Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting

by Torsten Tonn, Winfried Wels, Jiri Eitler, Natalie Wotschel, Nicole Miller, Laurent Boissel, Hans G Klingemann
Published 2021-01-01

CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages

by Gulce Itir Percin, Jiri Eitler, Andrea Kranz, Jun Fu, Jeffrey W. Pollard, Ronald Naumann, Claudia Waskow
Published 2018-12-01

442-Q CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation

by Torsten Tonn, Winfried Wels, Hans Klingemann, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Paola Ortiz Montero, Wiebke Rackwitz, Venugopal Gudipati, Johannes Huppa
Published 2023-11-01

Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer

by Nivedha Murali Shankar, Nivedha Murali Shankar, Nivedha Murali Shankar, Nivedha Murali Shankar, Paola Ortiz-Montero, Paola Ortiz-Montero, Anastasia Kurzyukova, Anastasia Kurzyukova, Wiebke Rackwitz, Wiebke Rackwitz, Stephan R. Künzel, Stephan R. Künzel, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Torsten Tonn, Torsten Tonn, Torsten Tonn, Franziska Knopf, Franziska Knopf, Jiri Eitler, Jiri Eitler
Published 2023-10-01

Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

by Renata Nacasaki Silvestre, Jiri Eitler, Jiri Eitler, Julia Teixeira Cottas de Azevedo, Mariane Cariati Tirapelle, Daianne Maciely Carvalho Fantacini, Lucas Eduardo Botelho de Souza, Kamilla Swiech, Dimas Tadeu Covas, Rodrigo T. Calado, Paola Ortiz Montero, Paola Ortiz Montero, Kelen Cristina Ribeiro Malmegrim, Kelen Cristina Ribeiro Malmegrim, Marxa L. Figueiredo, Torsten Tonn, Torsten Tonn, Torsten Tonn, Virginia Picanço-Castro
Published 2023-09-01

CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation

by Torsten Tonn, Hans Klingemann, Winfried S Wels, Jiri Eitler, Natalie Wotschel, Laurent Boissel, Michael Bachmann, Wiebke Rackwitz, Venugopal Gudipati, Nivedha Murali Shankar, Anastasia Sidorenkova, Johannes B Huppa, Paola Ortiz-Montero, Corinna Opitz, Stephan R Künzel, Susanne Michen, Achim Temme, Liliana Rodrigues Loureiro, Anja Feldmann
Published 2024-02-01