New Synthesized Activating Transcription Factor 3 Inducer SW20.1 Suppresses Resistin-Induced Metabolic Syndrome

by Tu T. Tran, Wei-Jan Huang, Heng Lin, Hsi-Hsien Chen
Published 2023-05-01

Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and β-amyloid Aggregation

by Liang-Chieh Chen, Liang-Chieh Chen, Hui-Ju Tseng, Chang-Yi Liu, Yun-Yi Huang, Cheng-Chung Yen, Jing-Ru Weng, Yeh-Lin Lu, Yeh-Lin Lu, Wen-Chi Hou, Tony E. Lin, I-Horng Pan, Kuo-Kuei Huang, Wei-Jan Huang, Wei-Jan Huang, Wei-Jan Huang, Wei-Jan Huang, Kai-Cheng Hsu
Published 2018-07-01

Dibenzofuran, 4-Chromanone, Acetophenone, and Dithiecine Derivatives: Cytotoxic Constituents from <i>Eupatorium fortunei</i>

by Chun-Hao Chang, Semon Wu, Kai-Cheng Hsu, Wei-Jan Huang, Jih-Jung Chen
Published 2021-07-01

Pan-Inhibition of Protein Disulfide Isomerase Caused Cell Death through Disrupting Cellular Proteostasis in Pancreatic Ductal Adenocarcinoma Cells

by Ching-Sheng Hung, Kun-Lin Lee, Wei-Jan Huang, Fang-He Su, Yu-Chih Liang
Published 2023-11-01

Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative

by Liang-Chieh Chen, Kai-Cheng Hsu, Lih-Chu Chiou, Hui-Ju Tseng, Wei-Jan Huang
Published 2017-11-01

Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats.

by Tzu-Yu Lin, Wei-Jan Huang, Chia-Chan Wu, Cheng-Wei Lu, Su-Jane Wang
Published 2014-01-01

Chemical Constituents Analysis and Antidiabetic Activity Validation of Four Fern Species from Taiwan

by Chen-Yu Chen, Fu-Yu Chiu, Yenshou Lin, Wei-Jan Huang, Po-Shiuan Hsieh, Feng-Lin Hsu
Published 2015-01-01

Low-Luminance Blue Light-Enhanced Phototoxicity in A2E-Laden RPE Cell Cultures and Rats

by Cheng-Hui Lin, Man-Ru Wu, Wei-Jan Huang, Diana Shu-Lian Chow, George Hsiao, Yu-Wen Cheng
Published 2019-04-01

HADC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-Induced Mouse Model of Neuroinflammation and Microglial Activation

by Fan-Li Lin, Jing-Lun Yen, Yu-Cheng Kuo, Jaw-Jou Kang, Yu-Wen Cheng, Wei-Jan Huang, George Hsiao
Published 2019-01-01

N-Hydroxycinnamide Derivatives of Osthole Ameliorate Hyperglycemia through Activation of AMPK and p38 MAPK

by Wei-Hwa Lee, Hsueh-Hsia Wu, Wei-Jan Huang, Yi-Ning Li, Ren-Jye Lin, Shyr-Yi Lin, Yu-Chih Liang
Published 2015-03-01

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

by Wohn-Jenn Leu, Jung-Chun Chu, Jui-Ling Hsu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Wei-Jan Huang, Jih-Hwa Guh
Published 2020-12-01

Evaluation of Antioxidant and Free Radical Scavenging Capacities of Polyphenolics from Pods of &lt;em&gt;Caesalpinia pulcherrima&lt;/em&gt;

by Mei-Hsiang Lin, Mei-Hsien Lee, Lih-Chi Chen, Wen-Chi Hou, Hsiao-Jen Lu, Tzu-Hua Wu, Feng-Lin Hsu, Wei-Jan Huang
Published 2012-05-01

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

by Kai-Cheng Hsu, Chang-Yi Liu, Tony Eight Lin, Jui-Hua Hsieh, Tzu-Ying Sung, Hui-Ju Tseng, Jinn-Moon Yang, Wei-Jan Huang
Published 2017-06-01

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo.

by Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Yi-An Chen, Yi-Shiou Chiou, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang
Published 2013-01-01

Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment

by Tony Eight Lin, Chia-Ron Yang, Ching-Hsuan Chou, Jui-Yi Hsu, Min-Wu Chao, Tzu-Ying Sung, Jui-Hua Hsieh, Wei-Jan Huang, Kai-Cheng Hsu
Published 2022-02-01

The study of a novel CDK8 inhibitor E966-0530–45418 that inhibits prostate cancer metastasis in vitro and in vivo

by Tai-Yuan Ho, Ting-Yi Sung, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu, Jui-Yi Hsu, Tony Eight Lin, Chia-Ming Hsu, Chia-Ron Yang
Published 2023-06-01

Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors

by Jui-Yi Hsu, Kai-Cheng Hsu, Ching Sun, Ching-Hsuan Chou, Tony Eight Lin, Tzu-Ying Sung, Hui-Ju Tseng, Shih-Chung Yen, Chia-Ron Yang, Wei-Jan Huang
Published 2023-03-01

A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer

by Hui-Wen Chiu, Ya-Ling Yeh, Sheng-Yow Ho, Yuan-Hua Wu, Bour-Jr Wang, Wei-Jan Huang, Yuan-Soon Ho, Ying-Jan Wang, Li-Ching Chen, Shih-Hsin Tu
Published 2019-11-01

A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress

by Liang-Huan Wu, Yu-Wen Cheng, Fan-Li Lin, Kai-Cheng Hsu, Mong-Heng Wang, Jing-Lun Yen, Tsung-Jen Wang, Tony Eight Lin, Yi-Chien Liu, Wei-Jan Huang, George Hsiao
Published 2024-05-01

1,2,3,4,6-Penta-O-galloyl-<span style="font-variant: small-caps">d</span>-glucose Interrupts the Early Adipocyte Lifecycle and Attenuates Adiposity and Hepatic Steatosis in Mice wi...

by Ashish Rao Sathyanarayana, Chung-Kuang Lu, Chih-Chuang Liaw, Chia-Chuan Chang, Hsin-Ying Han, Brian D. Green, Wei-Jan Huang, Cheng Huang, Wen-Di He, Lin-Chien Lee, Hui-Kang Liu
Published 2022-04-01