Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules

by Jianjian Jin, Nikolaos Gkitsas, Vicki S. Fellowes, Jiaqiang Ren, Steven A. Feldman, Christian S. Hinrichs, David F. Stroncek, Steven L. Highfill
Published 2018-01-01

Cancer targeting by TCR gene-engineered T cells directed against Kita-Kyushu Lung Cancer Antigen-1

by Bridget Marcinkowski, Sanja Stevanović, Sarah R. Helman, Scott M. Norberg, Carylinda Serna, Benjamin Jin, Nikolaos Gkitsas, Tejas Kadakia, Andrew Warner, Jeremy L. Davis, Lisa Rooper, Christian S. Hinrichs
Published 2019-08-01

Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control

by Yihua Cai, Michaela Prochazkova, Chunjie Jiang, Hannah W. Song, Jianjian Jin, Larry Moses, Nikolaos Gkitsas, Robert P. Somerville, Steven L. Highfill, Sandhya Panch, David F. Stroncek, Ping Jin
Published 2021-12-01

Application of droplet digital PCR for the detection of vector copy number in clinical CAR/TCR T cell products

by Alex Lu, Hui Liu, Rongye Shi, Yihua Cai, Jinxia Ma, Lipei Shao, Victor Rong, Nikolaos Gkitsas, Hong Lei, Steven L. Highfill, Sandhya Panch, David F. Stroncek, Ping Jin
Published 2020-05-01

Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing

by Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G. Mancini, Gavin L. Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J. Fisher, Annie K. Brown, Ramya H. Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L. Mackall, Steven A. Feldman
Published 2023-06-01

275 Inosine endows CAR T cells with features of increased stemness and anti-tumor potency

by Katalin Sandor, Peng Xu, Jing Huang, Steven A Feldman, Nikolaos Gkitsas, Crystal L Mackall, Bence Daniel, Dorota Klysz, Malek Bashti, Elena Sotillo, Ansuman T Satpathy, Carley Fowler, Meena Malipatlolla, Lucille Stuani, Katherine A Freitas, Stefanie Meier, Louai Labanieh, Amaury Leruste, Janette Mata-Alcazar, Vimal Keerthi, Justin A Guerrero, Chris Fisher, Sunny Patel, Kyle Asano, Shabnum Patel, Kara L Davis
Published 2023-11-01