Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

by Patrick E MacDonald, Patrik Rorsman
Published 2006-02-01

Focused Review: Glucagon secretion and signaling in the development of diabetes

by Herbert eGaisano, Patrick E MacDonald, Mladen eVranic
Published 2012-09-01

DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals

by Patrick E. MacDonald, Xiaoqing Dai, Elisa Vergari, Gregory Plummer
Published 2012-05-01

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

by Shara Khan, Mourad Ferdaoussi, Austin Bautista, Valérie Bergeron, Nancy Smith, Vincent Poitout, Patrick E. MacDonald
Published 2019-10-01

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

by Mourad Ferdaoussi, Jianyang Fu, Xiaoqing Dai, Jocelyn E. Manning Fox, Kunimasa Suzuki, Nancy Smith, Gregory Plummer, Patrick E. MacDonald
Published 2017-03-01

Modulation of insulin secretion by RBFOX2-mediated alternative splicing

by Nicole D. Moss, Kristen L. Wells, Alexandra Theis, Yong-Kyung Kim, Aliya F. Spigelman, Xiong Liu, Patrick E. MacDonald, Lori Sussel
Published 2023-11-01

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

by Jelena Kolic, Jocelyn E. Manning Fox, Oleg G. Chepurny, Aliya F. Spigelman, Mourad Ferdaoussi, Frank Schwede, George G. Holz, Patrick E. MacDonald
Published 2016-07-01

Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

by Scott A. Campbell, Dominic P. Golec, Matt Hubert, Janyne Johnson, Nicole Salamon, Amy Barr, Patrick E. MacDonald, Koenraad Philippaert, Peter E. Light
Published 2020-09-01

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

by Jessica R. Gooding, Mette V. Jensen, Xiaoqing Dai, Brett R. Wenner, Danhong Lu, Ramamani Arumugam, Mourad Ferdaoussi, Patrick E. MacDonald, Christopher B. Newgard
Published 2015-10-01

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

by Patrick E MacDonald, Yang Zhang De Marinis, Reshma Ramracheya, Albert Salehi, Xiaosong Ma, Paul R V Johnson, Roger Cox, Lena Eliasson, Patrik Rorsman
Published 2007-06-01

Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

by Mourad Ferdaoussi, Nancy Smith, Haopeng Lin, Austin Bautista, Aliya F. Spigelman, James Lyon, XiaoQing Dai, Jocelyn E. Manning Fox, Patrick E. MacDonald
Published 2020-04-01

Yield, cell composition, and function of islets isolated from different ages of neonatal pigs

by Hossein Arefanian, Hossein Arefanian, Qahir Ramji, Nancy Gupta, Aliya F. Spigelman, Donald Grynoch, Patrick E. MacDonald, Thomas F. Mueller, Lawrence S. Gazda, Ray V. Rajotte, Gina R. Rayat
Published 2022-12-01

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

by Andrew R. Pepper, Rena Pawlick, Antonio Bruni, John Wink, Yasmin Rafiei, Doug O’Gorman, Richard Yan-Do, Boris Gala-Lopez, Tatsuya Kin, Patrick E. MacDonald, A.M. James Shapiro
Published 2017-06-01

Cryopreservation and post-thaw characterization of dissociated human islet cells.

by Leah A Marquez-Curtis, Xiao-Qing Dai, Yan Hang, Jonathan Y Lam, James Lyon, Jocelyn E Manning Fox, Locksley E McGann, Patrick E MacDonald, Seung K Kim, Janet A W Elliott
Published 2022-01-01

Cryopreservation and post-thaw characterization of dissociated human islet cells

by Leah A. Marquez-Curtis, Xiao-Qing Dai, Yan Hang, Jonathan Y. Lam, James Lyon, Jocelyn E. Manning Fox, Locksley E. McGann, Patrick E. MacDonald, Seung K. Kim, Janet A. W. Elliott
Published 2022-01-01

From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science

by Andraž Stožer, Marko Šterk, Marko Šterk, Eva Paradiž Leitgeb, Rene Markovič, Rene Markovič, Maša Skelin Klemen, Cara E. Ellis, Lidija Križančić Bombek, Jurij Dolenšek, Jurij Dolenšek, Patrick E. MacDonald, Marko Gosak, Marko Gosak
Published 2022-06-01

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

by Tamadher A. Alghamdi, Nicole A.J. Krentz, Nancy Smith, Aliya F. Spigelman, Varsha Rajesh, Alokkumar Jha, Mourad Ferdaoussi, Kunimasa Suzuki, Jing Yang, Jocelyn E. Manning Fox, Han Sun, Zijie Sun, Anna L. Gloyn, Patrick E. MacDonald
Published 2022-12-01

A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

by Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F. Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R. Pepper, Leticia P. Roma, Emmanuel Ampofo, Wen-hong Li, Patrick E. MacDonald
Published 2024-01-01

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.

by Martijn van de Bunt, Jocelyn E Manning Fox, Xiaoqing Dai, Amy Barrett, Caleb Grey, Lei Li, Amanda J Bennett, Paul R Johnson, Raymond V Rajotte, Kyle J Gaulton, Emmanouil T Dermitzakis, Patrick E MacDonald, Mark I McCarthy, Anna L Gloyn
Published 2015-12-01

CRISPR-based genome editing in primary human pancreatic islet cells

by Romina J. Bevacqua, Xiaoqing Dai, Jonathan Y. Lam, Xueying Gu, Mollie S. H. Friedlander, Krissie Tellez, Irene Miguel-Escalada, Silvia Bonàs-Guarch, Goutham Atla, Weichen Zhao, Seung Hyun Kim, Antonia A. Dominguez, Lei S. Qi, Jorge Ferrer, Patrick E. MacDonald, Seung K. Kim
Published 2021-04-01