Presenilins and γ-Secretase in Membrane Proteostasis

by Naoto Oikawa, Jochen Walter
Published 2019-03-01

The wish to cure and the curiosity to investigate - or how I used my life to become a physician-scientist

by Jochen Walter Ulrich Fries
Published 2015-03-01

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

by Sathish Kumar, Cynthia A. Lemere, Jochen Walter
Published 2020-07-01

Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt.

by Martin Siepmann, Sathish Kumar, Günter Mayer, Jochen Walter
Published 2010-10-01

Phosphorylation modifies the molecular stability of β-amyloid deposits

by Nasrollah Rezaei-Ghaleh, Mehriar Amininasab, Sathish Kumar, Jochen Walter, Markus Zweckstetter
Published 2016-04-01

Sphingosine-1-Phosphate: Boon and Bane for the Brain

by Gerhild van Echten-Deckert, Nadine Hagen-Euteneuer, Ilker Karaca, Jochen Walter
Published 2014-06-01

Novel Phosphorylation-State Specific Antibodies Reveal Differential Deposition of Ser26 Phosphorylated Aβ Species in a Mouse Model of Alzheimer’s Disease

by Sathish Kumar, Akshay Kapadia, Sandra Theil, Pranav Joshi, Florian Riffel, Michael T. Heneka, Michael T. Heneka, Jochen Walter
Published 2021-01-01

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.

by Christine M LaPash Daniels, Elizabeth Paffenroth, Elizabeth V Austin, Konstantin Glebov, Diana Lewis, Jochen Walter, Albee Messing
Published 2015-01-01

TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits

by Pranav Joshi, Florian Riffel, Sathish Kumar, Nàdia Villacampa, Sandra Theil, Samira Parhizkar, Christian Haass, Marco Colonna, Michael T. Heneka, Thomas Arzberger, Jochen Herms, Jochen Walter
Published 2021-10-01

Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function

by Marietta Fabiano, Naoto Oikawa, Anja Kerksiek, Jun-ichi Furukawa, Hirokazu Yagi, Koichi Kato, Ulrich Schweizer, Wim Annaert, Jongkyun Kang, Jie Shen, Dieter Lütjohann, Jochen Walter
Published 2024-05-01

A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis

by Kathleen Weisel, Scott Berger, Katie Thorn, Peter C. Taylor, Charles Peterfy, Hilary Siddall, Debra Tompson, Susanne Wang, Emilia Quattrocchi, Susan W. Burriss, Jochen Walter, Paul Peter Tak
Published 2021-03-01

Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer’s Disease and Control Mice

by Sandra den Hoedt, Simone M. Crivelli, Frank P. J. Leijten, Mario Losen, Jo A. A. Stevens, Marina Mané-Damas, Helga E. de Vries, Jochen Walter, Mina Mirzaian, Eric J. G. Sijbrands, Johannes M. F. G. Aerts, Adrie J. M. Verhoeven, Pilar Martinez-Martinez, Monique T. Mulder
Published 2021-10-01

FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer’s disease expressing APOE4

by Simone M. Crivelli, Qian Luo, Daan van Kruining, Caterina Giovagnoni, Marina Mané-Damas, Sandra den Hoedt, Dusan Berkes, Helga E. De Vries, Monique T. Mulder, Jochen Walter, Etienne Waelkens, Rita Derua, Johannes V. Swinnen, Jonas Dehairs, Erwin P.M. Wijnands, Erhard Bieberich, Mario Losen, Pilar Martinez-Martinez
Published 2022-08-01

Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

by Dietmar Rudolf Thal, Alicja Ronisz, Thomas Tousseyn, Ajeet Rijal Upadhaya, Karthikeyan Balakrishnan, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Markus Otto, Thomas G. Beach, Johan Lilja, Kerstin Heurling, Aruna Chakrabarty, Azzam Ismail, Christopher Buckley, Adrian P. L. Smith, Sathish Kumar, Gill Farrar, Jochen Walter
Published 2019-11-01

Correction to: Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

by Dietmar Rudolf Thal, Alicja Ronisz, Thomas Tousseyn, Ajeet Rijal Upadhaya, Karthikeyan Balakrishnan, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Markus Otto, Thomas G. Beach, Johan Lilja, Kerstin Heurling, Aruna Chakrabarty, Azzam Ismail, Christopher Buckley, Adrian P. L. Smith, Sathish Kumar, Gill Farrar, Jochen Walter
Published 2020-08-01

CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease

by Simone M. Crivelli, Qian Luo, Jo A.A. Stevens, Caterina Giovagnoni, Daan van Kruining, Gerard Bode, Sandra den Hoedt, Barbara Hobo, Anna-Lena Scheithauer, Jochen Walter, Monique T. Mulder, Christopher Exley, Matthew Mold, Michelle M. Mielke, Helga E. De Vries, Kristiaan Wouters, Daniel L. A. van den Hove, Dusan Berkes, María Dolores Ledesma, Joost Verhaagen, Mario Losen, Erhard Bieberich, Pilar Martinez-Martinez
Published 2021-02-01

Differences in treatment response between female and male psoriatic arthritis patients during IL-12/23 therapy with or without methotrexate: post hoc analysis of results from the r...

by Frank Behrens, Jürgen Rech, Jürgen Braun, Denis Poddubnyy, Gerd R Burmester, Uta Kiltz, Stephanie Finzel, Diamant Thaçi, Herbert Kellner, Karolina Benesova, Reinhard E Voll, Jan Brandt, Andrea Rubbert-Roth, David M Kofler, Klaus Krüger, Siegfried Wassenberg, Winfried Demary, Regina Max, Peter Kastner, Michaela Koehm, Ulrich von Hinüber, Raoul Bergner, Jan Brandt-Jürgens, Ann C Foldenauer, Tanja Rossmanith, Maren Sieburg, Rieke HE Alten, Arnd Kleye, David Kofler, Gabriele Lorenz, Holger Schwenke, Astrid Thiele, Jochen Walter
Published 2023-10-01