Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data.

by Ida Kappel Buhl, Sarah Gerster, Mauro Delorenzi, Thomas Jensen, Peter Buhl Jensen, Fred Bosman, Sabine Tejpar, Arnaud Roth, Nils Brunner, Anker Hansen, Steen Knudsen
Published 2016-01-01

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

by Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi, Abhishek D. Garg
Published 2020-01-01

miR-345 in metastatic colorectal cancer: a non-invasive biomarker for clinical outcome in non-KRAS mutant patients treated with 3rd line cetuximab and irinotecan.

by Jakob V Schou, Simona Rossi, Benny V Jensen, Dorte L Nielsen, Per Pfeiffer, Estrid Høgdall, Mette Yilmaz, Sabine Tejpar, Mauro Delorenzi, Mogens Kruhøffer, Julia S Johansen
Published 2014-01-01

Neutrophils suppress tumor‐infiltrating T cells in colon cancer via matrix metalloproteinase‐mediated activation of TGFβ

by Markus Germann, Nadine Zangger, Marc‐Olivier Sauvain, Christine Sempoux, Amber D Bowler, Pratyaksha Wirapati, Lana E Kandalaft, Mauro Delorenzi, Sabine Tejpar, George Coukos, Freddy Radtke
Published 2020-01-01

Clinical Validation of Targeted Next Generation Sequencing for Colon and Lung Cancers.

by Nicky D'Haene, Marie Le Mercier, Nancy De Nève, Oriane Blanchard, Mélanie Delaunoy, Hakim El Housni, Barbara Dessars, Pierre Heimann, Myriam Remmelink, Pieter Demetter, Sabine Tejpar, Isabelle Salmon
Published 2015-01-01

Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids.

by Els Robanus-Maandag, Cathy Bosch, Saeid Amini-Nik, Jeroen Knijnenburg, Karoly Szuhai, Pascale Cervera, Raymond Poon, Diana Eccles, Paolo Radice, Marco Giovannini, Benjamin A Alman, Sabine Tejpar, Peter Devilee, Riccardo Fodde
Published 2011-01-01

Phase II open-label study to assess efficacy and safety of lenalidomide in combination with cetuximab in KRAS-mutant metastatic colorectal cancer.

by Salvatore Siena, Eric Van Cutsem, Mingyu Li, Ulf Jungnelius, Alfredo Romano, Robert Beck, Katia Bencardino, Maria Elena Elez, Hans Prenen, Mireia Sanchis, Andrea Sartore-Bianchi, Sabine Tejpar, Anita Gandhi, Tao Shi, Josep Tabernero
Published 2013-01-01

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

by Peter J. Belmont, Eva Budinska, Ping Jiang, Mark J. Sinnamon, Erin Coffee, Jatin Roper, Tao Xie, Paul A. Rejto, Sahra Derkits, Owen J. Sansom, Mauro Delorenzi, Sabine Tejpar, Kenneth E. Hung, Eric S. Martin
Published 2014-06-01

Multiregional transcriptomics identifies congruent consensus subtypes with prognostic value beyond tumor heterogeneity of colorectal cancer

by Jonas Langerud, Ina A. Eilertsen, Seyed H. Moosavi, Solveig M. K. Klokkerud, Henrik M. Reims, Ingeborg F. Backe, Merete Hektoen, Ole H. Sjo, Marine Jeanmougin, Sabine Tejpar, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Published 2024-05-01

Molecular portraits of colorectal cancer morphological regions

by Eva Budinská, Martina Hrivňáková, Tina Catela Ivkovic, Marie Madrzyk, Rudolf Nenutil, Beatrix Bencsiková, Dagmar Al Tukmachi, Michaela Ručková, Lenka Zdražilová Dubská, Ondřej Slabý, Josef Feit, Mihnea-Paul Dragomir, Petra Borilova Linhartova, Sabine Tejpar, Vlad Popovici
Published 2023-11-01

Establishing a Unified COVID-19 “Immunome”: Integrating Coronavirus Pathogenesis and Host Immunopathology

by Els Wauters, Karin Thevissen, Carine Wouters, Carine Wouters, Francesca Maria Bosisio, Frederik De Smet, Jan Gunst, Stephanie Humblet-Baron, Diether Lambrechts, Adrian Liston, Patrick Matthys, Johan Neyts, Paul Proost, Birgit Weynand, Joost Wauters, Sabine Tejpar, Abhishek D. Garg
Published 2020-07-01

