Metastatic penile carcinoma associated with convergent gain-of-function mutations in NOTCH1

by Sabina Signoretti, Jon C. Aster
Published 2018-03-01

A Novel SEC22B-NOTCH2 Fusion in Chronic Lymphocytic Leukemia

by Rory Crotty, Dora Dias-Santagata, Jon C. Aster, Valentina Nardi
Published 2020-09-01

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

by Sung Hee Choi, Eric Severson, Warren S Pear, Xiaole S Liu, Jon C Aster, Stephen C Blacklow
Published 2017-01-01

Gene expression profiling distinguishes prefibrotic from overtly fibrotic myeloproliferative neoplasms and identifies disease subsets with distinct inflammatory signatures.

by Waihay J Wong, Michele Baltay, Annaliese Getz, Kit Fuhrman, Jon C Aster, Robert P Hasserjian, Olga Pozdnyakova
Published 2019-01-01

Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content

by Yanyu Zhao, Anahita Pilvar, Anup Tank, Hannah Peterson, John Jiang, Jon C. Aster, John Paul Dumas, Mark C. Pierce, Darren Roblyer
Published 2020-10-01

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

by Felix Oppel, Ting Tao, Hui Shi, Kenneth N Ross, Mark W Zimmerman, Shuning He, Guangxiang Tong, Jon C Aster, A Thomas Look
Published 2019-04-01

IGH rearrangement in myeloid neoplasms

by Amy W. Xiao, Yuyan Jia, Linda B. Baughn, Kathryn E. Pearce, Beth A. Pitel, Jon C. Aster, Paola Dal Cin, Sheng Xiao
Published 2020-06-01

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

by Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
Published 2020-08-01

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

by Jon C Aster, Nick Bodnar, Lanwei Xu, Fredrick Karnell, John M Milholland, Ivan Maillard, Gavin Histen, Yunsun Nam, Stephen C Blacklow, Warren S Pear
Published 2011-01-01

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.

by Wendy R Gordon, Didem Vardar-Ulu, Sarah L'Heureux, Todd Ashworth, Michael J Malecki, Cheryll Sanchez-Irizarry, Debbie G McArthur, Gavin Histen, Jennifer L Mitchell, Jon C Aster, Stephen C Blacklow
Published 2009-08-01

Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies

by Mara M. Epstein, Bernard Rosner, Elizabeth C. Breen, Julie L. Batista, Edward L. Giovannucci, Larry Magpantay, Jon C. Aster, Scott J. Rodig, Kimberly A. Bertrand, Francine Laden, Otoniel Martínez-Maza, Brenda M. Birmann
Published 2018-10-01

IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

by Li Pan, Madeleine E Lemieux, Tom Thomas, Julia M Rogers, Colin H Lipper, Winston Lee, Carl Johnson, Lynette M Sholl, Andrew P South, Jarrod A Marto, Guillaume O Adelmant, Stephen C Blacklow, Jon C Aster
Published 2020-09-01

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

by Vijayashree Mysore, Xavier Cullere, Joseph Mears, Florencia Rosetti, Koshu Okubo, Pei X. Liew, Fan Zhang, Iris Madera-Salcedo, Frank Rosenbauer, Richard M. Stone, Jon C. Aster, Ulrich H. von Andrian, Andrew H. Lichtman, Soumya Raychaudhuri, Tanya N. Mayadas
Published 2021-08-01

AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

by Renata Ferrarotto, Vasudha Mishra, Elad Herz, Adar Yaacov, Oz Solomon, Rami Rauch, Adi Mondshine, Maria Motin, Tal Leibovich-Rivkin, Matti Davis, Joel Kaye, Christopher R. Weber, Le Shen, Alexander T. Pearson, Ari J. Rosenberg, Xiangying Chen, Alka Singh, Jon C. Aster, Nishant Agrawal, Evgeny Izumchenko
Published 2022-08-01

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

by Michelle I Lin, Emily N Price, Sonja Boatman, Elliott J Hagedorn, Eirini Trompouki, Sruthi Satishchandran, Charles W Carspecken, Audrey Uong, Anthony DiBiase, Song Yang, Matthew C Canver, Ann Dahlberg, Zhigang Lu, Cheng Cheng Zhang, Stuart H Orkin, Irwin D Bernstein, Jon C Aster, Richard M White, Leonard I Zon
Published 2015-02-01

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas

by Russell J.H. Ryan, Jelena Petrovic, Dylan M. Rausch, Yeqiao Zhou, Caleb A. Lareau, Michael J. Kluk, Amanda L. Christie, Winston Y. Lee, Daniel R. Tarjan, Bingqian Guo, Laura K.H. Donohue, Shawn M. Gillespie, Valentina Nardi, Ephraim P. Hochberg, Stephen C. Blacklow, David M. Weinstock, Robert B. Faryabi, Bradley E. Bernstein, Jon C. Aster, Warren S. Pear
Published 2017-10-01

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

by Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko, Jing Zhang Zhao, Frederic Baleydier, Sarah L'Heureux, Hongfang Wang, Wendy R Gordon, Elizabeth Thoryk, Marie Blanke Andrawes, Kittichoat Tiyanont, Kimberly Stegmaier, Giovanni Roti, Kenneth N Ross, Laura L Franlin, Hui Wang, Fubao Wang, Michael Chastain, Andrew J Bett, Laurent P Audoly, Jon C Aster, Stephen C Blacklow, Hans E Huber
Published 2010-02-01

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry.

by Michael J Kluk, Todd Ashworth, Hongfang Wang, Birgit Knoechel, Emily F Mason, Elizabeth A Morgan, David Dorfman, Geraldine Pinkus, Oliver Weigert, Jason L Hornick, Lucian R Chirieac, Michelle Hirsch, David J Oh, Andrew P South, Irene M Leigh, Celine Pourreyron, Andrew J Cassidy, Daniel J Deangelo, David M Weinstock, Ian E Krop, Deborah Dillon, Jane E Brock, Alexander J F Lazar, Myron Peto, Raymond J Cho, Alexander Stoeck, Brian B Haines, Sriram Sathayanrayanan, Scott Rodig, Jon C Aster
Published 2013-01-01

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models

by Samuel Y. Ng, Noriaki Yoshida, Amanda L. Christie, Mahmoud Ghandi, Neekesh V. Dharia, Joshua Dempster, Mark Murakami, Kay Shigemori, Sara N. Morrow, Alexandria Van Scoyk, Nicolas A. Cordero, Kristen E. Stevenson, Maneka Puligandla, Brian Haas, Christopher Lo, Robin Meyers, Galen Gao, Andrew Cherniack, Abner Louissaint, Valentina Nardi, Aaron R. Thorner, Henry Long, Xintao Qiu, Elizabeth A. Morgan, David M. Dorfman, Danilo Fiore, Julie Jang, Alan L. Epstein, Ahmet Dogan, Yanming Zhang, Steven M. Horwitz, Eric D. Jacobsen, Solimar Santiago, Jian-Guo Ren, Vincent Guerlavais, D. Allen Annis, Manuel Aivado, Mansoor N. Saleh, Amitkumar Mehta, Aviad Tsherniak, David Root, Francisca Vazquez, William C. Hahn, Giorgio Inghirami, Jon C. Aster, David M. Weinstock, Raphael Koch
Published 2018-05-01

Qualifying Antibodies for Image-Based Immune Profiling and Multiplexed Tissue Imaging

by Lin, Jia-Ren, Rashid, Rumana, Maliga, Zoltan, Izar, Benjamin, Santagata, Sandro, Du, Ziming, Wang, Shu, Aster, Jon, Songer, Peter
Published 2019