Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells

by Sam Blanchett, Yves Dondelinger, Yves Dondelinger, Alessandro Barbarulo, Mathieu J. M. Bertrand, Mathieu J. M. Bertrand, Benedict Seddon
Published 2022-12-01

From PERK to RIPK1: Design, synthesis and evaluation of novel potent and selective necroptosis inhibitors

by Camilla Scarpellini, Sophie Valembois, Kenneth Goossens, Mike Vadi, Mike Vadi, Caroline Lanthier, Greta Klejborowska, Pieter Van Der Veken, Hans De Winter, Mathieu J. M. Bertrand, Mathieu J. M. Bertrand, Koen Augustyns
Published 2023-04-01

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

by Yves Dondelinger, Dario Priem, Jon Huyghe, Tom Delanghe, Peter Vandenabeele, Mathieu J. M. Bertrand
Published 2023-11-01

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

by Mathieu J M Bertrand, Saskia Lippens, An Staes, Barbara Gilbert, Ria Roelandt, Jelle De Medts, Kris Gevaert, Wim Declercq, Peter Vandenabeele
Published 2011-01-01

RIPK1 protects hepatocytes from death in Fas-induced hepatitis

by Aveline Filliol, Muhammad Farooq, Claire Piquet-Pellorce, Valentine Genet, Marie-Thérèse Dimanche-Boitrel, Peter Vandenabeele, Mathieu J. M. Bertrand, Michel Samson, Jacques Le Seyec
Published 2017-08-01

The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach

by Pauline Puylaert, Isabelle Coornaert, Cédric H. G. Neutel, Yves Dondelinger, Tom Delanghe, Mathieu J. M. Bertrand, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Published 2022-04-01

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

by Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Published 2020-04-01

Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis

by Bram Laukens, Claudia Jennewein, Barbara Schenk, Nele Vanlangenakker, Alexander Schier, Silvia Cristofanon, Kerry Zobel, Kurt Deshayes, Domagoj Vucic, Irmela Jeremias, Mathieu J.M. Bertrand, Peter Vandenabeele, Simone Fulda
Published 2011-10-01

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

by Tom Delanghe, Jon Huyghe, Seungheon Lee, Dario Priem, Samya Van Coillie, Barbara Gilbert, Sze Men Choi, Peter Vandenabeele, Alexei Degterev, Gregory D. Cuny, Yves Dondelinger, Mathieu J. M. Bertrand
Published 2021-07-01

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

by Yves Dondelinger, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves, Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A. Sehon, Robert W. Marquis, John Bertin, Peter J. Gough, Savvas Savvides, Jean-Claude Martinou, Mathieu J.M. Bertrand, Peter Vandenabeele
Published 2014-05-01

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

by Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand
Published 2019-04-01

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis

by Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Lisette Van Hove, Sofie Voet, Jana Roels, Jonathan Maelfait, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Yvan Saeys, Manolis Pasparakis, Mathieu J.M. Bertrand, Geert van Loo
Published 2020-02-01

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

by Tania Løve Aaes, Agnieszka Kaczmarek, Tinneke Delvaeye, Bram De Craene, Stefaan De Koker, Liesbeth Heyndrickx, Iris Delrue, Joachim Taminau, Bartosz Wiernicki, Philippe De Groote, Abhishek D. Garg, Luc Leybaert, Johan Grooten, Mathieu J.M. Bertrand, Patrizia Agostinis, Geert Berx, Wim Declercq, Peter Vandenabeele, Dmitri V. Krysko
Published 2016-04-01

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

by Luigi Tortola, Roberto Nitsch, Mathieu J.M. Bertrand, Melanie Kogler, Younes Redouane, Ivona Kozieradzki, Iris Uribesalgo, Lilian M. Fennell, Mads Daugaard, Helene Klug, Gerald Wirnsberger, Reiner Wimmer, Thomas Perlot, Renu Sarao, Shuan Rao, Toshikatsu Hanada, Nozomi Takahashi, Elisabeth Kernbauer, Duygu Demiröz, Michaela Lang, Giulio Superti-Furga, Thomas Decker, Andrea Pichler, Fumiyo Ikeda, Guido Kroemer, Peter Vandenabeele, Poul H. Sorensen, Josef M. Penninger
Published 2016-05-01

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

by Luigi Tortola, Roberto Nitsch, Mathieu J.M. Bertrand, Melanie Kogler, Younes Redouane, Ivona Kozieradzki, Iris Uribesalgo, Lilian M. Fennell, Mads Daugaard, Helene Klug, Gerald Wirnsberger, Reiner Wimmer, Thomas Perlot, Renu Sarao, Shuan Rao, Toshikatsu Hanada, Nozomi Takahashi, Elisabeth Kernbauer, Duygu Demiröz, Michaela Lang, Giulio Superti-Furga, Thomas Decker, Andrea Pichler, Fumiyo Ikeda, Guido Kroemer, Peter Vandenabeele, Poul H. Sorensen, Josef M. Penninger
Published 2016-09-01