Ugonin J Acts as a SARS-CoV-2 3C-like Protease Inhibitor and Exhibits Anti-inflammatory Properties

by Wei-Chung Chiou, Hsu-Feng Lu, Hsu-Feng Lu, Nung-Yu Hsu, Tein-Yao Chang, Yuan-Fan Chin, Ping-Cheng Liu, Jir-Mehng Lo, Yeh B Wu, Jinn-Moon Yang, Jinn-Moon Yang, Jinn-Moon Yang, Jinn-Moon Yang, Jinn-Moon Yang, Cheng Huang
Published 2021-08-01

A novel graph convolutional neural network for predicting interaction sites on protein kinase inhibitors in phosphorylation

by Feiqi Wang, Yun-Ti Chen, Jinn-Moon Yang, Tatsuya Akutsu
Published 2022-01-01

Densest subgraph-based methods for protein-protein interaction hot spot prediction

by Ruiming Li, Jung-Yu Lee, Jinn-Moon Yang, Tatsuya Akutsu
Published 2022-10-01

Reconstructing genome-wide protein-protein interaction networks using multiple strategies with homologous mapping.

by Yu-Shu Lo, Sing-Han Huang, Yong-Chun Luo, Chun-Yu Lin, Jinn-Moon Yang
Published 2015-01-01

Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways.

by Kai-Cheng Hsu, Wen-Chi Cheng, Yen-Fu Chen, Wen-Ching Wang, Jinn-Moon Yang
Published 2013-01-01

Combinatorial computational approaches to identify tetracycline derivatives as flavivirus inhibitors.

by Jinn-Moon Yang, Yan-Fu Chen, Yu-Yin Tu, Kuei-Rong Yen, Yun-Liang Yang
Published 2007-01-01

Pharmacophore anchor models of flaviviral NS3 proteases lead to drug repurposing for DENV infection

by Nikhil Pathak, Mei-Ling Lai, Wen-Yu Chen, Betty-Wu Hsieh, Guann-Yi Yu, Jinn-Moon Yang
Published 2017-12-01

CoMI: consensus mutual information for tissue-specific gene signatures

by Sing-Han Huang, Yu-Shu Lo, Yong-Chun Luo, Yi-Hsuan Chuang, Jung-Yu Lee, Jinn-Moon Yang
Published 2022-04-01

Inhibition of IRAK1 Is an Effective Therapy for Autoimmune Hypophysitis in Mice

by Hsiao-Chen Huang, Yun-Ti Chen, Han-Huei Lin, Zhi-Qin Li, Jinn-Moon Yang, Shey-Cherng Tzou
Published 2022-11-01

Target Identification Using Homopharma and Network-Based Methods for Predicting Compounds Against Dengue Virus-Infected Cells

by Kowit Hengphasatporn, Kitiporn Plaimas, Apichat Suratanee, Peemapat Wongsriphisant, Jinn-Moon Yang, Yasuteru Shigeta, Warinthorn Chavasiri, Siwaporn Boonyasuppayakorn, Thanyada Rungrotmongkol
Published 2020-04-01

Transcriptomic analysis of World Trade Center particulate Matter-induced pulmonary inflammation and drug treatments

by Yun-Ti Chen, Jinhui Li, Jen-Ning Chang, Yong-Chun Luo, Wuyue Yu, Lung-Chi Chen, Jinn-Moon Yang
Published 2023-07-01

Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model

by Li-Chi Huang, Ching-Ling Lin, Jia-Zheng Qiu, Chun-Yu Lin, Kai-Wen Hsu, Ka-Wai Tam, Ka-Wai Tam, Ka-Wai Tam, Jung-Yu Lee, Jinn-Moon Yang, Jinn-Moon Yang, Chia-Hwa Lee, Chia-Hwa Lee, Chia-Hwa Lee
Published 2017-11-01

Exploring kinase family inhibitors and their moiety preferences using deep SHapley additive exPlanations

by You-Wei Fan, Wan-Hsin Liu, Yun-Ti Chen, Yen-Chao Hsu, Nikhil Pathak, Yu-Wei Huang, Jinn-Moon Yang
Published 2022-06-01

Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors

by Wei-Chung Chiou, Meng-Shiuan Hsu, Yun-Ti Chen, Jinn-Moon Yang, Yeou-Guang Tsay, Hsiu-Chen Huang, Cheng Huang
Published 2021-01-01

Identification of pan-kinase-family inhibitors using graph convolutional networks to reveal family-sensitive pre-moieties

by Xiang-Yu Lin, Yu-Wei Huang, You-Wei Fan, Yun-Ti Chen, Nikhil Pathak, Yen-Chao Hsu, Jinn-Moon Yang
Published 2022-06-01

Core site-moiety maps reveal inhibitors and binding mechanisms of orthologous proteins by screening compound libraries.

by Kai-Cheng Hsu, Wen-Chi Cheng, Yen-Fu Chen, Hung-Jung Wang, Ling-Ting Li, Wen-Ching Wang, Jinn-Moon Yang
Published 2012-01-01

Convolutional neural network for human cancer types prediction by integrating protein interaction networks and omics data

by Yi-Hsuan Chuang, Sing-Han Huang, Tzu-Mao Hung, Xiang-Yu Lin, Jung-Yu Lee, Wen-Sen Lai, Jinn-Moon Yang
Published 2021-10-01

Discovery of moiety preference by Shapley value in protein kinase family using random forest models

by Yu-Wei Huang, Yen-Chao Hsu, Yi-Hsuan Chuang, Yun-Ti Chen, Xiang-Yu Lin, You-Wei Fan, Nikhil Pathak, Jinn-Moon Yang
Published 2022-04-01

Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.

by Wen-Chi Cheng, Yen-Fu Chen, Hung-Jung Wang, Kai-Cheng Hsu, Shuang-Chih Lin, Tzu-Jung Chen, Jinn-Moon Yang, Wen-Ching Wang
Published 2012-01-01

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

by Kai-Cheng Hsu, Chang-Yi Liu, Tony Eight Lin, Jui-Hua Hsieh, Tzu-Ying Sung, Hui-Ju Tseng, Jinn-Moon Yang, Wei-Jan Huang
Published 2017-06-01