EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS.

by Claire E Le Pichon, Sara L Dominguez, Hilda Solanoy, Hai Ngu, Nicholas Lewin-Koh, Mark Chen, Jeffrey Eastham-Anderson, Ryan Watts, Kimberly Scearce-Levie
Published 2013-01-01

SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.

by Jesse E Hanson, Hank La, Emile Plise, Yung-Hsiang Chen, Xiao Ding, Taleen Hanania, Emily V Sabath, Vadim Alexandrov, Dani Brunner, Emer Leahy, Pascal Steiner, Lichuan Liu, Kimberly Scearce-Levie, Qiang Zhou
Published 2013-01-01

Longitudinal biomarkers in amyotrophic lateral sclerosis

by Fen Huang, Yuda Zhu, Jennifer Hsiao‐Nakamoto, Xinyan Tang, Jason C. Dugas, Miriam Moscovitch‐Lopatin, Jonathan D. Glass, Robert H. Brown Jr, Shafeeq S. Ladha, David Lacomis, Jeffrey M. Harris, Kimberly Scearce‐Levie, Carole Ho, Robert Bowser, James D. Berry
Published 2020-07-01

Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients

by Akhil Bhalla, Ritesh Ravi, Meng Fang, Annie Arguello, Sonnet S. Davis, Chi-Lu Chiu, Jessica R. Blumenfeld, Hoang N. Nguyen, Timothy K. Earr, Junhua Wang, Giuseppe Astarita, Yuda Zhu, Damian Fiore, Kimberly Scearce-Levie, Dolores Diaz, Heather Cahan, Matthew D. Troyer, Jeffrey M. Harris, Maria L. Escolar
Published 2020-07-01

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

by Seung-Hye Lee, Claire E. Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A. Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V. Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J. Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalon
Published 2016-08-01

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models

by Jesse E. Hanson, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, Abdullah S. Khan, Jeffrey Simms, Benjamin Liu, Thomas A. Kim, Gui-Qiu Yu, Yelin Chen, Tzu-Ming Wang, Zhiyu Jiang, Bianca M. Liederer, Gauri Deshmukh, Hilda Solanoy, Connie Chan, Benjamin D. Sellers, Matthew Volgraf, Jacob B. Schwarz, David H. Hackos, Robby M. Weimer, Morgan Sheng, T. Michael Gill, Kimberly Scearce-Levie, Jorge J. Palop
Published 2020-01-01

Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome

by Annie Arguello, René Meisner, Elliot R. Thomsen, Hoang N. Nguyen, Ritesh Ravi, Jeffrey Simms, Iris Lo, Jessica Speckart, Julia Holtzman, Thomas M. Gill, Darren Chan, Yuhsiang Cheng, Chi-Lu Chiu, Jason C. Dugas, Meng Fang, Isabel A. Lopez, Hilda Solanoy, Buyankhishig Tsogtbaatar, Yuda Zhu, Akhil Bhalla, Kirk R. Henne, Anastasia G. Henry, Anthony Delucchi, Simona Costanzo, Jeffrey M. Harris, Dolores Diaz, Kimberly Scearce-Levie, Pascal E. Sanchez
Published 2021-10-01

Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib...

by Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Jerome Oude Nijhuis, Peter Paul De Deyn, Salah Hadi, Jeffrey Harris, Richard M. Tsai, Andres Cruz‐Herranz, Fen Huang, Vincent Tong, Rebecca Erickson, Yuda Zhu, Kimberly Scearce‐Levie, Jennifer Hsiao‐Nakamoto, Xinyan Tang, Megan Chang, Brian M. Fox, Anthony A. Estrada, Robert J. Pomponio, Miguel Alonso‐Alonso, Moshe Zilberstein, Nazem Atassi, Matthew D. Troyer, Carole Ho
Published 2022-08-01

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

by Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Published 2022-06-01