Increased functional stability and homogeneity of viral envelope spikes through directed evolution.

by Daniel P Leaman, Michael B Zwick
Published 2013-02-01

Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization.

by Arthur S Kim, Daniel P Leaman, Michael B Zwick
Published 2014-07-01

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells

by Jidnyasa Ingale, Armando Stano, Javier Guenaga, Shailendra Kumar Sharma, David Nemazee, Michael B. Zwick, Richard T. Wyatt
Published 2016-05-01

A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals.

by Laura M Walker, Melissa D Simek, Frances Priddy, Johannes S Gach, Denise Wagner, Michael B Zwick, Sanjay K Phogat, Pascal Poignard, Dennis R Burton
Published 2010-08-01

A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.

by Johannes S Gach, Heribert Quendler, Tommy Tong, Kristin M Narayan, Sean X Du, Robert G Whalen, James M Binley, Donald N Forthal, Pascal Poignard, Michael B Zwick
Published 2013-01-01

Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1).

by Nitish Agrawal, Daniel P Leaman, Eric Rowcliffe, Heather Kinkead, Raman Nohria, Junya Akagi, Katherine Bauer, Sean X Du, Robert G Whalen, Dennis R Burton, Michael B Zwick
Published 2011-01-01

Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate.

by Kristin M Narayan, Nitish Agrawal, Sean X Du, Janelle E Muranaka, Katherine Bauer, Daniel P Leaman, Pham Phung, Kay Limoli, Helen Chen, Rebecca I Boenig, Terri Wrin, Michael B Zwick, Robert G Whalen
Published 2013-01-01

4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms.

by Kyle J Nakamura, Johannes S Gach, Laura Jones, Katherine Semrau, Jan Walter, Frederic Bibollet-Ruche, Julie M Decker, Laura Heath, William D Decker, Moses Sinkala, Chipepo Kankasa, Donald Thea, James Mullins, Louise Kuhn, Michael B Zwick, Grace M Aldrovandi
Published 2010-03-01

A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein.

by Sean X Du, Li Xu, Wenge Zhang, Susan Tang, Rebecca I Boenig, Helen Chen, Ellaine B Mariano, Michael B Zwick, Paul W H I Parren, Dennis R Burton, Terri Wrin, Christos J Petropoulos, John A Ballantyne, Michael Chambers, Robert G Whalen
Published 2011-01-01

A lentiviral vector B cell gene therapy platform for the delivery of the anti-HIV-1 eCD4-Ig-knob-in-hole-reversed immunoadhesin

by Eirini Vamva, Stosh Ozog, Daniel P. Leaman, Rene Yu-Hong Cheng, Nicholas J. Irons, Andee Ott, Claire Stoffers, Iram Khan, Geraldine K.E. Goebrecht, Matthew R. Gardner, Michael Farzan, David J. Rawlings, Michael B. Zwick, Richard G. James, Bruce E. Torbett
Published 2023-03-01

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

by Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel García-Porras, Eneko Largo, Izaskun Morillo, Rubén Sánchez-Eugenia, Lei Zhang, Hong Cui, Ibon Iloro, Félix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B. Zwick, Jose M.M. Caaveiro, José L. Nieva
Published 2021-09-01

An MPER antibody neutralizes HIV-1 using germline features shared among donors

by Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, Michael B. Zwick
Published 2019-11-01

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

by Kimmo Rantalainen, Zachary T. Berndsen, Aleksandar Antanasijevic, Torben Schiffner, Xi Zhang, Wen-Hsin Lee, Jonathan L. Torres, Lei Zhang, Adriana Irimia, Jeffrey Copps, Kenneth H. Zhou, Young D. Kwon, William H. Law, Chaim A. Schramm, Raffaello Verardi, Shelly J. Krebs, Peter D. Kwong, Nicole A. Doria-Rose, Ian A. Wilson, Michael B. Zwick, John R. Yates, III, William R. Schief, Andrew B. Ward
Published 2020-04-01