Focal cerebral ischemia in rats alters APP processing and expression of Aβ peptide degrading enzymes in the thalamus

by Mikko Hiltunen, Petra Mäkinen, Sirpa Peräniemi, Juhani Sivenius, Thomas van Groen, Hilkka Soininen, Jukka Jolkkonen
Published 2009-07-01

Isoflurane affects brain functional connectivity in rats 1 month after exposure

by Petteri Stenroos, Tiina Pirttimäki, Jaakko Paasonen, Ekaterina Paasonen, Raimo A Salo, Hennariikka Koivisto, Teemu Natunen, Petra Mäkinen, Teemu Kuulasmaa, Mikko Hiltunen, Heikki Tanila, Olli Gröhn
Published 2021-07-01

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

by Rebekka Wittrahm, Mari Takalo, Mikael Marttinen, Teemu Kuulasmaa, Petra Mäkinen, Susanna Kemppainen, Henna Martiskainen, Tuomas Rauramaa, Ian Pike, Ville Leinonen, Teemu Natunen, Annakaisa Haapasalo, Mikko Hiltunen
Published 2021-04-01

Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.

by Tiina Laiterä, Timo Sarajärvi, Annakaisa Haapasalo, Lakshman Puli, Tarja Kauppinen, Petra Mäkinen, Tuomas Rauramaa, Heikki Tanila, Juha E Jääskeläinen, Irina Alafuzoff, Hilkka Soininen, Ville Leinonen, Mikko Hiltunen
Published 2014-01-01

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

by Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, Christian Haass
Published 2020-09-01

Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates

by Susanna Kemppainen, Nadine Huber, Roosa-Maria Willman, Ana Zamora, Petra Mäkinen, Henna Martiskainen, Mari Takalo, Annakaisa Haapasalo, Tomás Sobrino, Manuel Antonio González Gómez, Yolanda Piñeiro, José Rivas, Uwe Himmelreich, Mikko Hiltunen
Published 2023-05-01

Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease.

by Teemu Natunen, Henna Martiskainen, Timo Sarajärvi, Seppo Helisalmi, Juha-Pekka Pursiheimo, Jayashree Viswanathan, Marjo Laitinen, Petra Mäkinen, Tarja Kauppinen, Tuomas Rauramaa, Ville Leinonen, Irina Alafuzoff, Annakaisa Haapasalo, Hilkka Soininen, Mikko Hiltunen
Published 2013-01-01

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ

by Mikael Marttinen, Catarina B. Ferreira, Kaisa M. A. Paldanius, Mari Takalo, Teemu Natunen, Petra Mäkinen, Luukas Leppänen, Ville Leinonen, Kenji Tanigaki, Gina Kang, Noboru Hiroi, Hilkka Soininen, Kirsi Rilla, Annakaisa Haapasalo, Mikko Hiltunen
Published 2020-11-01

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology

by Mikael Marttinen, Jussi Paananen, Antonio Neme, Vikram Mitra, Mari Takalo, Teemu Natunen, Kaisa M.A. Paldanius, Petra Mäkinen, Michael Bremang, Mitja I. Kurki, Tuomas Rauramaa, Ville Leinonen, Hilkka Soininen, Annakaisa Haapasalo, Ian Pike, Mikko Hiltunen
Published 2019-04-01

BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci

by Hannah Rostalski, Tomi Hietanen, Stina Leskelä, Andrea Behánová, Ali Abdollahzadeh, Rebekka Wittrahm, Petra Mäkinen, Nadine Huber, Dorit Hoffmann, Eino Solje, Eino Solje, Anne M. Remes, Anne M. Remes, Teemu Natunen, Mari Takalo, Jussi Tohka, Mikko Hiltunen, Annakaisa Haapasalo
Published 2020-10-01

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

by Henna Martiskainen, Kaisa M. A. Paldanius, Teemu Natunen, Mari Takalo, Mikael Marttinen, Stina Leskelä, Nadine Huber, Petra Mäkinen, Enni Bertling, Hiramani Dhungana, Mikko Huuskonen, Paavo Honkakoski, Pirta Hotulainen, Kirsi Rilla, Jari Koistinaho, Hilkka Soininen, Tarja Malm, Annakaisa Haapasalo, Mikko Hiltunen
Published 2017-11-01

Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

by Teemu Natunen, Henna Martiskainen, Mikael Marttinen, Sami Gabbouj, Hennariikka Koivisto, Susanna Kemppainen, Satu Kaipainen, Mari Takalo, Helena Svobodová, Luukas Leppänen, Benjam Kemiläinen, Simo Ryhänen, Teemu Kuulasmaa, Eija Rahunen, Sisko Juutinen, Petra Mäkinen, Pasi Miettinen, Tuomas Rauramaa, Jussi Pihlajamäki, Annakaisa Haapasalo, Ville Leinonen, Heikki Tanila, Mikko Hiltunen
Published 2020-11-01

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models

by Teemu Natunen, Mari Takalo, Susanna Kemppainen, Stina Leskelä, Mikael Marttinen, Kaisa M.A. Kurkinen, Juha-Pekka Pursiheimo, Timo Sarajärvi, Jayashree Viswanathan, Sami Gabbouj, Eino Solje, Eveliina Tahvanainen, Tiina Pirttimäki, Mitja Kurki, Jussi Paananen, Tuomas Rauramaa, Pasi Miettinen, Petra Mäkinen, Ville Leinonen, Hilkka Soininen, Kari Airenne, Rudolph E. Tanzi, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen
Published 2016-01-01

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

by Catarina B. Ferreira, Mikael Marttinen, Joana E. Coelho, Kaisa M.A. Paldanius, Mari Takalo, Petra Mäkinen, Luukas Leppänen, Catarina Miranda-Lourenço, João Fonseca-Gomes, Sara R. Tanqueiro, Sandra H. Vaz, Rita F. Belo, Ana Maria Sebastião, Ville Leinonen, Hilkka Soininen, Ian Pike, Annakaisa Haapasalo, Luísa V. Lopes, Alexandre de Mendonça, Maria José Diógenes, Mikko Hiltunen
Published 2022-02-01