Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity

by Congcong Zhang, Congcong Zhang, Congcong Zhang, Pranav Oberoi, Sarah Oelsner, Anja Waldmann, Aline Lindner, Torsten Tonn, Torsten Tonn, Torsten Tonn, Torsten Tonn, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels
Published 2017-05-01

Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy

by Dapeng Zhou, Lan Xu, Wei Huang, Torsten Tonn
Published 2018-05-01

Anti-SARS-CoV-2 Revaccination Success in Kidney Transplant Recipients With No Initial Humoral Response Is Linked to Primary Vaccine Type

by Julian Stumpf, Julian Stumpf, Jörg Schwöbel, Claudia Karger, Holger Schirutschke, René Mauer, Anna Klimova, Torsten Tonn, Torsten Tonn, Christian Hugo, Christian Hugo
Published 2022-07-01

Editorial: Translating NK cell scientific research to clinical product manufacturing

by Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Volker Huppert, Torsten Tonn, Wing Leung
Published 2023-08-01

CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy

by Michael C. Burger, Michael C. Burger, Michael C. Burger, Michael C. Burger, Congcong Zhang, Congcong Zhang, Congcong Zhang, Patrick N. Harter, Patrick N. Harter, Patrick N. Harter, Patrick N. Harter, Annette Romanski, Florian Strassheimer, Florian Strassheimer, Christian Senft, Christian Senft, Christian Senft, Torsten Tonn, Torsten Tonn, Torsten Tonn, Torsten Tonn, Joachim P. Steinbach, Joachim P. Steinbach, Joachim P. Steinbach, Joachim P. Steinbach, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels
Published 2019-11-01

Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer

by Nivedha Murali Shankar, Nivedha Murali Shankar, Nivedha Murali Shankar, Nivedha Murali Shankar, Paola Ortiz-Montero, Paola Ortiz-Montero, Anastasia Kurzyukova, Anastasia Kurzyukova, Wiebke Rackwitz, Wiebke Rackwitz, Stephan R. Künzel, Stephan R. Künzel, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Torsten Tonn, Torsten Tonn, Torsten Tonn, Franziska Knopf, Franziska Knopf, Jiri Eitler, Jiri Eitler
Published 2023-10-01

Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting

by Torsten Tonn, Winfried Wels, Jiri Eitler, Natalie Wotschel, Nicole Miller, Laurent Boissel, Hans G Klingemann
Published 2021-01-01

NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme

by Shafiq Murad, Susanne Michen, Alexander Becker, Monika Füssel, Gabriele Schackert, Torsten Tonn, Frank Momburg, Achim Temme
Published 2022-05-01

Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

by Renata Nacasaki Silvestre, Jiri Eitler, Jiri Eitler, Julia Teixeira Cottas de Azevedo, Mariane Cariati Tirapelle, Daianne Maciely Carvalho Fantacini, Lucas Eduardo Botelho de Souza, Kamilla Swiech, Dimas Tadeu Covas, Rodrigo T. Calado, Paola Ortiz Montero, Paola Ortiz Montero, Kelen Cristina Ribeiro Malmegrim, Kelen Cristina Ribeiro Malmegrim, Marxa L. Figueiredo, Torsten Tonn, Torsten Tonn, Torsten Tonn, Virginia Picanço-Castro
Published 2023-09-01

Stability and neutralising capacity of SARS-CoV-2-specific antibodies in convalescent plasma

by Torsten Tonn, Victor M Corman, Matthias Johnsen, Anja Richter, Roman N Rodionov, Christian Drosten, Stefan R Bornstein
Published 2020-06-01

MMF/MPA Is the Main Mediator of a Delayed Humoral Response With Reduced Antibody Decline in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination

by Julian Stumpf, Julian Stumpf, Torsten Siepmann, Jörg Schwöbel, Grit Glombig, Alexander Paliege, Anne Steglich, Florian Gembardt, Friederike Kessel, Hannah Kröger, Patrick Arndt, Jan Sradnick, Kerstin Frank, Anna Klimova, René Mauer, Torsten Tonn, Torsten Tonn, Christian Hugo, Christian Hugo
Published 2022-07-01

