Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects

by Marcela Krečmerová, Pavel Majer, Rana Rais, Barbara S. Slusher
Published 2022-05-01

Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats.

by Michelle C Potter, Krystyna M Wozniak, Noelle Callizot, Barbara S Slusher
Published 2014-01-01

Clinical development of metabolic inhibitors for oncology

by Kathryn M. Lemberg, Sadakatali S. Gori, Takashi Tsukamoto, Rana Rais, Barbara S. Slusher
Published 2022-01-01

Development of a primary microglia screening assay and its use to characterize inhibition of system xc- by erastin and its analogs

by Mariana Figuera-Losada, Ajit G. Thomas, Marigo Stathis, Brent R. Stockwell, Camilo Rojas, Barbara S. Slusher
Published 2017-03-01

Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons

by Sehmus Tohumeken, Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher, Norman J. Haughey
Published 2023-02-01

Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain

by Zhi Zhang, Bassam Bassam, Ajit G. Thomas, Monica Williams, Jinhuan Liu, Elizabeth Nance, Camilo Rojas, Barbara S. Slusher, Sujatha Kannan
Published 2016-10-01

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration.

by Rana Rais, Krystyna Wozniak, Ying Wu, Minae Niwa, Marigo Stathis, Jesse Alt, Marc Giroux, Akira Sawa, Camilo Rojas, Barbara S Slusher
Published 2015-01-01

High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.

by Ajit G Thomas, Rita Sattler, Karen Tendyke, Kara A Loiacono, Hans Hansen, Vishal Sahni, Yutaka Hashizume, Camilo Rojas, Barbara S Slusher
Published 2015-01-01

Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice

by Benjamin J. Bell, Kristen R. Hollinger, Pragney Deme, Shinji Sakamoto, Yuto Hasegawa, David Volsky, Atsushi Kamiya, Norman Haughey, Xiaolei Zhu, Barbara S. Slusher
Published 2022-08-01

Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

by Dibyadeep Datta, Shannon N. Leslie, Elizabeth Woo, Nishita Amancharla, Ayah Elmansy, Miguel Lepe, Adam P. Mecca, Barbara S. Slusher, Angus C. Nairn, Amy F. T. Arnsten
Published 2021-11-01

Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR‐Driven Lung Cancer

by Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Shizuko Sei, Robert H. Shoemaker, Ronald A. Lubet, Luis M. Montuenga, Yian Wang, Barbara S. Slusher, Ming You
Published 2022-09-01

D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II

by Sadakatali S. Gori, Ajit G. Thomas, Arindom Pal, Robyn Wiseman, Dana V. Ferraris, Run-duo Gao, Ying Wu, Jesse Alt, Takashi Tsukamoto, Barbara S. Slusher, Rana Rais
Published 2022-09-01

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma

by Allison R. Hanaford, Jesse Alt, Rana Rais, Sabrina Z. Wang, Harpreet Kaur, Daniel L.J. Thorek, Charles G. Eberhart, Barbara S. Slusher, Allison M. Martin, Eric H. Raabe
Published 2019-10-01

T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade

by Kyungho Lee, Elizabeth A. Thompson, Sepideh Gharaie, Chirag H. Patel, Johanna T. Kurzhagen, Phillip M. Pierorazio, Lois J. Arend, Ajit G. Thomas, Sanjeev Noel, Barbara S. Slusher, Hamid Rabb
Published 2023-06-01

Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways

by Khoa Pham, Allison R. Hanaford, Brad A. Poore, Micah J. Maxwell, Heather Sweeney, Akhila Parthasarathy, Jesse Alt, Rana Rais, Barbara S. Slusher, Charles G. Eberhart, Eric H. Raabe
Published 2022-03-01

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

by Sadiya Parveen, Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin Koleske, Robert D. Leone, Rana Rais, Jonathan D. Powell, John R. Murphy, Barbara S. Slusher, William R. Bishai
Published 2023-11-01

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

by Scott J Dixon, Darpan N Patel, Matthew Welsch, Rachid Skouta, Eric D Lee, Miki Hayano, Ajit G Thomas, Caroline E Gleason, Nicholas P Tatonetti, Barbara S Slusher, Brent R Stockwell
Published 2014-05-01

Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice

by Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D. J. Huizar, Silvia Picciolini, Ajit G. Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M. Kannan, Marzia Bedoni, Rana Rais, Barbara S. Slusher
Published 2023-09-01

High-affinity Near-infrared Fluorescent Small-molecule Contrast Agents for In Vivo Imaging of Prostate-specific Membrane Antigen

by Valerie Humblet, Rena Lapidus, Larry R. Williams, Takashi Tsukamoto, Camilo Rojas, Pavel Majer, Bunda Hin, Shunsuke Ohnishi, Alec M. De Grand, Atif Zaheer, Jürgen T. Renze, Akira Nakayama, Barbara S. Slusher, John V. Frangioni
Published 2005-10-01

Preventing Allograft Rejection by Targeting Immune Metabolism

by Chen-Fang Lee, Ying-Chun Lo, Chih-Hsien Cheng, Georg J. Furtmüller, Byoungchol Oh, Vinicius Andrade-Oliveira, Ajit G. Thomas, Caitlyn E. Bowman, Barbara S. Slusher, Michael J. Wolfgang, Gerald Brandacher, Jonathan D. Powell
Published 2015-10-01