Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

by Sami Gabbouj, Simo Ryhänen, Mikael Marttinen, Rebekka Wittrahm, Mari Takalo, Susanna Kemppainen, Henna Martiskainen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen, Teemu Natunen
Published 2019-06-01

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

by Rebekka Wittrahm, Mari Takalo, Mikael Marttinen, Teemu Kuulasmaa, Petra Mäkinen, Susanna Kemppainen, Henna Martiskainen, Tuomas Rauramaa, Ian Pike, Ville Leinonen, Teemu Natunen, Annakaisa Haapasalo, Mikko Hiltunen
Published 2021-04-01

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

by Mikael Marttinen, Mari Takalo, Teemu Natunen, Rebekka Wittrahm, Sami Gabbouj, Susanna Kemppainen, Ville Leinonen, Ville Leinonen, Ville Leinonen, Ville Leinonen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen
Published 2018-12-01

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

by Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, Christian Haass
Published 2020-09-01

BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci

by Hannah Rostalski, Tomi Hietanen, Stina Leskelä, Andrea Behánová, Ali Abdollahzadeh, Rebekka Wittrahm, Petra Mäkinen, Nadine Huber, Dorit Hoffmann, Eino Solje, Eino Solje, Anne M. Remes, Anne M. Remes, Teemu Natunen, Mari Takalo, Jussi Tohka, Mikko Hiltunen, Annakaisa Haapasalo
Published 2020-10-01

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

by Rebekka Wittrahm, Mari Takalo, Teemu Kuulasmaa, Petra M. Mäkinen, Petri Mäkinen, Saša Končarević, Vadim Fartzdinov, Stefan Selzer, Tarja Kokkola, Leila Antikainen, Henna Martiskainen, Susanna Kemppainen, Mikael Marttinen, Heli Jeskanen, Hannah Rostalski, Eija Rahunen, Miia Kivipelto, Tiia Ngandu, Teemu Natunen, Jean-Charles Lambert, Rudolph E. Tanzi, Doo Yeon Kim, Tuomas Rauramaa, Sanna-Kaisa Herukka, Hilkka Soininen, Markku Laakso, Ian Pike, Ville Leinonen, Annakaisa Haapasalo, Mikko Hiltunen
Published 2023-06-01