Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials

by Christopher H. Van Dyck, Ryan S. O'Dell, Adam P. Mecca
Published 2023-04-01

Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease

by Yihuan Lu, Takuya Toyonaga, Mika Naganawa, Jean-Dominique Gallezot, Ming-Kai Chen, Adam P. Mecca, Christopher H. van Dyck, Richard E. Carson
Published 2021-09-01

Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

by Dibyadeep Datta, Shannon N. Leslie, Elizabeth Woo, Nishita Amancharla, Ayah Elmansy, Miguel Lepe, Adam P. Mecca, Barbara S. Slusher, Angus C. Nairn, Amy F. T. Arnsten
Published 2021-11-01

Dementia risk analysis using temporal event modeling on a large real-world dataset

by R. Andrew Taylor, Aidan Gilson, Ling Chi, Adrian D. Haimovich, Anna Crawford, Cynthia Brandt, Phillip Magidson, James M. Lai, Scott Levin, Adam P. Mecca, Ula Hwang
Published 2023-12-01

A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease

by Christopher H. van Dyck, Adam P. Mecca, Ryan S. O’Dell, Hugh H. Bartlett, Nina G. Diepenbrock, Yiyun Huang, Mary E. Hamby, Michael Grundman, Susan M. Catalano, Anthony O. Caggiano, Richard E. Carson
Published 2024-01-01

Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis

by Xiaotian T. Fang, Takuya Toyonaga, Ansel T. Hillmer, David Matuskey, Sophie E. Holmes, Rajiv Radhakrishnan, Adam P. Mecca, Christopher H. van Dyck, Deepak Cyril D'Souza, Irina Esterlis, Patrick D. Worhunsky, Richard E. Carson
Published 2021-08-01

Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease

by Juan Joseph Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh Bartlett, Hye Sun Kim, Serhan Unlu, Lais Osmani, Min Sun Shin, Richard Bucala, Christopher H. van Dyck, Heather Allore, Adam P. Mecca, Sungyong You, Insoo Kang
Published 2023-12-01

Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET

by Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck
Published 2021-09-01

Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease

by Ryan S. O'Dell, Albert Higgins-Chen, Dhruva Gupta, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Gessica Ni, Anna Chupak, Wenzhen Zhao, Elaheh Salardini, Nabeel B. Nabulsi, Yiyun Huang, Amy F.T. Arnsten, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca
Published 2023-01-01

PET imaging of mGluR5 in Alzheimer’s disease

by Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck
Published 2020-01-01

Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

by Ryan S. O’Dell, Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Tyler A. Godek, Joanna E. Harris, Hugh H. Bartlett, Emmie R. Banks, Victoria L. Kominek, Wenzhen Zhao, Nabeel B. Nabulsi, Jim Ropchan, Yunpeng Ye, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck
Published 2021-01-01