CRISPR screening identifies T cell-intrinsic regulators of CD3-bispecific antibody responses

by Ryan D. Molony, Theresa Funk, Gina Trabucco, Erik Corcoran, David Ruddy, Malini Varadarajan, GiNell Elliot, Michelle Piquet, Joni Lam, Matthew J. Meyer, Hui Qin Wang, Sema Kurtulus, Haihui Lu
Published 2022-08-01

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

by Peter Tsvetkov, Marc L Mendillo, Jinghui Zhao, Jan E Carette, Parker H Merrill, Domagoj Cikes, Malini Varadarajan, Ferdy R van Diemen, Josef M Penninger, Alfred L Goldberg, Thijn R Brummelkamp, Sandro Santagata, Susan Lindquist
Published 2015-09-01

Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons

by Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood
Published 2021-06-01

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

by Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez, Wei Guan, Simon Liang, Jiyoung Elizabeth Choi, Minying Pu, Dongshu Chen, Tyler Laszewski, Stephanie Schwartz, Jane Gu, Leandra Mansur, Tyler Burks, Lauren Brodeur, Roberto Velazquez, Steve Kovats, Bhavesh Pant, Giri Buruzula, Emily Deng, Julie T. Chen, Farid Sari-Sarraf, Christina Dornelas, Malini Varadarajan, Haiyan Yu, Chen Liu, Joanne Lim, Huai-Xiang Hao, Xiaomo Jiang, Anthony Malamas, Matthew J. LaMarche, Felipe Correa Geyer, Margaret McLaughlin, Carlotta Costa, Joel Wagner, David Ruddy, Pushpa Jayaraman, Nathaniel D. Kirkpatrick, Pu Zhang, Oleg Iartchouk, Kimberly Aardalen, Viviana Cremasco, Glenn Dranoff, Jeffrey A. Engelman, Serena Silver, Hongyun Wang, William D. Hastings, Silvia Goldoni
Published 2021-01-01

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

by Tsvetkov, Peter, Zhao, Jinghui, Cikes, Domagoj, Varadarajan, Malini, Santagata, Sandro, Lindquist, Susan, Mendillo, Marc L., Carette, Jan E., Merrill, Parker H., van Diemen, Ferdy R., Penninger, Josef M., Goldberg, Alfred L., Brummelkamp, Thijn R.
Published 2015