From bench to patient: model systems in drug discovery

by Matthew D. Breyer, A. Thomas Look, Alessandra Cifra
Published 2015-10-01

Targeting ganglioneuromas with mTOR inhibitors

by Ting Tao, Hui Shi, Adam D. Durbin, A. Thomas Look
Published 2021-01-01

The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.

by Jinhua Quan, Guillaume Adelmant, Jarrod A Marto, A Thomas Look, Timur Yusufzai
Published 2014-01-01

Zebrafish sperm cryopreservation with N,N-dimethylacetamide

by John P. Morris IV, Stephane Berghmans, David Zahrieh, Donna S. Neuberg, John P. Kanki, A. Thomas Look
Published 2003-11-01

ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors

by Lu Wang, Tze King Tan, Hyoju Kim, Dennis Kappei, Shi Hao Tan, A. Thomas Look, Takaomi Sanda
Published 2023-12-01

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

by Felix Oppel, Ting Tao, Hui Shi, Kenneth N Ross, Mark W Zimmerman, Shuning He, Guangxiang Tong, Jon C Aster, A Thomas Look
Published 2019-04-01

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

by Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
Published 2020-08-01

p27KIP1 Deletions in Childhood Acute Lymphoblastic Leukemia

by Hiroaki Komuro, Marcus B. Valentine, Jeffrey E. Rubnitz, Midori Saito, Susana C. Raimondi, Andrew J. Carroll, Taolin Yi, Charles J. Sherr, A. Thomas Look
Published 1999-08-01

Detection of MYCN Gene Amplification in Neuroblastoma by Fluorescence In Situ Hybridization: A Pediatric Oncology Group Study

by Prasad Mathew, Marcus B. Valentine, Laura C. Bowman, Susan T. Rowe, Michael B. Nash, Virginia A. Valentine, Susan L. Cohn, Robert P. Castleberry, Garrett M. Brodeur, A. Thomas Look
Published 2001-01-01

Lack of Homozygously Inactivated p73 in Single-Copy MYCN Primary Neuroblastomas and Neuroblastoma Cell Lines

by Xiao-Tang Kong, Virginia A. Valentine, Susan T. Rowe, Marcus B. Valentine, Susan T. Ragsdale, Bart G. Jones, Deborah A. Wilkinson, Garrett M. Brodeur, Susan L. Cohn, A. Thomas Look
Published 1999-04-01

Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish

by Evisa Gjini, Chang-Bin Jing, Ashley T. Nguyen, Deepak Reyon, Emma Gans, Michiel Kesarsing, Joshua Peterson, Olga Pozdnyakova, Scott J. Rodig, Marc R. Mansour, Keith Joung, A. Thomas Look
Published 2019-05-01

Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays.

by Rani E George, Edward F Attiyeh, Shuli Li, Lisa A Moreau, Donna Neuberg, Cheng Li, Edward A Fox, Matthew Meyerson, Lisa Diller, Paolo Fortina, A Thomas Look, John M Maris
Published 2007-02-01

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

by Xiaoling Zhang, Zhiwei Dong, Cheng Zhang, Choong Yong Ung, Shuning He, Ting Tao, Andre M. Oliveira, Alexander Meves, Baoan Ji, A. Thomas Look, Hu Li, Benjamin G. Neel, Shizhen Zhu
Published 2017-03-01

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.

by Shelly Sorrells, Seth Carbonneau, Erik Harrington, Aye T Chen, Bridgid Hast, Brett Milash, Ujwal Pyati, Michael B Major, Yi Zhou, Leonard I Zon, Rodney A Stewart, A Thomas Look, Cicely Jette
Published 2012-01-01

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

by Qin Tang, John C. Moore, Myron S. Ignatius, Inês M. Tenente, Madeline N. Hayes, Elaine G. Garcia, Nora Torres Yordán, Caitlin Bourque, Shuning He, Jessica S. Blackburn, A. Thomas Look, Yariv Houvras, David M. Langenau
Published 2016-01-01

MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

by Stefan Heinrichs, Lillian F Conover, Carlos E Bueso-Ramos, Outi Kilpivaara, Kristen Stevenson, Donna Neuberg, Mignon L Loh, Wen-Shu Wu, Scott J Rodig, Guillermo Garcia-Manero, Hagop M Kantarjian, A Thomas Look
Published 2013-07-01

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

by Shuning He, Marc R Mansour, Mark W Zimmerman, Dong Hyuk Ki, Hillary M Layden, Koshi Akahane, Evisa Gjini, Eric D de Groh, Antonio R Perez-Atayde, Shizhen Zhu, Jonathan A Epstein, A Thomas Look
Published 2016-04-01

Small genomic insertions form enhancers that misregulate oncogenes

by Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Published 2017-02-01

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors

by Linda Zuurbier, Alejandro Gutierrez, Charles G. Mullighan, Kirsten Canté-Barrett, A. Olivier Gevaert, Johan de Rooi, Yunlei Li, Willem K. Smits, Jessica G.C.A.M. Buijs-Gladdines, Edwin Sonneveld, A. Thomas Look, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink
Published 2014-01-01

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

by Nina Weichert-Leahey, Hui Shi, Ting Tao, Derek A. Oldridge, Adam D. Durbin, Brian J. Abraham, Mark W. Zimmerman, Shizhen Zhu, Andrew C. Wood, Deepak Reyon, J. Keith Joung, Richard A. Young, Sharon J. Diskin, John M. Maris, A. Thomas Look
Published 2023-05-01