Structural modeling of JAK1 mutations in T-cell acute lymphoblastic leukemia reveals a second contact site between pseudokinase and kinase domains

by Kirsten Canté-Barrett, Joost C.M. Uitdehaag, Jules P.P. Meijerink
Published 2016-05-01

The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia

by Rui D. Mendes, Kirsten Canté-Barrett, Rob Pieters, Jules P.P. Meijerink
Published 2016-09-01

Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements

by Irene Homminga, Maartje J. Vuerhard, Anton W. Langerak, Jessica Buijs-Gladdines, Rob Pieters, Jules P.P. Meijerink
Published 2012-02-01

Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic l...

by Nicole S.D. Larmonie, Willem A. Dik, Jules P.P. Meijerink, Irene Homminga, Jacques J.M. van Dongen, Anton W. Langerak
Published 2013-08-01

Recurrent NR3C1 Aberrations at First Diagnosis Relate to Steroid Resistance in Pediatric T-Cell Acute Lymphoblastic Leukemia Patients

by Jordy C. G. van der Zwet, Willem Smits, Jessica G. C. A. M. Buijs-Gladdines, Rob Pieters, Jules P. P. Meijerink
Published 2021-01-01

A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer

by Kirsten Canté-Barrett, Laurent Holtzer, Henk van Ooijen, Rico Hagelaar, Valentina Cordo’, Wim Verhaegh, Anja van de Stolpe, Jules P. P. Meijerink
Published 2020-10-01

Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells.

by Elnaz Farahbakhshian, Monique M Verstegen, Trudi P Visser, Sima Kheradmandkia, Dirk Geerts, Shazia Arshad, Noveen Riaz, Frank Grosveld, Niek P van Til, Jules P P Meijerink
Published 2014-01-01

Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.

by Sarah J Stein, Ethan A Mack, Kelly S Rome, Kostandin V Pajcini, Takuya Ohtani, Lanwei Xu, Yunlei Li, Jules P P Meijerink, Robert B Faryabi, Warren S Pear
Published 2016-01-01

T‐cell lymphoblastic lymphoma in constitutional mismatch repair deficiency (CMMRD): Exploring treatment opportunities

by Emma Kroeze, Dilys D. Weijers, Michelle M. Kleisman, Uri Ilan, Reno S. Bladergroen, Rico Hagelaar, Jules P. P. Meijerink, Marjolijn C. J. Jongmans, Jan L. C. Loeffen, Roland P. Kuiper
Published 2024-05-01

High Prevalence of Constitutional Mismatch Repair Deficiency in a Pediatric T-cell Lymphoblastic Lymphoma Cohort

by Emma Kroeze, Dilys D. Weijers, Melanie M. Hagleitner, Hester A. de Groot-Kruseman, Marjolijn C. J. Jongmans, Roland P. Kuiper, Rob Pieters, Jules P. P. Meijerink, Jan L. C. Loeffen
Published 2022-01-01

Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia

by Diana Schotte, Ellen A.M. Lange-Turenhout, Dominique J.P.M. Stumpel, Ronald W. Stam, Jessica G.C.A.M. Buijs-Gladdines, Jules P.P. Meijerink, Rob Pieters, Monique L. Den Boer
Published 2010-10-01

The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

by Machteld M Tiemessen, Miranda R M Baert, Tom Schonewille, Martijn H Brugman, Farbod Famili, Daniela C F Salvatori, Jules P P Meijerink, Ugur Ozbek, Hans Clevers, Jacques J M van Dongen, Frank J T Staal
Published 2012-01-01

Influence of bisphosphonates or recombinant human parathyroid hormone on <i>in vitro</i> sensitivity of acute lymphoblastic leukemia cells to chemotherapy

by Demi T.C. de Winter, Jenneke E. van Atteveld, Jessica G.C.A.M. Buijs-Gladiness, Rob Pieters, Sebastian J.C.M.M. Neggers, Jules P.P. Meijerink, Marry M. van den Heuvel-Eibrink
Published 2022-10-01

MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus

by Kirsten Canté-Barrett, Mariska T. Meijer, Valentina Cordo’, Rico Hagelaar, Wentao Yang, Jiyang Yu, Willem K. Smits, Marloes E. Nulle, Joris P. Jansen, Rob Pieters, Jun J. Yang, Jody J. Haigh, Steven Goossens, Jules P.P. Meijerink
Published 2022-07-01

STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of <i>BCL2</i> and <i>BCLXL</i> following glucocorticoid treatment

by Jordy C.G. van der Zwet, Valentina Cordo’, Jessica G.C.A.M. Buijs-Gladdines, Rico Hagelaar, Willem K. Smits, Eric Vroegindeweij, Laura T.M. Graus, Vera Poort, Marloes Nulle, Rob Pieters, Jules P.P. Meijerink
Published 2022-06-01

Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways

by Miriam Butler, Miriam Butler, Britt M.T. Vervoort, Dorette S. van Ingen Schenau, Lieneke Jongeneel, Jordy C.G. van der Zwet, René Marke, Jules P.P. Meijerink, Blanca Scheijen, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen
Published 2022-09-01

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

by Linda Zuurbier, Emanuel F. Petricoin, Maartje J. Vuerhard, Valerie Calvert, Clarissa Kooi, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Edwin Sonneveld, Anjo J.P. Veerman, Willem A. Kamps, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink
Published 2012-09-01

Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies

by Valentina Cordo’, Mariska T. Meijer, Rico Hagelaar, Richard R. de Goeij-de Haas, Vera M. Poort, Alex A. Henneman, Sander R. Piersma, Thang V. Pham, Koichi Oshima, Adolfo A. Ferrando, Guido J. R. Zaman, Connie R. Jimenez, Jules P. P. Meijerink
Published 2022-02-01

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors

by Linda Zuurbier, Alejandro Gutierrez, Charles G. Mullighan, Kirsten Canté-Barrett, A. Olivier Gevaert, Johan de Rooi, Yunlei Li, Willem K. Smits, Jessica G.C.A.M. Buijs-Gladdines, Edwin Sonneveld, A. Thomas Look, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink
Published 2014-01-01

The role of the mineralocorticoid receptor in steroidinduced cytotoxicity in pediatric acute lymphoblastic leukemia

by Annelienke M. van Hulst, Jordy C.G. van der Zwet, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Marta Fiocco, Rob Pieters, Frank N. van Leeuwen, Marry M. van den Heuvel-Eibrink, Erica L.T. van den Akker, Jules P.P. Meijerink
Published 2024-01-01