Manipulating regulatory T cells: is it the key to unlocking effective immunotherapy for pancreatic ductal adenocarcinoma?

by Henry Smith, Edward Arbe-Barnes, Enas Abu Shah, Shivan Sivakumar, Shivan Sivakumar
Published 2024-05-01

Circulating Cell-Free Tumour DNA for Early Detection of Pancreatic Cancer

by Jedrzej J. Jaworski, Robert D. Morgan, Shivan Sivakumar
Published 2020-12-01

Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis.

by Shivan Sivakumar, Ines de Santiago, Leon Chlon, Florian Markowetz
Published 2017-01-01

HER2 Expression in Gastric Cancer: Rare, Heterogeneous and of No Prognostic Value – Conclusions from 924 Cases of Two Independent Series

by Heike Grabsch, Shivan Sivakumar, Sally Gray, Helmut E. Gabbert, Wolfram Müller
Published 2010-01-01

The COVID-19 Pandemic Is Associated with Reduced Survival after Pancreatic Ductal Adenocarcinoma Diagnosis: A Single-Centre Retrospective Analysis

by Oliver Madge, Alexandra Brodey, Jordan Bowen, George Nicholson, Shivan Sivakumar, Matthew J. Bottomley
Published 2022-05-01

Advances in Immunotherapeutics in Pancreatic Ductal Adenocarcinoma

by Tarak Chouari, Francesca Soraya La Costa, Nabeel Merali, Maria-Danae Jessel, Shivan Sivakumar, Nicola Annels, Adam E. Frampton
Published 2023-08-01

Nerve Fibers in the Tumor Microenvironment as a Novel Biomarker for Oncological Outcome in Patients Undergoing Surgery for Perihilar Cholangiocarcinoma

by Jan Bednarsch, Jakob Kather, Xiuxiang Tan, Shivan Sivakumar, Claudio Cacchi, Georg Wiltberger, Zoltan Czigany, Florian Ulmer, Ulf Peter Neumann, Lara Rosaline Heij
Published 2021-05-01

Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (Ther...

by Laura Spiers, Michael Gray, Paul Lyon, Shivan Sivakumar, Noor Bekkali, Shaun Scott, Linda Collins, Robert Carlisle, Feng Wu, Mark Middleton, Constantin Coussios
Published 2023-09-01

ToxNav germline genetic testing and PROMinet digital mobile application toxicity monitoring: Results of a prospective single‐center clinical utility study—PRECISE study

by Lennard Y. W. Lee, Thomas Starkey, Shivan Sivakumar, Susan Fotheringham, Guy Mozolowski, Vanessa Shearwood, Claire Palles, Philip Camilleri, David Church, Rachel Kerr, David Kerr
Published 2019-10-01

Pseudotime dynamics of T cells in pancreatic ductal adenocarcinoma inform distinct functional states within the regulatory and cytotoxic T cells

by Ashwin Jainarayanan, Nithishwer Mouroug-Anand, Edward H. Arbe-Barnes, Adam J. Bush, Rachael Bashford-Rogers, Adam Frampton, Lara Heij, Mark Middleton, Michael L. Dustin, Enas Abu-Shah, Shivan Sivakumar
Published 2023-04-01

Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade Therapy

by Lara Heij, Jan Bednarsch, Xiuxiang Tan, Mika Rosin, Simone Appinger, Konrad Reichel, Dana Pecina, Michail Doukas, Ronald M. van Dam, Juan Garcia Vallejo, Florian Ulmer, Sven Lang, Tom Luedde, Flavio G. Rocha, Shivan Sivakumar, Ulf Peter Neumann
Published 2023-03-01

Evaluation of pre-analytical factors affecting plasma DNA analysis

by Havell Markus, Tania Contente-Cuomo, Maria Farooq, Winnie S. Liang, Mitesh J. Borad, Shivan Sivakumar, Simon Gollins, Nhan L. Tran, Harshil D. Dhruv, Michael E. Berens, Alan Bryce, Aleksandar Sekulic, Antoni Ribas, Jeffrey M. Trent, Patricia M. LoRusso, Muhammed Murtaza
Published 2018-05-01

Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic Cancer

by Shivan Sivakumar, Enas Abu-Shah, David J. Ahern, Edward H. Arbe-Barnes, Ashwin K. Jainarayanan, Nagina Mangal, Srikanth Reddy, Aniko Rendek, Alistair Easton, Elke Kurz, Michael Silva, Zahir Soonawalla, Lara R. Heij, Rachael Bashford-Rogers, Mark R. Middleton, Michael L. Dustin
Published 2021-04-01

The Presence of Small Nerve Fibers in the Tumor Microenvironment as Predictive Biomarker of Oncological Outcome Following Partial Hepatectomy for Intrahepatic Cholangiocarcinoma

by Jan Bednarsch, Xiuxiang Tan, Zoltan Czigany, Dong Liu, Sven Arke Lang, Shivan Sivakumar, Jakob Nikolas Kather, Simone Appinger, Mika Rosin, Shiva Boroojerdi, Edgar Dahl, Nadine Therese Gaisa, Marcel den Dulk, Mariëlle Coolsen, Tom Florian Ulmer, Ulf Peter Neumann, Lara Rosaline Heij
Published 2021-07-01

Bile Microbiome Signatures Associated with Pancreatic Ductal Adenocarcinoma Compared to Benign Disease: A UK Pilot Study

by Nabeel Merali, Tarak Chouari, Julien Terroire, Maria-Danae Jessel, Daniel S. K. Liu, James-Halle Smith, Tyler Wooldridge, Tony Dhillon, José I. Jiménez, Jonathan Krell, Keith J. Roberts, Timothy A. Rockall, Eirini Velliou, Shivan Sivakumar, Elisa Giovannetti, Ayse Demirkan, Nicola E. Annels, Adam E. Frampton
Published 2023-11-01

Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer

by Lara R. Heij, Xiuxiang Tan, Jakob N. Kather, Jan M. Niehues, Shivan Sivakumar, Nicole Heussen, Gregory van der Kroft, Steven W. M. Olde Damink, Sven Lang, Merel R. Aberle, Tom Luedde, Nadine T. Gaisa, Jan Bednarsch, Drolaiz H. W. Liu, Jack P. M. Cleutjens, Dominik P. Modest, Ulf P. Neumann, Georg J. Wiltberger
Published 2021-01-01

A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease

by Mireia Mato Prado, Jisce R. Puik, Leandro Castellano, Elena López-Jiménez, Daniel S. K. Liu, Laura L. Meijer, Tessa Y. S. Le Large, Eleanor Rees, Niccola Funel, Shivan Sivakumar, Stephen P. Pereira, Geert Kazemier, Babs M. Zonderhuis, Joris I. Erdmann, Rutger-Jan Swijnenburg, Andrea Frilling, Long R. Jiao, Justin Stebbing, Elisa Giovannetti, Jonathan Krell, Adam E. Frampton
Published 2023-12-01

PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

by Xiuxiang Tan, Jan Bednarsch, Mika Rosin, Simone Appinger, Dong Liu, Georg Wiltberger, Juan Garcia Vallejo, Sven Arke Lang, Zoltan Czigany, Shiva Boroojerdi, Nadine T. Gaisa, Peter Boor, Roman David Bülow, Judith De Vos-Geelen, Liselot Valkenburg-van Iersel, Marian C. Clahsen-van Groningen, Evelien J. M. de Jong, Bas Groot Koerkamp, Michail Doukas, Flavio G. Rocha, Tom Luedde, Uwe Klinge, Shivan Sivakumar, Ulf Peter Neumann, Lara Rosaline Heij
Published 2022-04-01