The non-clonality of drug resistance in Beijing-genotype isolates of <it>Mycobacterium tuberculosis </it>from the Western Cape of South Africa

by Van Helden Paul D, Gey van Pittius Nicolaas C, Warren Robin M, Streicher Elizabeth M, Victor Thomas C, Chen Xiaohua, Dobos Karen M, Feng Yicheng, Ioerger Thomas R, Sacchettini James C
Published 2010-11-01

Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.

by Daniel-Wayman, Shelby, Abate, Getahun, Barber, Daniel L, Bermudez, Luiz E, Coler, Rhea N, Cynamon, Michael H, Daley, Charles L, Davidson, Rebecca M, Dick, Thomas, Floto, R Andres, Henkle, Emily, Holland, Steven M, Jackson, Mary, Lee, Richard E, Nuermberger, Eric L, Olivier, Kenneth N, Ordway, Diane J, Prevots, D Rebecca, Sacchettini, James C, Salfinger, Max, Sassetti, Christopher M, Sizemore, Christine F, Winthrop, Kevin L, Zelazny, Adrian M
Published 2019

Impact of immunopathology on the antituberculous activity of pyrazinamide.

by Blanc, Landry, Sarathy, Jansy Passiflora, Alvarez Cabrera, Nadine, O'Brien, Paul, Dias-Freedman, Isabela, Mina, Marizel, Sacchettini, James, Savic, Radojka M, Gengenbacher, Martin, Podell, Brendan K, Prideaux, Brendan, Ioerger, Thomas, Dick, Thomas, Dartois, Véronique
Published 2018

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

by Yadon, Adam N., Maharaj, Kashmeel, Adamson, John H., Lai, Yi-Pin, Sacchettini, James C., Ioerger, Thomas R., Rubin, Eric J., Pym, Alexander S.
Published 2017

Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis

by Zhang, Yanjia Jason, Ioerger, Thomas R., Huttenhower, Curtis, Long, Jarukit E., Sassetti, Christopher M., Sacchettini, James C., Rubin, Eric Joseph
Published 2013

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

by Stanley, Sarah, Kawate, Tomohiko, Iwase, Noriaki, Shimizu, Motohisa, Clatworthy, Anne, Kazyanskaya, Edward, Sacchettini, James, Ioerger, Thomas, Siddiqi, Noman, Minami, Shoko, Aquadro, John, Grant, Sarah Schmidt, Rubin, Eric, Hung, Deborah
Published 2019

Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists

by Katti, Sachin S., Krieger, Inna, V, Ann, Jihyae, Lee, Jeewoo, Sacchettini, James C., Igumenova, Tatyana I.
Published 2022

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

by Gomez, James E, Kaufmann-Malaga, Benjamin B, Wivagg, Carl N, Kim, Peter B, Silvis, Melanie R, Renedo, Nikolai, Ioerger, Thomas R, Ahmad, Rushdy, Livny, Jonathan, Fishbein, Skye, Sacchettini, James C, Carr, Steven A, Hung, Deborah T
Published 2017

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis

by Martinot, Amanda J., Farrow, Mary, Bai, Lu, Layre, Emilie, Cheng, Tan-Yun, Tsai, Jennifer H., Iqbal, Jahangir, Annand, John W., Sullivan, Zuri A., Hussain, M. Mahmood, Sacchettini, James, Moody, D. Branch, Seeliger, Jessica C., Rubin, Eric J.
Published 2016

Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility

by Kieser, Karen, Baranowski, Catherine, Chao, Michael, Long, Jarukit, Sassetti, Christopher, Waldor, Matthew, Sacchettini, James, Ioerger, Thomas, Rubin, Eric
Published 2019

High-Throughput Sequencing Enhanced Phage Display Identifies Peptides That Bind Mycobacteria

by Ngubane, Nqobile A. C., Gresh, Lionel, Ioerger, Thomas R., Sacchettini, James C., Zhang, Yanjia J., Rubin, Eric J., Pym, Alexander, Khati, Makobetsa
Published 2014

MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

by Rosa, Valentina La, Poce, Giovanna, Canseco, Julio Ortiz, Buroni, Silvia, Pasca, Maria Rosalia, Biava, Mariangela, Raju, Ravikiran M., Porretta, Giulio Cesare, Alfonso, Salvatore, Battilocchio, Claudio, Javid, Babak, Sorrentino, Flavia, Ioerger, Thomas R., Sacchettini, James C., Manetti, Fabrizio, Botta, Maurizio, Logu, Alessandro De, Rubin, Eric J., Rossi, Edda De
Published 2019

A vitamin B12 transporter in Mycobacterium tuberculosis

by Gopinath, Krishnamoorthy, Venclovas, Česlovas, Ioerger, Thomas R., Sacchettini, James C., McKinney, John D., Mizrahi, Valerie, Warner, Digby F.
Published 2013

Sterilization of granulomas is common in both active and latent tuberculosis despite extensive within-host variability in bacterial killing

by Lin, Philana Ling, Ford, Christopher B., Coleman, M. Teresa, Myers, Amy J., Gawande, Richa, Ioerger, Thomas, Sacchettini, James, Fortune, Sarah M., Flynn, JoAnne L.
Published 2014

Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

by Ioerger, Thomas R., O’Malley, Theresa, Liao, Reiling, Guinn, Kristine M., Hickey, Mark J., Mohaideen, Nilofar, Murphy, Kenan C., Boshoff, Helena I. M., Mizrahi, Valerie, Rubin, Eric J., Sassetti, Christopher M., Barry, Clifton E., Sherman, David R., Parish, Tanya, Sacchettini, James C.
Published 2014

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan...

by Lopez Quezada, Landys, Smith, Robert, Lupoli, Tania J., Edoo, Zainab, Li, Xiaojun, Gold, Ben, Roberts, Julia, Ling, Yan, Park, Sae Woong, Nguyen, Quyen, Schoenen, Frank J., Li, Kelin, Hugonnet, Jean-Emmanuel, Arthur, Michel, Sacchettini, James C., Nathan, Carl, Aubé, Jeffrey
Published 2020

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

by Carey, Allison F., Rock, Jeremy M., Krieger, Inna V., Chase, Michael R., Fernandez-Suarez, Marta, Gagneux, Sebastien, Sacchettini, James C., Ioerger, Thomas R., Fortune, Sarah M.
Published 2018