The Novel Pimavanserin Derivative ST-2300 with Histamine H₃ Receptor Affinity Shows Reduced 5-HT_2A Binding, but Maintains Antidepressant- and Anxiolytic-like...

by Karthikkumar Venkatachalam, Sicheng Zhong, Mariam Dubiel, Grzegorz Satała, Bassem Sadek, Holger Stark
Published 2022-05-01

Experimental Studies Indicate That ST-2223, the Antagonist of Histamine H3 and Dopamine D2/D3 Receptors, Restores Social Deficits and Neurotransmission Dysregulation in Mouse Model...

by Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Priya Yuvaraju, Markus Falkenstein, Holger Stark, Bassem Sadek
Published 2022-07-01

The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions

by Karthikkumar Venkatachalam, Nermin Eissa, Mohamed Al Awad, Petrilla Jayaprakash, Sicheng Zhong, Frauke Stölting, Holger Stark, Bassem Sadek
Published 2021-06-01

Simultaneous Antagonism at H3R/D2R/D3R Reduces Autism-like Self-Grooming and Aggressive Behaviors by Mitigating MAPK Activation in Mice

by Nermin Eissa, Mohamed Al Awad, Shilu Deepa Thomas, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Sicheng Zhong, Holger Stark, Bassem Sadek
Published 2022-12-01

The Multi-Targeting Ligand ST-2223 with Histamine H₃ Receptor and Dopamine D₂/D₃ Receptor Antagonist Properties Mitigates Autism-Like Repetitive Be...

by Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Markus Falkenstein, Mariam Dubiel, Annika Frank, David Reiner-Link, Holger Stark, Bassem Sadek
Published 2021-02-01

Chemoprevention of Colon Cancer by DFMO, Sulindac, and NO-Sulindac Administered Individually or in Combinations in F344 Rats

by Venkateshwar Madka, Jagan M. R. Patlolla, Karthikkumar Venkatachalam, Yuting Zhang, Gopal Pathuri, Nicole Stratton, Stanley Lightfoot, Naveena B. Janakiram, Altaf Mohammed, Chinthalapally V. Rao
Published 2023-08-01