Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma

by Michael Hölzel, Johanna A Seier, Julia Reinhardt, Kritika Saraf, Susanna S Ng, Julian P Layer, Dillon Corvino, Kristina Althoff, Frank A Giordano, Alexander Schramm, Matthias Fischer
Published 2021-05-01

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

by Julian P. Layer, Marie T. Kronmüller, Thomas Quast, Debby van den Boorn-Konijnenberg, Maike Effern, Daniel Hinze, Kristina Althoff, Alexander Schramm, Frank Westermann, Martin Peifer, Gunther Hartmann, Thomas Tüting, Waldemar Kolanus, Matthias Fischer, Johannes Schulte, Michael Hölzel
Published 2017-06-01

Location of Recurrences after Trimodality Treatment for Glioblastoma with Respect to the Delivered Radiation Dose Distribution and Its Influence on Prognosis

by Nika Guberina, Florian Padeberg, Christoph Pöttgen, Maja Guberina, Lazaros Lazaridis, Ramazan Jabbarli, Cornelius Deuschl, Ken Herrmann, Tobias Blau, Karsten H. Wrede, Kathy Keyvani, Björn Scheffler, Jörg Hense, Julian P. Layer, Martin Glas, Ulrich Sure, Martin Stuschke
Published 2023-05-01

Five-Fraction Stereotactic Radiotherapy for Brain Metastases—A Retrospective Analysis

by Julian P. Layer, Katharina Layer, Gustavo R. Sarria, Fred Röhner, Cas S. Dejonckheere, Lea L. Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Mümtaz Köksal, Frederic Carsten Schmeel, Niklas Schäfer, Jennifer Landsberg, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano, Leonard Christopher Schmeel
Published 2023-01-01

Benchmarking Safety Indicators of Surgical Treatment of Brain Metastases Combined with Intraoperative Radiotherapy: Results of Prospective Observational Study with Comparative Matc...

by Motaz Hamed, Anna-Laura Potthoff, Julian P. Layer, David Koch, Valeri Borger, Muriel Heimann, Davide Scafa, Gustavo R. Sarria, Jasmin A. Holz, Frederic Carsten Schmeel, Alexander Radbruch, Erdem Güresir, Niklas Schäfer, Patrick Schuss, Stephan Garbe, Frank A. Giordano, Ulrich Herrlinger, Hartmut Vatter, Leonard Christopher Schmeel, Matthias Schneider
Published 2022-03-01

L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial

by Frank A. Giordano, Julian P. Layer, Sonia Leonardelli, Lea L. Friker, Roberta Turiello, Dillon Corvino, Thomas Zeyen, Christina Schaub, Wolf Müller, Elena Sperk, Leonard Christopher Schmeel, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Torsten Pietsch, Sotirios Bisdas, Michael Platten, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel
Published 2024-05-01

Image Guided Intraoperative Radiation Therapy After Surgical Resection of Brain Metastases: A First In-Human Feasibility Report

by Molina Grimmer, MSc, Gustavo R. Sarria, MD, Motaz Hamed, MD, Mohammed Banat, MD, Fabian Kugel, MSc, Hector Lorenzana, MHA, Davide Scafa, MD, Mümtaz Köksal, MD, Julian P. Layer, MD, Cas Dejonckheere, MD, Martin Fiebich, PhD, Frederic Carsten Schmeel, MD, Ana Kowark, MD, Hartmut Vatter, PhD, Leonard Christopher Schmeel, MD, Stephan Garbe, PhD
Published 2024-05-01