The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma.

by Xinqi Wu, Meijun Zhu, Jonathan A Fletcher, Anita Giobbie-Hurder, F Stephen Hodi
Published 2012-01-01

Comparative Gene Expression Profiling of Benign and Malignant Lesions Reveals Candidate Therapeutic Compounds for Leiomyosarcoma

by Badreddin Edris, Jonathan A. Fletcher, Robert B. West, Matt van de Rijn, Andrew H. Beck
Published 2012-01-01

Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor.

by Thomas Mühlenberg, Susanne Grunewald, Jürgen Treckmann, Lars Podleska, Martin Schuler, Jonathan A Fletcher, Sebastian Bauer
Published 2015-01-01

Targeted Inhibition of Multiple Receptor Tyrosine Kinases in Mesothelioma

by Wen-Bin Ou, Christopher Hubert, Jonathan A. Fletcher, Joseph M. Corson, Raphael Bueno, Daniel L. Flynn, David J. Sugarbaker
Published 2011-01-01

YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways

by Wen-Bin Ou, Meijun Z. Lundberg, Shuihao Zhu, Nacef Bahri, Anastasios Kyriazoglou, Liangliang Xu, Ting Chen, Adrian Mariño-Enriquez, Jonathan A. Fletcher
Published 2021-05-01

AXL Inactivation Inhibits Mesothelioma Growth and Migration via Regulation of p53 Expression

by Wei Song, Hao Wang, Minmin Lu, Xinxin Ni, Nacef Bahri, Shuihao Zhu, Limin Chen, Yuehong Wu, Jieqiong Qiu, Jonathan A. Fletcher, Wen-Bin Ou
Published 2020-09-01

p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors.

by Joern Henze, Thomas Mühlenberg, Susanne Simon, Florian Grabellus, Brian Rubin, Georg Taeger, Martin Schuler, Juergen Treckmann, Maria Debiec-Rychter, Takahiro Taguchi, Jonathan A Fletcher, Sebastian Bauer
Published 2012-01-01

Gastrointestinal Stromal Tumours: Etiology, Pathology and Clinical Management

by Martin E Blackstein, Pierre Dubé, Jonathan A Fletcher, Oliver R Keller, Margaret Knowling, Richard Létourneau, Donald Morris, Robert Riddell, Stewart Rorke, Carol J Swallow, Canadian Advisory Committee on GIST
Published 2004-01-01

Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.

by Yujiro Hayashi, David T Asuzu, Simon J Gibbons, Kirsten H Aarsvold, Michael R Bardsley, Gwen A Lomberk, Angela J Mathison, Michael L Kendrick, K Robert Shen, Takahiro Taguchi, Anu Gupta, Brian P Rubin, Jonathan A Fletcher, Gianrico Farrugia, Raul A Urrutia, Tamas Ordog
Published 2013-01-01

Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors

by César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde, Jordi Rosell, Jonathan A. Fletcher, Suzanne George, Joan Carles, Joaquín Arribas
Published 2020-02-01

Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis

by Miriam Magallón-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernández, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausová, Elisabeth Castellanos, Ignacio Blanco, George DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Viktor Mautner, Lan Kluwe, Nancy Ratner, Margaret Wallace, Juana Fernández-Rodriguez, Conxi Lázaro, Jonathan A. Fletcher, David Reuss, Meritxell Carrió, Bernat Gel, Eduard Serra
Published 2023-02-01

MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

by Inga-Marie Schaefer, Yuexiang Wang, Cher-wei Liang, Nacef Bahri, Anna Quattrone, Leona Doyle, Adrian Mariño-Enríquez, Alexandra Lauria, Meijun Zhu, Maria Debiec-Rychter, Susanne Grunewald, Jaclyn F. Hechtman, Armelle Dufresne, Cristina R. Antonescu, Carol Beadling, Ewa T. Sicinska, Matt van de Rijn, George D. Demetri, Marc Ladanyi, Christopher L. Corless, Michael C. Heinrich, Chandrajit P. Raut, Sebastian Bauer, Jonathan A. Fletcher
Published 2017-03-01

