SCA8 CAG/CTG expansions, a tale of two TOXICities: a unique or common case?

by Karine Merienne, Yvon Trottier
Published 2009-08-01

Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion

by Anna Niewiadomska-Cimicka, Anna Niewiadomska-Cimicka, Anna Niewiadomska-Cimicka, Anna Niewiadomska-Cimicka, Antoine Hache, Antoine Hache, Antoine Hache, Antoine Hache, Yvon Trottier, Yvon Trottier, Yvon Trottier, Yvon Trottier
Published 2020-06-01

Transcriptional activation of REST by Sp1 in Huntington's disease models.

by Myriam Ravache, Chantal Weber, Karine Mérienne, Yvon Trottier
Published 2010-12-01

Longitudinal MRI and 1H-MRS study of SCA7 mouse forebrain reveals progressive multiregional atrophy and early brain metabolite changes indicating early neuronal and glial dysfuncti...

by Jean-Baptiste Pérot, Anna Niewiadomska-Cimicka, Emmanuel Brouillet, Yvon Trottier, Julien Flament
Published 2024-01-01

Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model

by Piotr Piasecki, Kalina Wiatr, Milosz Ruszkowski, Łukasz Marczak, Yvon Trottier, Maciej Figiel
Published 2023-03-01

Longitudinal MRI and 1H-MRS study of SCA7 mouse forebrain reveals progressive multiregional atrophy and early brain metabolite changes indicating early neuronal and glial dysfuncti...

by Jean-Baptiste Pérot, Anna Niewiadomska-Cimicka, Emmanuel Brouillet, Yvon Trottier, Julien Flament
Published 2024-01-01

Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations

by Magdalena Surdyka, Ewelina Jesion, Anna Niewiadomska-Cimicka, Yvon Trottier, Żaneta Kalinowska-Pośka, Maciej Figiel
Published 2022-09-01

Transcription elongation and tissue-specific somatic CAG instability.

by Agathi-Vasiliki Goula, Agnieszka Stys, Jackson P K Chan, Yvon Trottier, Richard Festenstein, Karine Merienne
Published 2012-01-01

Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy

by Karine Merienne, James Friedman, Masayuki Akimoto, Gretta Abou-Sleymane, Chantal Weber, Anand Swaroop, Yvon Trottier
Published 2007-03-01

Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.

by Agathi-Vassiliki Goula, Brian R Berquist, David M Wilson, Vanessa C Wheeler, Yvon Trottier, Karine Merienne
Published 2009-12-01

A novel function of Huntingtin in the cilium and retinal ciliopathy in Huntington's disease mice

by Alice Karam, Lars Tebbe, Chantal Weber, Nadia Messaddeq, Laurette Morlé, Pascal Kessler, Uwe Wolfrum, Yvon Trottier
Published 2015-08-01

Heterogeneous Intracellular Localization and Expression of Ataxin-3

by Yvon Trottier, Géraldine Cancel, Isabelle An-Gourfinkel, Yves Lutz, Chantal Weber, Alexis Brice, Etienne Hirsch, Jean-Louis Mandel
Published 1998-11-01

Polyglutamine toxicity induces rod photoreceptor division, morphological transformation or death in Spinocerebellar ataxia 7 mouse retina

by Marina G. Yefimova, Nadia Messaddeq, Alice Karam, Carine Jacquard, Chantal Weber, Laurent Jonet, Uwe Wolfrum, Jean-Claude Jeanny, Yvon Trottier
Published 2010-10-01

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

by Dominique Helmlinger, Sara Hardy, Gretta Abou-Sleymane, Adrien Eberlin, Aaron B Bowman, Anne Gansmüller, Serge Picaud, Huda Y Zoghbi, Yvon Trottier, Làszlò Tora, Didier Devys
Published 2006-03-01

Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy

by Anna Niewiadomska-Cimicka, Antoine Hache, Stéphanie Le Gras, Céline Keime, Tao Ye, Aurelie Eisenmann, Imen Harichane, Michel J. Roux, Nadia Messaddeq, Emmanuelle Clérin, Thierry Léveillard, Yvon Trottier
Published 2022-12-01

AAV-Mediated CAG-Targeting Selectively Reduces Polyglutamine-Expanded Protein and Attenuates Disease Phenotypes in a Spinocerebellar Ataxia Mouse Model

by Anna Niewiadomska-Cimicka, Lorraine Fievet, Magdalena Surdyka, Ewelina Jesion, Céline Keime, Elisabeth Singer, Aurélie Eisenmann, Zaneta Kalinowska-Poska, Hoa Huu Phuc Nguyen, Agnieszka Fiszer, Maciej Figiel, Yvon Trottier
Published 2024-04-01

PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases

by Junko Takahashi, Hiroto Fujigasaki, Kiyoshi Iwabuchi, Amalia C Bruni, Toshiki Uchihara, Khalid H El Hachimi, Giovanni Stevanin, Alexandra Dürr, Anne-Sophie Lebre, Yvon Trottier, Hugues de Thé, Junichi Tanaka, Jean-Jacques Hauw, Charles Duyckaerts, Alexis Brice
Published 2003-08-01