Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant

by Benjamin Korman, Jun Wei, Anne Laumann, Polly Ferguson, John Varga
Published 2016-01-01

The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma.

by Swati Bhattacharyya, Jun Wei, Denisa S Melichian, Jeffrey Milbrandt, Kazuhiko Takehara, John Varga
Published 2009-10-01

Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis

by Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte, John Varga
Published 2018-07-01

Adiponectin Deregulation in Systemic Autoimmune Rheumatic Diseases

by Neža Brezovec, Katja Perdan-Pirkmajer, Saša Čučnik, Snežna Sodin-Šemrl, John Varga, Katja Lakota
Published 2021-04-01

SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma

by Katia Corano Scheri, Xiaoyan Liang, Vidhi Dalal, I. Caroline Le Poole, John Varga, Tomoko Hayashida
Published 2022-11-01

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

by Swati Bhattacharyya, Wenxia Wang, Zenshiro Tamaki, Bo Shi, Anjana Yeldandi, Yasuhiro Tsukimi, Masashi Yamasaki, John Varga
Published 2018-10-01

A recrystallization heat-treatment to reduce deformation anisotropy of additively manufactured Inconel 718

by Nadia Kouraytem, John Varga, Behnam Amin-Ahmadi, Hadi Mirmohammad, Raphaël A. Chanut, Ashley D. Spear, Owen T. Kingstedt
Published 2021-01-01

Early stage lung cancer detection in systemic sclerosis does not portend survival benefit: a cross sectional study.

by Jeremy B Katzen, Kirtee Raparia, Rishi Agrawal, Jyoti D Patel, Alfred Rademaker, John Varga, Jane E Dematte
Published 2015-01-01

Perspective to precision medicine in scleroderma

by Kazuhiro Komura, Kazuhiro Komura, Koichi Yanaba, Jean-David Bouaziz, Ayumi Yoshizaki, Minoru Hasegawa, John Varga, Kazuhiko Takehara, Takashi Matsushita
Published 2024-01-01

Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis.

by Swati Bhattacharyya, Jennifer L Sargent, Pan Du, Simon Lin, Warren G Tourtellotte, Kazuhiko Takehara, Michael L Whitfield, John Varga
Published 2011-01-01

Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma

by Roberta G. Marangoni, Poulami Datta, Ananta Paine, Stacey Duemmel, Marc Nuzzo, Laura Sherwood, John Varga, Christopher Ritchlin, Benjamin D. Korman
Published 2022-10-01

Serum amyloid A is a marker for pulmonary involvement in systemic sclerosis.

by Katja Lakota, Mary Carns, Sofia Podlusky, Katjusa Mrak-Poljsak, Monique Hinchcliff, Jungwha Lee, Matija Tomsic, Snezna Sodin-Semrl, John Varga
Published 2015-01-01

Fibronectin EDA forms the chronic fibrotic scar after contusive spinal cord injury

by John G. Cooper, Su Ji Jeong, Tammy L. McGuire, Sripadh Sharma, Wenxia Wang, Swati Bhattacharyya, John Varga, John A. Kessler
Published 2018-08-01

Deficiency of inhibitory TLR4 homolog RP105 exacerbates fibrosis

by Wenxia Wang, Swarna Bale, Bharath Yalavarthi, Priyanka Verma, Pei-Suen Tsou, Ken M. Calderone, Dibyendu Bhattacharyya, Gary J. Fisher, John Varga, Swati Bhattacharyya
Published 2022-11-01

Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts.

by Michael E Johnson, J Matthew Mahoney, Jaclyn Taroni, Jennifer L Sargent, Eleni Marmarelis, Ming-Ru Wu, John Varga, Monique E Hinchcliff, Michael L Whitfield
Published 2015-01-01

PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis.

by Jun Wei, Asish K Ghosh, Jennifer L Sargent, Kazuhiro Komura, Minghua Wu, Qi-Quan Huang, Manu Jain, Michael L Whitfield, Carol Feghali-Bostwick, John Varga
Published 2010-11-01

Effect of Nintedanib on Progression of Systemic Sclerosis‐Associated Interstitial Lung Disease Over 100 Weeks: Data From a Randomized Controlled Trial

by Shervin Assassi, Oliver Distler, Yannick Allanore, Takashi Ogura, John Varga, Serena Vettori, Bruno Crestani, Florian Voss, Margarida Alves, Susanne Stowasser, Toby M. Maher, SENSCIS trial investigators
Published 2022-10-01

Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis

by Swarna Bale, Priyanka Verma, Bharath Yalavarthi, Scott Arthur Scarneo, Philip Hughes, M. Asif Amin, Pei-Suen Tsou, Dinesh Khanna, Timothy A.J. Haystead, Swati Bhattacharyya, John Varga
Published 2023-07-01

Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs

by Bo Shi, Asif Amin, Pranjali Dalvi, Wenxia Wang, Nicholas Lukacs, Li Kai, Paul Cheresh, Thais R. Peclat, Claudia C. Chini, Eduardo N. Chini, Wim van Schooten, John Varga
Published 2023-12-01

PLG nanoparticles target fibroblasts and MARCO+ monocytes to reverse multiorgan fibrosis

by Dan Xu, Swati Bhattacharyya, Wenxia Wang, Igal Ifergan, Ming-Yi Alice Chiang Wong, Daniele Procissi, Anjana Yeldandi, Swarna Bale, Roberta Goncalves Marangoni, Craig Horbinski, Stephen D. Miller, John Varga
Published 2022-03-01