894 Conserved immune inhibitory receptor-signaling in macrophages limits antitumour chemo-immunotherapy

by Sabine Tejpar, Abhishek D Garg, Louis Boon, Massimiliano Mazzone, Jenny Sprooten, Isaure Vanmeerbeek, Stefan Naulaerts, Raquel Salvador, Jannes Govaerts, Rosa Trotta, Samantha Pretto, Shikang Zhao, Sarah Trusso Cafarello, Joren Verelst, Maarten Jacquemyn, Martyna Pociupany, Susan M Schlenner, Dirk Daelemans
Published 2023-11-01

Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines

by Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D. Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui
Published 2024-03-01

A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations.

by Tao Xie, Giovanni D' Ario, John R Lamb, Eric Martin, Kai Wang, Sabine Tejpar, Mauro Delorenzi, Fred T Bosman, Arnaud D Roth, Pu Yan, Stephanie Bougel, Antonio Fabio Di Narzo, Vlad Popovici, Eva Budinská, Mao Mao, Scott L Weinrich, Paul A Rejto, J Graeme Hodgson
Published 2012-01-01

Cell type signatures in cell-free DNA fragmentation profiles reveal disease biology

by Kate E. Stanley, Tatjana Jatsenko, Stefania Tuveri, Dhanya Sudhakaran, Lore Lannoo, Kristel Van Calsteren, Marie de Borre, Ilse Van Parijs, Leen Van Coillie, Kris Van Den Bogaert, Rodrigo De Almeida Toledo, Liesbeth Lenaerts, Sabine Tejpar, Kevin Punie, Laura Y. Rengifo, Peter Vandenberghe, Bernard Thienpont, Joris Robert Vermeesch
Published 2024-03-01

Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer

by Antonia Carla Testa, Sabine Tejpar, Ignace Vergote, Valentina Chiappa, An Coosemans, Thaïs Baert, Chiara Landolfo, Wouter Froyman, Dirk Timmerman, Tom Bourne, Abhishek D Garg, Patrizia Agostinis, Louis Boon, Daniela Fischerova, Caroline Van Holsbeke, Jenny Sprooten, Ann Vankerckhoven, Isaure Vanmeerbeek, Daniel M Borras, Yani Berckmans, Roxanne Wouters, Raquel S Laureano, Dominique Schols
Published 2021-11-01

Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer

by Daniel Morales Borràs, Sara Verbandt, Markus Ausserhofer, Gregor Sturm, Jinyeong Lim, Gil Arasa Verge, Isaure Vanmeerbeek, Raquel S. Laureano, Jannes Govaerts, Jenny Sprooten, Yourae Hong, Rebecca Wall, Gert De Hertogh, Xavier Sagaert, Gabriele Bislenghi, André D’Hoore, Albert Wolthuis, Francesca Finotello, Woong-Yang Park, Stefan Naulaerts, Sabine Tejpar, Abhishek D. Garg
Published 2023-11-01

Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal AdenocarcinomasSummary

by Lochlan Fennell, Troy Dumenil, Leesa Wockner, Gunter Hartel, Katia Nones, Catherine Bond, Jennifer Borowsky, Cheng Liu, Diane McKeone, Lisa Bowdler, Grant Montgomery, Kerenaftali Klein, Isabell Hoffmann, Ann-Marie Patch, Stephen Kazakoff, John Pearson, Nicola Waddell, Pratyaksha Wirapati, Paul Lochhead, Yu Imamura, Shuji Ogino, Renfu Shao, Sabine Tejpar, Barbara Leggett, Vicki Whitehall
Published 2019-01-01

Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer

by Karen Gambaro, Maud Marques, Suzan McNamara, Mathilde Couetoux du Tertre, Zuanel Diaz, Cyrla Hoffert, Archana Srivastava, Steven Hébert, Benoit Samson, Bernard Lespérance, Yoo‐Joung Ko, Richard Dalfen, Eve St‐Hilaire, Lucas Sideris, Felix Couture, Ronald Burkes, Mohammed Harb, Errol Camlioglu, Adrian Gologan, Vincent Pelsser, André Constantin, Celia M.T. Greenwood, Sabine Tejpar, Petr Kavan, Claudia L. Kleinman, Gerald Batist
Published 2021-04-01

Real-time diagnostic accuracy of blue light imaging, linked color imaging and white-light endoscopy for colorectal polyp characterization

by Britt B.S.L. Houwen, Jasper L.A. Vleugels, Maria Pellisé, Liseth Rivero-Sánchez, Francesc Balaguer, Raf Bisschops, Sabine Tejpar, Alessandro Repici, D. Ramsoekh, M. A.J.M Jacobs, Ramon-Michel Schreuder, Michal F. Kamiński, Maria Rupińska, Pradeep Bhandari, M. G.H. van Oijen, L. Koens, Barbara A.J. Bastiaansen, K. M.A.J. Tytgat, Paul Fockens, Evelien Dekker, Yark Hazewinkel
Published 2022-01-01