Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation

by Lyndsey Sandow, Ajia Town, Michael C. Heinrich
Published 2024-01-01

Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor

by Sebastian Bauer, Suzanne George, Margaret von Mehren, Michael C. Heinrich
Published 2021-07-01

Clinical efficacy comparison of avapritinib with other tyrosine kinase inhibitors in gastrointestinal stromal tumors with PDGFRA D842V mutation: a retrospective analysis of clinica...

by Margaret von Mehren, Michael C. Heinrich, Hongliang Shi, Sergio Iannazzo, Raymond Mankoski, Saša Dimitrijević, Gerard Hoehn, Silvia Chiroli, Suzanne George
Published 2021-03-01

Correlation of minimal residual disease cell frequency with molecular genotype in patients with acute myeloid leukemia

by Corine J. Hess, Nicole Feller, Fedor Denkers, Angèle Kelder, Pauline A. Merle, Michael C. Heinrich, Amy Harlow, Johannes Berkhof, Gert J. Ossenkoppele, Quinten Waisfisz, Gerrit J. Schuurhuis
Published 2009-01-01

A multicenter, dose-finding, phase 1b study of imatinib in combination with alpelisib as third-line treatment in patients with advanced gastrointestinal stromal tumor

by Maria A. Pantaleo, Michael C. Heinrich, Antoine Italiano, Claudia Valverde, Patrick Schöffski, Giovanni Grignani, Anna K. L. Reyners, Sebastian Bauer, Peter Reichardt, Daniel Stark, Ghimja Berhanu, Ulrike Brandt, Tommaso Stefanelli, Hans Gelderblom
Published 2022-05-01

Survey of activated FLT3 signaling in leukemia.

by Ting-lei Gu, Julie Nardone, Yi Wang, Marc Loriaux, Judit Villén, Sean Beausoleil, Meghan Tucker, Jon Kornhauser, Jianmin Ren, Joan MacNeill, Steven P Gygi, Brian J Druker, Michael C Heinrich, John Rush, Roberto D Polakiewicz
Published 2011-04-01

Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment

by Shuai Ye, Dinara Sharipova, Marya Kozinova, Lilli Klug, Jimson D’Souza, Martin G. Belinsky, Katherine J. Johnson, Margret B. Einarson, Karthik Devarajan, Yan Zhou, Samuel Litwin, Michael C. Heinrich, Ronald DeMatteo, Margaret von Mehren, James S. Duncan, Lori Rink
Published 2021-01-01

Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene

by Valentina Indio, Annalisa Astolfi, Giuseppe Tarantino, Milena Urbini, Janice Patterson, Margherita Nannini, Maristella Saponara, Lidia Gatto, Donatella Santini, Italo F. do Valle, Gastone Castellani, Daniel Remondini, Michelangelo Fiorentino, Margaret von Mehren, Giovanni Brandi, Guido Biasco, Michael C. Heinrich, Maria Abbondanza Pantaleo
Published 2018-03-01

Patient-reported outcomes in individuals with advanced gastrointestinal stromal tumor treated with ripretinib in the fourth-line setting: analysis from the phase 3 INVICTUS trial

by Patrick Schöffski, Suzanne George, Michael C. Heinrich, John R. Zalcberg, Sebastian Bauer, Hans Gelderblom, César Serrano, Robin L. Jones, Steven Attia, Gina D’Amato, Ping Chi, Peter Reichardt, Claus Becker, Kelvin Shi, Julie Meade, Rodrigo Ruiz-Soto, Jean-Yves Blay, Margaret von Mehren
Published 2022-12-01

Outcomes of Late-Line Systemic Treatment in GIST: Does Sequence Matter?

by Prapassorn Thirasastr, Thomas L. Sutton, Cissimol P. Joseph, Heather Lin, Behrang Amini, Skye C. Mayo, Dejka Araujo, Robert S. Benjamin, Anthony P. Conley, John A. Livingston, Joseph Ludwig, Shreyaskumar Patel, Ravin Ratan, Vinod Ravi, Maria A. Zarzour, Elise F. Nassif Haddad, Michael S. Nakazawa, Xiao Zhou, Michael C. Heinrich, Neeta Somaiah
Published 2024-02-01

MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

by Inga-Marie Schaefer, Yuexiang Wang, Cher-wei Liang, Nacef Bahri, Anna Quattrone, Leona Doyle, Adrian Mariño-Enríquez, Alexandra Lauria, Meijun Zhu, Maria Debiec-Rychter, Susanne Grunewald, Jaclyn F. Hechtman, Armelle Dufresne, Cristina R. Antonescu, Carol Beadling, Ewa T. Sicinska, Matt van de Rijn, George D. Demetri, Marc Ladanyi, Christopher L. Corless, Michael C. Heinrich, Chandrajit P. Raut, Sebastian Bauer, Jonathan A. Fletcher
Published 2017-03-01

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

by Demetri, George Daniel, von Mehren, Margaret, Blanke, Charles D., Van Den Abbeele, Annick Diane, Eisenberg, Burton, Roberts, Peter J., Heinrich, Michael C., Tuveson, David A., Singer, Samuel, Janicek, Milos, Fletcher, Jonathan A., Silverman, Stuart George, Silberman, Sandra L., Capdeville, Renaud, Kiese, Beate, Peng, Bin, Dimitrijevic, Sasa, Druker, Brian J., Corless, Christopher, Fletcher, Christopher D.M., Joensuu, Heikki
Published 2017

Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA

by Beadling, Carol, Patterson, Janice, Justusson, Emily, Nelson, Dylan, Pantaleo, Maria A., Hornick, Jason L., Chacón, Matias, Corless, Christopher L., Heinrich, Michael C.
Published 2014