Can T Cells Abort SARS-CoV-2 and Other Viral Infections?

by Leo Swadling, Mala K. Maini
Published 2023-02-01

Adaptive Reconfiguration of Natural Killer Cells in HIV-1 Infection

by Dimitra Peppa, Dimitra Peppa, Dimitra Peppa, Isabela Pedroza-Pacheco, Pierre Pellegrino, Ian Williams, Mala K. Maini, Persephone Borrow
Published 2018-03-01

Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo.

by Upkar S Gill, Dimitra Peppa, Lorenzo Micco, Harsimran D Singh, Ivana Carey, Graham R Foster, Mala K Maini, Patrick T F Kennedy
Published 2016-08-01

The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells.

by Anna Schurich, Laura J Pallett, Marcin Lubowiecki, Harsimran D Singh, Upkar S Gill, Patrick T Kennedy, Eleni Nastouli, Sudeep Tanwar, William Rosenberg, Mala K Maini
Published 2013-03-01

ULBP1 Is Elevated in Human Hepatocellular Carcinoma and Predicts Outcome

by Nicholas J. W. Easom, Nicholas J. W. Easom, Michael Marks, Dawda Jobe, Roopinder Gillmore, Tim Meyer, Tim Meyer, Mala K. Maini, Ramou Njie
Published 2020-06-01

CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity

by Roland Preece, Andrea Pavesi, Soragia Athina Gkazi, Kerstin A. Stegmann, Christos Georgiadis, Zhi Ming Tan, Jia Ying Joey Aw, Mala K. Maini, Antonio Bertoletti, Waseem Qasim
Published 2020-12-01

Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection.

by Dimitra Peppa, Lorenzo Micco, Alia Javaid, Patrick T F Kennedy, Anna Schurich, Claire Dunn, Celeste Pallant, Gidon Ellis, Pooja Khanna, Geoffrey Dusheiko, Richard J Gilson, Mala K Maini
Published 2010-12-01

Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.

by Gaia Nebbia, Dimitra Peppa, Anna Schurich, Pooja Khanna, Harsimran D Singh, Yang Cheng, William Rosenberg, Geoffrey Dusheiko, Richard Gilson, Joanne ChinAleong, Patrick Kennedy, Mala K Maini
Published 2012-01-01

The Design and Development of a Multi-HBV Antigen Encoded in Chimpanzee Adenoviral and Modified Vaccinia Ankara Viral Vectors; A Novel Therapeutic Vaccine Strategy against HBV

by Senthil K. Chinnakannan, Tamsin N. Cargill, Timothy A. Donnison, M. Azim Ansari, Sarah Sebastian, Lian Ni Lee, Claire Hutchings, Paul Klenerman, Mala K. Maini, Tom Evans, Eleanor Barnes
Published 2020-04-01

Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection.

by Adam J Gehring, Sarene Koh, Adeline Chia, Komathi Paramasivam, Valerie Suk Peng Chew, Zi Zong Ho, Kang Hoe Lee, Mala K Maini, Krishnakumar Madhavan, Seng Gee Lim, Antonio Bertoletti
Published 2011-01-01

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

by Anna Schurich, Laura J. Pallett, Danyal Jajbhay, Jessica Wijngaarden, Itziar Otano, Upkar S. Gill, Navjyot Hansi, Patrick T. Kennedy, Eleni Nastouli, Richard Gilson, Christian Frezza, Sian M. Henson, Mala K. Maini
Published 2016-08-01

Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma

by Nekisa Zakeri, Andrew Hall, Leo Swadling, Laura J. Pallett, Nathalie M. Schmidt, Mariana O. Diniz, Stephanie Kucykowicz, Oliver E. Amin, Amir Gander, Massimo Pinzani, Brian R. Davidson, Alberto Quaglia, Mala K. Maini
Published 2022-03-01

IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction

by Nicholas J. W. Easom, Kerstin A. Stegmann, Leo Swadling, Laura J. Pallett, Alice R. Burton, Dennis Odera, Nathalie Schmidt, Wei-Chen Huang, Wei-Chen Huang, Giuseppe Fusai, Brian Davidson, Mala K. Maini
Published 2018-05-01

TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis

by Harsimran D. Singh, Itziar Otano, Krista Rombouts, Kasha P. Singh, Dimitra Peppa, Upkar S. Gill, Katrin Böttcher, Patrick T. F. Kennedy, Jude Oben, Massimo Pinzani, Henning Walczak, Giuseppe Fusai, William M. C. Rosenberg, Mala K. Maini
Published 2017-07-01

Isolation of human intrahepatic leukocytes for phenotypic and functional characterization by flow cytometry

by Stephanie Kucykowicz, Oliver E. Amin, Alice R. Burton, Leo Swadling, Nathalie M. Schmidt, Nekisa Zakeri, Jessica Davies, Gloryanne Aidoo-Micah, Kerstin A. Stegmann, Nicholas J. Easom, Anna Jeffery-Smith, Mala K. Maini, Laura J. Pallett
Published 2022-06-01

SARS-CoV-2–specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodies

by Anna Jeffery-Smith, Alice R. Burton, Sabela Lens, Chloe Rees-Spear, Jessica Davies, Monika Patel, Robin Gopal, Luke Muir, Felicity Aiano, Katie J. Doores, J. Yimmy Chow, Shamez N. Ladhani, Maria Zambon, Laura E. McCoy, Mala K. Maini
Published 2022-01-01

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

by Daniel M. Altmann, Catherine J. Reynolds, George Joy, Ashley D. Otter, Joseph M. Gibbons, Corinna Pade, Leo Swadling, Mala K. Maini, Tim Brooks, Amanda Semper, Áine McKnight, Mahdad Noursadeghi, Charlotte Manisty, Thomas A. Treibel, James C. Moon, COVIDsortium investigators, Rosemary J. Boyton
Published 2023-08-01

An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity.

by Peter A C Wing, Nathalie M Schmidt, Rory Peters, Maximilian Erdmann, Rachel Brown, Hao Wang, Leo Swadling, COVIDsortium Investigators, Joseph Newman, Nazia Thakur, Kaho Shionoya, Sophie B Morgan, Timothy Sc Hinks, Koichi Watashi, Dalan Bailey, Scott B Hansen, Andrew D Davidson, Mala K Maini, Jane A McKeating
Published 2023-05-01

Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

by Elena Mitsi, Mariana O. Diniz, Jesús Reiné, Andrea M. Collins, Ryan E. Robinson, Angela Hyder-Wright, Madlen Farrar, Konstantinos Liatsikos, Josh Hamilton, Onyia Onyema, Britta C. Urban, Carla Solórzano, Sandra Belij-Rammerstorfer, Emma Sheehan, Teresa Lambe, Simon J. Draper, Daniela Weiskopf, Alessandro Sette, Mala K. Maini, Daniela M. Ferreira
Published 2023-10-01

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

by Leo Swadling, Laura J. Pallett, Mariana O. Diniz, Josephine M. Baker, Oliver E. Amin, Kerstin A. Stegmann, Alice R. Burton, Nathalie M. Schmidt, Anna Jeffery-Smith, Nekisa Zakeri, Kornelija Suveizdyte, Farid Froghi, Giuseppe Fusai, William M. Rosenberg, Brian R. Davidson, Anna Schurich, A. Katharina Simon, Mala K. Maini
Published 2020-01-01