715 WTX-330 is an IL-12 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models

by Christopher Nirschl, Kristin Morris, Heather Brodkin, Daniel Hicklin, Nesreen Ismail, Andres Salmeron, Philipp Steiner, Zoe Steuert, Jenna Sullivan, William Winston
Published 2021-11-01

718 WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives antitumor immunity in murine syngeneic cancer models

by Christopher Nirschl, Kristin Morris, Heather Brodkin, Daniel Hicklin, Nesreen Ismail, Andres Salmeron, Philipp Steiner, Zoe Steuert, Jenna Sullivan, William Winston, Cindy Seidel-Dugan
Published 2021-11-01

1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules

by Christopher J Nirschl, Kyriakos Economides, Kristin Morris, Andres Salmeron, Daniel J Hicklin, Cynthia Seidel-Dugan, Kulandayan K Subramanian, Randi Isaacs, Sameer Chopra, Celesztina Domonkos
Published 2023-11-01

252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors

by Kyriakos Economides, Kristin Morris, Andres Salmeron, Connor J Dwyer, Heather R Brodkin, Daniel J Hicklin, Cynthia Seidel-Dugan, William M Winston, Olivia G Donovan, Julie LePrevost
Published 2023-11-01

723 WTX-613, a conditionally activated IFNα INDUKINE™ molecule, induces anti-tumor immune responses resulting in strong tumor growth control in syngeneic mouse tumor models

by Christopher Nirschl, Kristin Morris, Heather Brodkin, Nesreen Ismail, Andres Salmeron, Philipp Steiner, Zoe Steuert, Jenna Sullivan, William Winston, Cindy Seidel-Dugan, Ethika Tyagi, Josue Canales, Dan Hicklin
Published 2021-11-01

737 A phase 1/1b study of the tumor-activated IL-2 prodrug WTX-124 alone or in combination with pembrolizumab in patients with immunotherapy-sensitive locally advanced or metastati...

by Brendan Curti, Igor Puzanov, Mateusz Opyrchal, Christopher J Nirschl, Mehmet A Bilen, Kristin Morris, Justin C Moser, Ildefonso Rodriguez Rivera, Saero Park, Marissa Bruno, Paul Windt, Kulandayan K Subramanian, Sameer S Chopra, Randi Isaacs
Published 2023-11-01