Genome and metabolome: chance and necessity

by Emanuel Gonçalves, Christian Frezza
Published 2021-09-01

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

by Edoardo Gaude, Christian Frezza
Published 2016-10-01

Mitochondrial DNA: the overlooked oncogenome?

by Payam A. Gammage, Christian Frezza
Published 2019-07-01

Astrocyte power fuels neurons during stroke

by Stefano Pluchino, Luca Peruzzotti-Jametti, Christian Frezza
Published 2016-11-01

Identification of Methylated Deoxyadenosines in Genomic DNA by dA6m DNA Immunoprecipitation

by Magdalena Koziol, Charles Bradshaw, George Allen, Ana Costa, Christian Frezza
Published 2016-11-01

CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism

by Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai, Margaret Ashcroft
Published 2019-07-01

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival.

by Christian Frezza, Liang Zheng, Daniel A Tennant, Dmitri B Papkovsky, Barbara A Hedley, Gabriela Kalna, David G Watson, Eyal Gottlieb
Published 2011-01-01

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

by Keren Yizhak, Edoardo Gaude, Sylvia Le Dévédec, Yedael Y Waldman, Gideon Y Stein, Bob van de Water, Christian Frezza, Eytan Ruppin
Published 2014-11-01

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

by Keren Yizhak, Sylvia E Le Dévédec, Vasiliki Maria Rogkoti, Franziska Baenke, Vincent C deBoer, Christian Frezza, Almut Schulze, Bob van deWater, Eytan Ruppin
Published 2014-11-01

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex

by Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan
Published 2020-08-01

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

by Keren Yizhak, Sylvia E Le Dévédec, Vasiliki Maria Rogkoti, Franziska Baenke, Vincent C deBoer, Christian Frezza, Almut Schulze, Bob van deWater, Eytan Ruppin
Published 2014-08-01

Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis

by John S. O’ Neill, Nathaniel P. Hoyle, J. Brian Robertson, Rachel S. Edgar, Andrew D. Beale, Sew Y. Peak-Chew, Jason Day, Ana S. H. Costa, Christian Frezza, Helen C. Causton
Published 2020-09-01

Author Correction: Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis

by John S. O’Neill, Nathaniel P. Hoyle, J. Brian Robertson, Rachel S. Edgar, Andrew D. Beale, Sew Y. Peak-Chew, Jason Day, Ana S. H. Costa, Christian Frezza, Helen C. Causton
Published 2021-12-01

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

by Anna Schurich, Laura J. Pallett, Danyal Jajbhay, Jessica Wijngaarden, Itziar Otano, Upkar S. Gill, Navjyot Hansi, Patrick T. Kennedy, Eleni Nastouli, Richard Gilson, Christian Frezza, Sian M. Henson, Mala K. Maini
Published 2016-08-01

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells

by Ana Carolina B. Sant’Anna-Silva, Juan A. Perez-Valencia, Marco Sciacovelli, Claude Lalou, Saharnaz Sarlak, Laura Tronci, Efterpi Nikitopoulou, Andras T. Meszaros, Christian Frezza, Rodrigue Rossignol, Erich Gnaiger, Helmut Klocker
Published 2021-04-01

FOXA2 controls the anti-oxidant response in FH-deficient cells

by Connor Rogerson, Marco Sciacovelli, Lucas A. Maddalena, Andromachi Pouikli, Marc Segarra-Mondejar, Lorea Valcarcel-Jimenez, Christina Schmidt, Ming Yang, Elena Ivanova, Joshua Kent, Ariane Mora, Danya Cheeseman, Jason S. Carroll, Gavin Kelsey, Christian Frezza
Published 2023-07-01

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects

by Petros A. Tyrakis, Marie E. Yurkovich, Marco Sciacovelli, Evangelia K. Papachristou, Hannah R. Bridges, Edoardo Gaude, Alexander Schreiner, Clive D’Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R. Griffiths, Christian Frezza
Published 2017-10-01

Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

by Matthias Kohlhauer, Sam Dawkins, Ana S. H. Costa, Regent Lee, Timothy Young, Victoria R. Pell, Robin P. Choudhury, Adrian P. Banning, Rajesh K. Kharbanda, Kourosh Saeb‐Parsy, Michael P. Murphy, Christian Frezza, Thomas Krieg, Keith M. Channon
Published 2018-04-01

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

by Dylan Gerard Ryan, Ming Yang, Hiran A Prag, Giovanny Rodriguez Blanco, Efterpi Nikitopoulou, Marc Segarra-Mondejar, Christopher A Powell, Tim Young, Nils Burger, Jan Lj Miljkovic, Michal Minczuk, Michael P Murphy, Alex von Kriegsheim, Christian Frezza
Published 2021-12-01

Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo

by Marie Pereira, Tai-Di Chen, Norzawani Buang, Antoni Olona, Jeong-Hun Ko, Maria Prendecki, Ana S.H. Costa, Efterpi Nikitopoulou, Laura Tronci, Charles D. Pusey, H. Terence Cook, Stephen P. McAdoo, Christian Frezza, Jacques Behmoaras
Published 2019-07-01