The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases

by Nunilo Cremades, Christopher M. Dobson
Published 2018-01-01

Characterisation of Amyloid Aggregation and Inhibition by Diffusion-Based Single-Molecule Fluorescence Techniques

by David Polanco, Alejandra Carrancho, Pablo Gracia, Nunilo Cremades
Published 2022-11-01

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease

by Pablo Gracia, José D. Camino, Laura Volpicelli-Daley, Nunilo Cremades
Published 2020-10-01

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity

by Jaime Santos, Pablo Gracia, Susanna Navarro, Samuel Peña-Díaz, Jordi Pujols, Nunilo Cremades, Irantzu Pallarès, Salvador Ventura
Published 2021-06-01

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau

by Pablo Gracia, David Polanco, Jorge Tarancón-Díez, Ilenia Serra, Maruan Bracci, Javier Oroz, Douglas V. Laurents, Inés García, Nunilo Cremades
Published 2022-08-01

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

by Roberta Cascella, Serene W. Chen, Alessandra Bigi, José D. Camino, Catherine K. Xu, Christopher M. Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi
Published 2021-03-01

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.

by Francesco A Aprile, Anne Dhulesia, Florian Stengel, Cintia Roodveldt, Justin L P Benesch, Paolo Tortora, Carol V Robinson, Xavier Salvatella, Christopher M Dobson, Nunilo Cremades
Published 2013-01-01

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

by Catherine K. Xu, Marta Castellana-Cruz, Serene W. Chen, Zhen Du, Georg Meisl, Aviad Levin, Benedetta Mannini, Laura S. Itzhaki, Tuomas P. J. Knowles, Christopher M. Dobson, Nunilo Cremades, Janet R. Kumita
Published 2022-02-01

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.

by Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Susan L Roy, Mitali A Tambe, Jean-Christophe Rochet, Celine Galvagnion, Gaia Skibinski, Steven Finkbeiner, Michael Bova, Karin Regnstrom, San-San Chiou, Jennifer Johnston, Kari Callaway, John P Anderson, Michael F Jobling, Alexander K Buell, Ted A Yednock, Tuomas P J Knowles, Michele Vendruscolo, John Christodoulou, Christopher M Dobson, Dale Schenk, Lisa McConlogue
Published 2014-01-01