wilde, David S Guttman, Darrell Desveaux
Published 2012-02-01

The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs

by John D. Laver, Jimmy Ly, Allison K. Winn, Angelo Karaiskakis, Sichun Lin, Kun Nie, Giulia Benic, Nima Jaberi-Lashkari, Wen Xi Cao, Alireza Khademi, J. Timothy Westwood, Sachdev S. Sidhu, Quaid Morris, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz
Published 2020-03-01

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

by Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux
Published 2020-07-01

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells

by Graham MacLeod, Danielle A. Bozek, Nishani Rajakulendran, Vernon Monteiro, Moloud Ahmadi, Zachary Steinhart, Michelle M. Kushida, Helen Yu, Fiona J. Coutinho, Florence M.G. Cavalli, Ian Restall, Xiaoguang Hao, Traver Hart, H. Artee Luchman, Samuel Weiss, Peter B. Dirks, Stephane Angers
Published 2019-04-01

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

by Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar
Published 2017-03-01

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

by Paul Guilhamon, Charles Chesnelong, Michelle M Kushida, Ana Nikolic, Divya Singhal, Graham MacLeod, Seyed Ali Madani Tonekaboni, Florence MG Cavalli, Christopher Arlidge, Nishani Rajakulendran, Naghmeh Rastegar, Xiaoguang Hao, Rozina Hassam, Laura J Smith, Heather Whetstone, Fiona J Coutinho, Bettina Nadorp, Katrina I Ellestad, H Artee Luchman, Jennifer Ai-wen Chan, Molly S Shoichet, Michael D Taylor, Benjamin Haibe-Kains, Samuel Weiss, Stephane Angers, Marco Gallo, Peter B Dirks, Mathieu Lupien
Published 2021-01-01