Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2

by Lihong Huang, Terrence Tsz-Tai Yuen, Zuodong Ye, Shuyan Liu, Guoliang Zhang, Hin Chu, Jianbo Yue
Published 2021-04-01

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs

by Xi Zhang, Hin Chu, Kenn Ka-Heng Chik, Lei Wen, Huiping Shuai, Dong Yang, Yixin Wang, Yuxin Hou, Terrence Tsz-Tai Yuen, Jian-Piao Cai, Shuofeng Yuan, Feifei Yin, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Published 2022-12-01

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

by Zheng Zhu, Hin Chu, Lei Wen, Shuofeng Yuan, Kenn Ka-Heng Chik, Terrence Tsz-Tai Yuen, Cyril Chik-Yan Yip, Dong Wang, Jie Zhou, Feifei Yin, Dong-Yan Jin, Kin-Hang Kok, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Published 2019-01-01

Vaccine-induced protection against SARS-CoV-2 requires IFN-γ-driven cellular immune response

by Xiaolei Wang, Terrence Tsz-Tai Yuen, Ying Dou, Jingchu Hu, Renhao Li, Zheng Zeng, Xuansheng Lin, Huarui Gong, Celia Hoi-Ching Chan, Chaemin Yoon, Huiping Shuai, Deborah Tip-Yin Ho, Ivan Fan-Ngai Hung, Bao-Zhong Zhang, Hin Chu, Jian-Dong Huang
Published 2023-06-01

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2

by Bingjie Hu, Jasper Fuk-Woo Chan, Huan Liu, Yuanchen Liu, Yue Chai, Jialu Shi, Huiping Shuai, Yuxin Hou, Xiner Huang, Terrence Tsz-Tai Yuen, Chaemin Yoon, Tianrenzheng Zhu, Jinjin Zhang, Wenjun Li, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Bao-Zhong Zhang, Kwok-Yung Yuen, Hin Chu
Published 2022-12-01

STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells

by Dong Yang, Hin Chu, Gang Lu, Huiping Shuai, Yixin Wang, Yuxin Hou, Xi Zhang, Xiner Huang, Bingjie Hu, Yue Chai, Terrence Tsz-Tai Yuen, Xiaoyu Zhao, Andrew Chak-Yiu Lee, Ziwei Ye, Cun Li, Kenn Ka-Heng Chik, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Jasper Fuk-Woo Chan
Published 2021-01-01

Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

by Wei Qiao, Hui En Lau, Huizhi Xie, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Hin Chu, Shuofeng Yuan, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Jian-Piao Cai, Cuiting Luo, Kwok-Yung Yuen, Kenneth Man-Chee Cheung, Jasper Fuk-Woo Chan, Kelvin Wai-Kwok Yeung
Published 2022-05-01

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

by Wei Qiao, Hui En Lau, Huizhi Xie, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Hin Chu, Shuofeng Yuan, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Jian-Piao Cai, Cuiting Luo, Kwok-Yong Yuen, Kenneth Man-Chee Cheung, Jasper Fuk-Woo Chan, Kelvin Wai-Kwok Yeung
Published 2022-05-01

Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice

by Bao-Zhong Zhang, Huiping Shuai, Hua-Rui Gong, Jing-Chu Hu, Bingpeng Yan, Terrence Tsz-Tai Yuen, Ye-Fan Hu, Chaemin Yoon, Xiao-Lei Wang, Yuxin Hou, Xuansheng Lin, Xiner Huang, Renhao Li, Yee Man Au-Yeung, Wenjun Li, Bingjie Hu, Yue Chai, Ming Yue, Jian-Piao Cai, Guang Sheng Ling, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Jian-Dong Huang, Hin Chu
Published 2022-06-01

The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5Research in context

by Huiping Shuai, Jasper Fuk-Woo Chan, Bingjie Hu, Yue Chai, Chaemin Yoon, Huan Liu, Yuanchen Liu, Jialu Shi, Tianrenzheng Zhu, Jing-Chu Hu, Ye-fan Hu, Yuxin Hou, Xiner Huang, Terrence Tsz-Tai Yuen, Yang Wang, Jinjin Zhang, Yao Xia, Lin-Lei Chen, Jian-Piao Cai, Anna Jinxia Zhang, Shuofeng Yuan, Jie Zhou, Bao-Zhong Zhang, Jian-Dong Huang, Kwok-Yung Yuen, Kelvin Kai-Wang To, Hin Chu
Published 2023-09-01

Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA.2/5 subvariants in the upper and lower respiratory tractResearch in context

by Bingjie Hu, Jasper Fuk-Woo Chan, Yuanchen Liu, Huan Liu, Yan-Xia Chen, Huiping Shuai, Ye-Fan Hu, Madeline Hartnoll, Li Chen, Yao Xia, Jing-Chu Hu, Terrence Tsz-Tai Yuen, Chaemin Yoon, Yuxin Hou, Xiner Huang, Yue Chai, Tianrenzheng Zhu, Jialu Shi, Yang Wang, Yixin He, Jian-Piao Cai, Jie Zhou, Shuofeng Yuan, Jinxia Zhang, Jian-Dong Huang, Kwok-Yung Yuen, Kelvin Kai-Wang To, Bao-Zhong Zhang, Hin Chu
Published 2024-01-01

SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of...

by Hin Chu, Jasper Fuk-Woo Chan, Yixin Wang, Terrence Tsz-Tai Yuen, Yue Chai, Huiping Shuai, Dong Yang, Bingjie Hu, Xiner Huang, Xi Zhang, Yuxin Hou, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Kelvin Kai-Wang To, Ivan Fan-Ngai Hung, Tan To Cheung, Ada Tsui-Lin Ng, Ivy Hau-Yee Chan, Ian Yu-Hong Wong, Simon Ying-Kit Law, Dominic Chi-Chung Foo, Wai-Keung Leung, Kwok-Yung Yuen
Published 2021-01-01

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

by Hin Chu, Bingjie Hu, Xiner Huang, Yue Chai, Dongyan Zhou, Yixin Wang, Huiping Shuai, Dong Yang, Yuxin Hou, Xi Zhang, Terrence Tsz-Tai Yuen, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Kelvin Kai-Wang To, Ivy Hau-Yee Chan, Ko-Yung Sit, Dominic Chi-Chung Foo, Ian Yu-Hong Wong, Ada Tsui-Lin Ng, Tan To Cheung, Simon Ying-Kit Law, Wing-Kuk Au, Melinda A. Brindley, Zhiwei Chen, Kin-Hang Kok, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Published 2021-01-01

Emerging SARS-CoV-2 variants expand species tropism to murines

by Huiping Shuai, Jasper Fuk-Woo Chan, Terrence Tsz-Tai Yuen, Chaemin Yoon, Jing-Chu Hu, Lei Wen, Bingjie Hu, Dong Yang, Yixin Wang, Yuxin Hou, Xiner Huang, Yue Chai, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Lu Lu, Rui-Qi Zhang, Wan-Mui Chan, Jonathan Daniel Ip, Allen Wing-Ho Chu, Ye-Fan Hu, Jian-Piao Cai, Kwok-Hung Chan, Jie Zhou, Siddharth Sridhar, Bao-Zhong Zhang, Shuofeng Yuan, Anna Jinxia Zhang, Jian-Dong Huang, Kelvin Kai-Wang To, Kwok-Yung Yuen, Hin Chu
Published 2021-11-01

Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory stud...

by Hin Chu, PhD, Jasper Fuk-Woo Chan, MD, Terrence Tsz-Tai Yuen, BA, Huiping Shuai, PhD, Shuofeng Yuan, PhD, Yixin Wang, MPhil, Bingjie Hu, MPhil, Cyril Chik-Yan Yip, PhD, Jessica Oi-Ling Tsang, BSc, Xiner Huang, BSc, Yue Chai, MPhil, Dong Yang, MPhil, Yuxin Hou, MPhil, Kenn Ka-Heng Chik, MMedSc, Xi Zhang, BSc, Agnes Yim-Fong Fung, BSc, Hoi-Wah Tsoi, MPhil, Jian-Piao Cai, BSc, Wan-Mui Chan, PhD, Jonathan Daniel Ip, MSc, Allen Wing-Ho Chu, MSc, Jie Zhou, PhD, David Christopher Lung, FRCPath, Kin-Hang Kok, PhD, Kelvin Kai-Wang To, MD, Owen Tak-Yin Tsang, FRCP, Kwok-Hung Chan, PhD, Kwok-Yung Yuen, ProfMD
Published 2020-05-01