442-Q CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation

by Torsten Tonn, Winfried Wels, Hans Klingemann, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Paola Ortiz Montero, Wiebke Rackwitz, Venugopal Gudipati, Johannes Huppa
Published 2023-11-01

Palbociclib impairs the proliferative capacity of activated T cells while retaining their cytotoxic efficacy

by Claudia Arndt, Claudia Arndt, Antje Tunger, Antje Tunger, Rebekka Wehner, Rebekka Wehner, Rebekka Wehner, Rebecca Rothe, Rebecca Rothe, Eleni Kourtellari, Stephanie Luttosch, Katharina Hannemann, Stefanie Koristka, Liliana R. Loureiro, Anja Feldmann, Torsten Tonn, Torsten Tonn, Torsten Tonn, Theresa Link, Theresa Link, Theresa Link, Jan Dominik Kuhlmann, Jan Dominik Kuhlmann, Jan Dominik Kuhlmann, Pauline Wimberger, Pauline Wimberger, Pauline Wimberger, Michael Philipp Bachmann, Michael Philipp Bachmann, Michael Philipp Bachmann, Michael Philipp Bachmann, Marc Schmitz, Marc Schmitz, Marc Schmitz
Published 2023-02-01

Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

by Susann Rahmig, Romy Kronstein-Wiedemann, Juliane Fohgrub, Nicole Kronstein, Aleksandra Nevmerzhitskaya, Martin Bornhäuser, Max Gassmann, Alexander Platz, Rainer Ordemann, Torsten Tonn, Claudia Waskow
Published 2016-10-01

EV-3, an endogenous human erythropoietin isoform with distinct functional relevance

by Christel Bonnas, Liane Wüstefeld, Daniela Winkler, Romy Kronstein-Wiedemann, Ekrem Dere, Katja Specht, Melanie Boxberg, Torsten Tonn, Hannelore Ehrenreich, Herbert Stadler, Inge Sillaber
Published 2017-06-01

Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A.

by Stefanie D Roth, Jörg Schüttrumpf, Peter Milanov, Daniela Abriss, Christopher Ungerer, Patricia Quade-Lyssy, Jeremy C Simpson, Rainer Pepperkok, Erhard Seifried, Torsten Tonn
Published 2012-01-01

Quality of life and metabolic outcomes after total pancreatectomy and simultaneous islet autotransplantation

by Stefan Ludwig, Marius Distler, Undine Schubert, Janine Schmid, Henriette Thies, Thilo Welsch, Sebastian Hempel, Torsten Tonn, Jürgen Weitz, Stefan R. Bornstein, Barbara Ludwig
Published 2022-03-01

Serum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer

by David Digomann, Max Heiduk, Charlotte Reiche, Jessica Glück, Christoph Kahlert, Peter Mirtschink, Anna Klimova, Florian Bösch, Torsten Tonn, Jochen Gaedcke, Michael Ghadimi, Jürgen Weitz, Lena Seifert, Adrian M. Seifert
Published 2023-10-01

Expression of Glypican 3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes

by Mohammad Rahbari, Mathieu Pecqueux, Daniela Aust, Holger Stephan, Oliver Tiebel, Antonios Chatzigeorgiou, Torsten Tonn, Franziska Baenke, Venkatesh Rao, Nicole Ziegler, Helena Greif, Kuailu Lin, Juergen Weitz, Nuh Nabi Rahbari, Christoph Kahlert
Published 2019-05-01

OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines

by Miriam N. Jacobs, Jan M. Bult, Kevin Cavanagh, Christophe Chesne, Nathalie Delrue, Jianan Fu, Emma Grange, Ingrid Langezaal, Dominika Misztela, Jenny Murray, Martin Paparella, Gilly Stoddart, Torsten Tonn, Carol Treasure, Masaaki Tsukano, Rosemary Versteegen
Published 2023-02-01