ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

by Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev, Alexander Poltorak
Published 2021-01-01

Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.

by Colleen R McNamara, Ruchita Ahuja, Awo D Osafo-Addo, Douglas Barrows, Arminja Kettenbach, Igor Skidan, Xin Teng, Gregory D Cuny, Scott Gerber, Alexei Degterev
Published 2013-01-01

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

by Tom Delanghe, Jon Huyghe, Seungheon Lee, Dario Priem, Samya Van Coillie, Barbara Gilbert, Sze Men Choi, Peter Vandenabeele, Alexei Degterev, Gregory D. Cuny, Yves Dondelinger, Mathieu J. M. Bertrand
Published 2021-07-01

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation

by Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak
Published 2020-01-01

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1

by Malek Najjar, Chalada Suebsuwong, Soumya S. Ray, Roshan J. Thapa, Jenny L. Maki, Shoko Nogusa, Saumil Shah, Danish Saleh, Peter J. Gough, John Bertin, Junying Yuan, Siddharth Balachandran, Gregory D. Cuny, Alexei Degterev
Published 2015-03-01

Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis

by Limin Wu, Joon Yong Chung, Tian Cao, Gina Jin, William J. Edmiston, Suzanne Hickman, Emily S. Levy, Jordyn A. Whalen, Eliza Sophie LaRovere Abrams, Alexei Degterev, Eng H. Lo, Lorenzo Tozzi, David L. Kaplan, Joseph El Khoury, Michael J. Whalen
Published 2021-11-01

A genome-wide RNAi screen reveals multiple regulators of caspase activation

by Yi, Caroline H., Sogah, Dodzie K., Boyce, Michael, Degterev, Alexei, Christofferson, Dana E., Yuan, Junying
Published 2019

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1

by Shibata, Mamoru, Lu, Tao, Furuya, Tsuyoshi, Degterev, Alexei, Mizushima, Noboru, Yoshimori, Tamotsu, MacDonald, Marcy, Yankner, Bruce, Yuan, Junying
Published 2019

Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis

by McNamara, Colleen R., Ahuja, Ruchita, Osafo-Addo, Awo D., Barrows, Douglas, Kettenbach, Arminja, Skidan, Igor, Teng, Xin, Cuny, Gregory Douglas, Gerber, Scott, Degterev, Alexei
Published 2013

Inhibition of Cell Migration by PITENINs: The Role of ARF6

by Miao, Benchun, Skidan, Igor, Yang, Jinsheng, You, Zerong, Fu, Xueyan, Famulok, Michael, Schaffhausen, Brian, Torchilin, Vladimir, Yuan, Junying, Degterev, Alexei
Published 2013