Profiling critical cancer gene mutations in clinical tumor samples.

by Laura E MacConaill, Catarina D Campbell, Sarah M Kehoe, Adam J Bass, Charles Hatton, Lili Niu, Matt Davis, Keluo Yao, Megan Hanna, Chandrani Mondal, Lauren Luongo, Caroline M Emery, Alissa C Baker, Juliet Philips, Deborah J Goff, Michelangelo Fiorentino, Mark A Rubin, Kornelia Polyak, Jennifer Chan, Yuexiang Wang, Jonathan A Fletcher, Sandro Santagata, Gianni Corso, Franco Roviello, Ramesh Shivdasani, Mark W Kieran, Keith L Ligon, Charles D Stiles, William C Hahn, Matthew L Meyerson, Levi A Garraway
Published 2009-11-01

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples.

by Laura E. MacConaill, Catarina D. Campbell, Sarah M. Kehoe, Adam J. Bass, Charles Hatton, Lili Niu, Matt Davis, Keluo Yao, Megan Hanna, Chandrani Mondal, Lauren Luongo, Caroline M. Emery, Alissa C. Baker, Juliet Philips, Deborah J. Goff, Michelangelo Fiorentino, Mark A. Rubin, Kornelia Polyak, Jennifer Chan, Yuexiang Wang, Jonathan A. Fletcher, Sandro Santagata, Gianni Corso, Franco Roviello, Ramesh Shivdasani, Mark W. Kieran, Keith L. Ligon, Charles D. Stiles, William C. Hahn, Matthew L. Meyerson, Levi A. Garraway
Published 2009-01-01

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples.

by Laura E. MacConaill, Catarina D. Campbell, Sarah M. Kehoe, Adam J. Bass, Charles Hatton, Lili Niu, Matt Davis, Keluo Yao, Megan Hanna, Chandrani Mondal, Lauren Luongo, Caroline M. Emery, Alissa C. Baker, Juliet Philips, Deborah J. Goff, Michelangelo Fiorentino, Mark A. Rubin, Kornelia Polyak, Jennifer Chan, Yuexiang Wang, Jonathan A. Fletcher, Sandro Santagata, Gianni Corso, Franco Roviello, Ramesh Shivdasani, Mark W. Kieran, Keith L. Ligon, Charles D. Stiles, William C. Hahn, Matthew L. Meyerson, Levi A. Garraway
Published 2010-01-01

DiversityGAN: Diversity-Aware Vehicle Motion Prediction via Latent Semantic Sampling

by Huang, Xin, McGill, Stephen G, DeCastro, Jonathan A, Fletcher, Luke, Leonard, John J, Williams, Brian C, Rosman, Guy
Published 2021

Comparative Gene Expression Profiling of Benign and Malignant Lesions Reveals Candidate Therapeutic Compounds for Leiomyosarcoma

by Edris, Badreddin, Fletcher, Jonathan A., West, Robert B., van de Rijn, Matt, Beck, Andrew H.
Published 2013

Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma

by Nakayama, Robert, Zhang, Yi-Xiang, Czaplinski, Jeffrey T., Anatone, Alex J., Sicinska, Ewa T., Fletcher, Jonathan A., Demetri, George D., Wagner, Andrew J.
Published 2016

The Protein Kinase C Inhibitor Enzastaurin Exhibits Antitumor Activity against Uveal Melanoma

by Wu, Xinqiang, Zhu, Meijun, Fletcher, Jonathan A., Giobbie-Hurder, Anita, Hodi, Frank Stephen
Published 2012

Inhibition of Bcl-2 family members sensitises soft tissue leiomyosarcomas to chemotherapy

by de Graaff, Marieke A, de Rooij, Marije A J, van den Akker, Brendy E W M, Gelderblom, Hans, Chibon, Fréderic, Coindre, Jean-Michel, Marino-Enriquez, Adrian, Fletcher, Jonathan A, Cleton-Jansen, Anne-Marie, Bovée, Judith V M G
Published 2017