The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations

by Leonard Ndwiga, Victor Osoti, Kevin Omondi Ochwedo, Kevin Wamae, Philip Bejon, Julian C. Rayner, George Githinji, Lynette Isabella Ochola-Oyier
Published 2021-06-01

Low frequency of Plasmodium falciparum hrp2/3 deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya

by Dorcas Okanda, Leonard Ndwiga, Victor Osoti, Nicole Achieng, Juliana Wambua, Caroline Ngetsa, Peter Lubell-Doughtie, Anuraj Shankar, Philip Bejon, Philip Bejon, Lynette Isabella Ochola-Oyier
Published 2023-02-01

Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018

by Kelvin M. Kimenyi, Kevin Wamae, Joyce M. Ngoi, Zaydah R. de Laurent, Leonard Ndwiga, Victor Osoti, George Obiero, Abdirahman I. Abdi, Philip Bejon, Lynette Isabella Ochola-Oyier
Published 2022-06-01

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 3; peer review: 2 approved, 2...

by Mainga Hamaluba, Juliana Wambua, Arjen M. Dondorp, Jennifer Musyoki, Caroline Ngetsa, Oksana Kharabora, Leonard Ndwiga, Zaydah de Laurent, Kevin Wamae, Kelvin Kimenyi, Gabriel Mwambingu, Peter Kalume, Philip Bejon, Jeffrey Bailey, Rob van der Pluijm, Lynette Ochola-Oyier, Jonathan Juliano, Victor Osoti
Published 2023-10-01

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 2; peer review: 2 approved, 1...

by Mainga Hamaluba, Juliana Wambua, Arjen M. Dondorp, Jennifer Musyoki, Caroline Ngetsa, Oksana Kharabora, Leonard Ndwiga, Zaydah de Laurent, Kevin Wamae, Kelvin Kimenyi, Gabriel Mwambingu, Peter Kalume, Philip Bejon, Jeffrey Bailey, Rob van der Pluijm, Lynette Ochola-Oyier, Jonathan Juliano, Victor Osoti
Published 2022-12-01

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 4; peer review: 2 approved, 2...

by Mainga Hamaluba, Juliana Wambua, Arjen M. Dondorp, Jennifer Musyoki, Caroline Ngetsa, Oksana Kharabora, Leonard Ndwiga, Zaydah de Laurent, Kevin Wamae, Kelvin Kimenyi, Gabriel Mwambingu, Peter Kalume, Philip Bejon, Jeffrey Bailey, Rob van der Pluijm, Lynette Ochola-Oyier, Jonathan Juliano, Victor Osoti
Published 2024-03-01

New SARS-CoV-2 Omicron Variant with Spike Protein Mutation Y451H, Kilifi, Kenya, March–May 2023

by Mike J. Mwanga, Arnold W. Lambisia, John Mwita Morobe, Nickson Murunga, Edidah Moraa, Leonard Ndwiga, Robinson Cheruiyot, Jennifer Musyoki, Martin Mutunga, Laura M. Guzman-Rincon, Charles Sande, Joseph Mwangangi, Philip Bejon, Lynette Isabella Ochola-Oyier, D. James Nokes, Charles N. Agoti, Joyce Nyiro, George Githinji
Published 2023-11-01

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa

by Leonard Ndwiga, Kelvin M. Kimenyi, Kevin Wamae, Victor Osoti, Mercy Akinyi, Irene Omedo, Deus S. Ishengoma, Nancy Duah-Quashie, Ben Andagalu, Anita Ghansah, Alfred Amambua-Ngwa, Stephen Tukwasibwe, Sofonias K. Tessema, Corine Karema, Abdoulaye A. Djimde, Arjen M. Dondorp, Jaishree Raman, Robert W. Snow, Philip Bejon, Lynette Isabella Ochola-Oyier
Published 2021-08-01

Optimization of the SARS-CoV-2 ARTIC Network V4 Primers and Whole Genome Sequencing Protocol

by Arnold W. Lambisia, Khadija S. Mohammed, Timothy O. Makori, Leonard Ndwiga, Maureen W. Mburu, John M. Morobe, Edidah O. Moraa, Jennifer Musyoki, Nickson Murunga, Jane N. Mwangi, D. James Nokes, D. James Nokes, Charles N. Agoti, Charles N. Agoti, Lynette Isabella Ochola-Oyier, Lynette Isabella Ochola-Oyier, George Githinji, George Githinji
Published 2022-02-01

Epidemiology of COVID-19 infections on routine polymerase chain reaction (PCR) and serology testing in Coastal Kenya [version 1; peer review: 2 approved]

by Henry Karanja, Daisy Mugo, D.J. Nokes, James Nyagwange, Lynette Isabella Ochola-Oyier, Kelvin Muteru, Leonard Ndwiga, Bernadette Kutima, Patrick Amoth, George Githinji, Kevin Wamae, Kadondi Kasera, Nickson Murunga, Lawrence Babu, Edwine Barasa, John Gitonga, Benjamin Tsofa, Philip Bejon, George Warimwe, James Tuju, Benedict Orindi, Charles N. Agoti, COVID testing team, Edward Otieno
Published 2022-02-01

Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: A retrospective genomic study

by Charles N Agoti, Lynette Isabella Ochola-Oyier, Simon Dellicour, Khadija Said Mohammed, Arnold W Lambisia, Zaydah R de Laurent, John M Morobe, Maureen W Mburu, Donwilliams O Omuoyo, Edidah M Ongera, Leonard Ndwiga, Eric Maitha, Benson Kitole, Thani Suleiman, Mohamed Mwakinangu, John K Nyambu, John Otieno, Barke Salim, Jennifer Musyoki, Nickson Murunga, Edward Otieno, John N Kiiru, Kadondi Kasera, Patrick Amoth, Mercy Mwangangi, Rashid Aman, Samson Kinyanjui, George Warimwe, My Phan, Ambrose Agweyu, Matthew Cotten, Edwine Barasa, Benjamin Tsofa, D James Nokes, Philip Bejon, George Githinji
Published 2022-06-01

Genomic Epidemiology of SARS-CoV-2 in Seychelles, 2020–2021

by John Mwita Morobe, Brigitte Pool, Lina Marie, Dwayne Didon, Arnold W. Lambisia, Timothy Makori, Khadija Said Mohammed, Zaydah R. de Laurent, Leonard Ndwiga, Maureen W. Mburu, Edidah Moraa, Nickson Murunga, Jennifer Musyoki, Jedida Mwacharo, Lydia Nyamako, Debra Riako, Pariken Ephnatus, Faith Gambo, Josephine Naimani, Joyce Namulondo, Susan Zimba Tembo, Edwin Ogendi, Thierno Balde, Fred Athanasius Dratibi, Ali Ahmed Yahaya, Nicksy Gumede, Rachel A. Achilla, Peter K. Borus, Dorcas W. Wanjohi, Sofonias K. Tessema, Joseph Mwangangi, Philip Bejon, David J. Nokes, Lynette Isabella Ochola-Oyier, George Githinji, Leon Biscornet, Charles N. Agoti
Published 2022-06-01

Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020-21.

by Ruth K Lucinde, Daisy Mugo, Christian Bottomley, Angela Karani, Elizabeth Gardiner, Rabia Aziza, John N Gitonga, Henry Karanja, James Nyagwange, James Tuju, Perpetual Wanjiku, Edward Nzomo, Evans Kamuri, Kaugiria Thuranira, Sarah Agunda, Gideon Nyutu, Anthony O Etyang, Ifedayo M O Adetifa, Eunice Kagucia, Sophie Uyoga, Mark Otiende, Edward Otieno, Leonard Ndwiga, Charles N Agoti, Rashid A Aman, Mercy Mwangangi, Patrick Amoth, Kadondi Kasera, Amek Nyaguara, Wangari Ng'ang'a, Lucy B Ochola, Emukule Namdala, Oscar Gaunya, Rosemary Okuku, Edwine Barasa, Philip Bejon, Benjamin Tsofa, L Isabella Ochola-Oyier, George M Warimwe, Ambrose Agweyu, J Anthony G Scott, Katherine E Gallagher
Published 2022-01-01

Sero-surveillance for IgG to SARS-CoV-2 at antenatal care clinics in three Kenyan referral hospitals: Repeated cross-sectional surveys 2020–21

by Ruth K. Lucinde, Daisy Mugo, Christian Bottomley, Angela Karani, Elizabeth Gardiner, Rabia Aziza, John N. Gitonga, Henry Karanja, James Nyagwange, James Tuju, Perpetual Wanjiku, Edward Nzomo, Evans Kamuri, Kaugiria Thuranira, Sarah Agunda, Gideon Nyutu, Anthony O. Etyang, Ifedayo M. O. Adetifa, Eunice Kagucia, Sophie Uyoga, Mark Otiende, Edward Otieno, Leonard Ndwiga, Charles N. Agoti, Rashid A. Aman, Mercy Mwangangi, Patrick Amoth, Kadondi Kasera, Amek Nyaguara, Wangari Ng’ang’a, Lucy B. Ochola, Emukule Namdala, Oscar Gaunya, Rosemary Okuku, Edwine Barasa, Philip Bejon, Benjamin Tsofa, L. Isabella Ochola-Oyier, George M. Warimwe, Ambrose Agweyu, J. Anthony G. Scott, Katherine E. Gallagher
Published 2022-01-01

An optimization of four SARS-CoV-2 qRT-PCR assays in a Kenyan laboratory to support the national COVID-19 rapid response teams [version 2; peer review: 2 approved]

by Shadrack Mutua, Brian Bartilol, Shaban J. Mwangi, Debra Riako, Lydia Nyamako, Bonface M. Gichuki, Henry Karanja, Angela Karani, John N. Gitonga, Daisy Mugo, Brian Tawa, Wilson Gumbi, Wesley Cheruiyot, Metrine Tendwa, John K. Nyambu, Yiakon Sein, Thani Suleiman Thani, Shem O. Patta, Benson Kitole, Eric K. Maitha, Barke S. Muslih, Mohamed S. Mwakinangu, Philip Bejon, Benjamin Tsofa, Joyce U. Nyiro, John Ochieng Otieno, Leonard Ndwiga, Patience Kiyuka, Johnstone Makale, Kevin Wamae, Victor Osoti, John Mwita Morobe, Calleb Odundo, Arnold W. Lambisia, Martin Mutunga, Salim Mwarumba, Lynette Isabella Ochola-Oyier, Charles N. Agoti, Clement Lewa, Elijah Gicheru, Jennifer Musyoki, Susan Njuguna, Horace Gumba, Domtila Kimani, Jedidah Mwacharo, Zaydah R. de Laurent, Khadija Said Mohammed, Robinson Cheruiyot, Donwilliams O. Omuoyo
Published 2022-03-01