Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures

by Tatsuya Ikenoue, Francesco A. Aprile, Francesco A. Aprile, Pietro Sormanni, Michele Vendruscolo
Published 2021-02-01

Natural Inhibitors of Amyloid Aggregation

by Paolo Tortora, Francesco A. Aprile
Published 2023-08-01

A Facile Method to Produce N-Terminally Truncated α-Synuclein

by Rebecca J. Thrush, Rebecca J. Thrush, Devkee M. Vadukul, Francesco A. Aprile, Francesco A. Aprile
Published 2022-05-01

Structure of a low-population intermediate state in the release of an enzyme product

by Alfonso De Simone, Francesco A Aprile, Anne Dhulesia, Christopher M Dobson, Michele Vendruscolo
Published 2015-01-01

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

by Francesco A. Aprile, Emma Källstig, Galina Limorenko, Michele Vendruscolo, David Ron, Christian Hansen
Published 2017-08-01

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF

by Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella
Published 2024-01-01

The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli.

by Gaetano Invernizzi, Francesco A Aprile, Antonino Natalello, Andrea Ghisleni, Amanda Penco, Annalisa Relini, Silvia M Doglia, Paolo Tortora, Maria E Regonesi
Published 2012-01-01

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.

by Francesco A Aprile, Anne Dhulesia, Florian Stengel, Cintia Roodveldt, Justin L P Benesch, Paolo Tortora, Carol V Robinson, Xavier Salvatella, Christopher M Dobson, Nunilo Cremades
Published 2013-01-01

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

by Philip R. Lindstedt, Francesco A. Aprile, Maria J. Matos, Michele Perni, Jean B. Bertoldo, Barbara Bernardim, Quentin Peter, Gonzalo Jiménez-Osés, Tuomas P. J. Knowles, Christopher M. Dobson, Francisco Corzana, Michele Vendruscolo, Gonçalo J. L. Bernardes
Published 2019-07-01

Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers

by Ryan Limbocker, Benedetta Mannini, Rodrigo Cataldi, Shianne Chhangur, Aidan K. Wright, Ryan P. Kreiser, J. Alex Albright, Sean Chia, Johnny Habchi, Pietro Sormanni, Janet R. Kumita, Francesco S. Ruggeri, Christopher M. Dobson, Fabrizio Chiti, Francesco A. Aprile, Michele Vendruscolo
Published 2020-06-01

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

by Suman De, Daniel R. Whiten, Francesco S. Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Published 2019-07-01

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

by Suman De, David C. Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A. Aprile, Francesco S. Ruggeri, Daniel R. Whiten, Derya Emin, Zengjie Xia, Juan A. Varela, Pietro Sormanni, Franziska Kundel, Tuomas P. J. Knowles, Christopher M. Dobson, Clare Bryant, Michele Vendruscolo, David Klenerman
Published 2019-04-01

The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

by Federica Raguseo, Yiran Wang, Jessica Li, Marija Petrić Howe, Rubika Balendra, Anouk Huyghebaert, Devkee M. Vadukul, Diana A. Tanase, Thomas E. Maher, Layla Malouf, Roger Rubio-Sánchez, Francesco A. Aprile, Yuval Elani, Rickie Patani, Lorenzo Di Michele, Marco Di Antonio
Published 2023-12-01

Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease

by Michele Perni, Annemieke van der Goot, Ryan Limbocker, Ryan Limbocker, Tjakko J. van Ham, Francesco A. Aprile, Catherine K. Xu, Patrick Flagmeier, Karen Thijssen, Pietro Sormanni, Giuliana Fusco, Serene W. Chen, Pavan K. Challa, Julius B. Kirkegaard, Romain F. Laine, Kai Yu Ma, Kai Yu Ma, Martin B. D. Müller, Martin B. D. Müller, Tessa Sinnige, Janet R. Kumita, Samuel I. A. Cohen, Renée Seinstra, Gabriele S. Kaminski Schierle, Clemens F. Kaminski, Denise Barbut, Alfonso De Simone, Tuomas P. J. Knowles, Michael Zasloff, Ellen A. A. Nollen, Michele Vendruscolo, Christopher M. Dobson
Published 2021-03-01

Methods of probing the interactions between small molecules and disordered proteins

by Heller, GT, Aprile, FA, Vendruscolo, M
Published 2017

Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures.

by Ikenoue, Tatsuya, Aprile, Francesco A, Sormanni, Pietro, Vendruscolo, Michele
Published 2021