LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation[S]

by Cornelia Pipper, Natalie Bordag, Bernadette Reiter, Kyriakos Economides, Peter Florian, Thomas Birngruber, Frank Sinner, Manfred Bodenlenz, Anita Eberl
Published 2019-04-01

572 Combination therapy of exoSTING, exoIL-12 activates systemic anti-tumor immunity

by Tong Zi, Sriram Sathyanaryanan, Katherine Kirwin, Kevin Dooley, Su Chul Jang, Kyriakos Economides, Yanyan Liu, Christine Sia, Kelvin Zhang, Shil Patel
Published 2021-11-01

842 Exosome mediated reprogramming of tumor associated macrophages by exoASO-STAT6 for the treatment of hepatocellular carcinoma (HCC)

by Tong Zi, Sriram Sathyanaryanan, Su Chul Jang, Kyriakos Economides, Dalia Burzyn, Charan Leng, Kelvin Zhang, Samuel Kasera, Sushrut Kamerkar, Olga Burenkova, Timothy Soos
Published 2021-11-01

1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules

by Christopher J Nirschl, Kyriakos Economides, Kristin Morris, Andres Salmeron, Daniel J Hicklin, Cynthia Seidel-Dugan, Kulandayan K Subramanian, Randi Isaacs, Sameer Chopra, Celesztina Domonkos
Published 2023-11-01

1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer

by Kyriakos Economides, Nesreen Ismail, Andres Salmeron, Jenna M Sullivan, Pam Aderhold, Heather R Brodkin, Celesztina Nagy-Domonkos, Daniel J Hicklin, Cynthia Seidel-Dugan, William M Winston
Published 2023-11-01

252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors

by Kyriakos Economides, Kristin Morris, Andres Salmeron, Connor J Dwyer, Heather R Brodkin, Daniel J Hicklin, Cynthia Seidel-Dugan, William M Winston, Olivia G Donovan, Julie LePrevost
Published 2023-11-01

761 exoSTING demonstrates potent anti-tumor activity in a mouse model of leptomeningeal disease

by Tong Zi, Sriram Sathyanarayanan, Katherine Kirwin, Su Chul Jang, Kyriakos Economides, John Lin, Kelvin Zhang, Shil Patel, Xudong Feng, Sevda Lule, Paloma Sanchez-Jauregui, Samuel Kasera, Silvia Siso, Wendy Broom
Published 2021-11-01

709 Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure

by Michael Doherty, Ke Xu, Tong Zi, Sriram Sathyanaryanan, Nuruddeen Lewis, Chang Ling Sia, Katherine Kirwin, Sonya Haupt, Gauri Mahimkar, Kevin Dooley, Su Chul Jang, Bryan Choi, Andrew Grube, Christine McCoy, Jorge Sanchez-Salazar, Scott Estes, Kyriakos Economides, Douglas Williams
Published 2020-11-01