Massively parallel reporter assay confirms regulatory potential of hQTLs and reveals important variants in lupus and other autoimmune diseases

by Yao Fu, Jennifer A. Kelly, Jaanam Gopalakrishnan, Richard C. Pelikan, Kandice L. Tessneer, Satish Pasula, Kiely Grundahl, David A. Murphy, Patrick M. Gaffney
Published 2024-04-01

Familial Aggregation of High Tumor Necrosis Factor Alpha Levels in Systemic Lupus Erythematosus

by Dorothy Mangale, Silvia N. Kariuki, Beverly S. Chrabot, Marissa Kumabe, Jennifer A. Kelly, John B. Harley, Judith A. James, Kathy L. Sivils, Timothy B. Niewold
Published 2013-01-01

Systemic lupus erythematosus variants modulate the function of an enhancer upstream of TNFAIP3

by Satish Pasula, Jaanam Gopalakrishnan, Jaanam Gopalakrishnan, Yao Fu, Kandice L. Tessneer, Mandi M. Wiley, Richard C. Pelikan, Jennifer A. Kelly, Patrick M. Gaffney, Patrick M. Gaffney
Published 2022-09-01

Identification of unique microRNA signature associated with lupus nephritis.

by Jeannie L Te, Igor M Dozmorov, Joel M Guthridge, Kim L Nguyen, Joshua W Cavett, Jennifer A Kelly, Gail R Bruner, John B Harley, Joshua O Ojwang
Published 2010-05-01

Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis.

by Melissa E Munroe, Nathan Pezant, Michael A Brown, Dustin A Fife, Joel M Guthridge, Jennifer A Kelly, Graham Wiley, Patrick M Gaffney, Judith A James, Courtney G Montgomery
Published 2017-01-01

Effects of IRF5 Lupus Risk Haplotype on Pathways Predicted to Influence B Cell Functions

by Joel M. Guthridge, Daniel N. Clark, Amanda Templeton, Nicolas Dominguez, Rufei Lu, Gabriel S. Vidal, Jennifer A. Kelly, Kenneth M. Kauffman, John B. Harley, Patrick M. Gaffney, Judith A. James, Brian D. Poole
Published 2012-01-01

Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications...

by Miranda C. Marion, Paula S. Ramos, Prathyusha Bachali, Adam C. Labonte, Kip D. Zimmerman, Hannah C. Ainsworth, Sarah E. Heuer, Robert D. Robl, Michelle D. Catalina, Jennifer A. Kelly, Timothy D. Howard, Peter E. Lipsky, Amrie C. Grammer, Carl D. Langefeld
Published 2021-11-01

Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks

by Richard C. Pelikan, Jennifer A. Kelly, Yao Fu, Caleb A. Lareau, Kandice L. Tessneer, Graham B. Wiley, Mandi M. Wiley, Stuart B. Glenn, John B. Harley, Joel M. Guthridge, Judith A. James, Martin J. Aryee, Courtney Montgomery, Patrick M. Gaffney
Published 2018-07-01

Common variants within MECP2 confer risk of systemic lupus erythematosus.

by Amr H Sawalha, Ryan Webb, Shizhong Han, Jennifer A Kelly, Kenneth M Kaufman, Robert P Kimberly, Marta E Alarcón-Riquelme, Judith A James, Timothy J Vyse, Gary S Gilkeson, Chan-Bum Choi, R Hal Scofield, Sang-Cheol Bae, Swapan K Nath, John B Harley
Published 2008-03-01

Correction: Genome-Wide Association Study of African and European Americans Implicates Multiple Shared and Ethnic Specific Loci in Sarcoidosis Susceptibility.

by Indra Adrianto, Chee Paul Lin, Jessica J. Hale, Albert M. Levin, Indrani Datta, Ryan Parker, Adam Adler, Jennifer A. Kelly, Kenneth M. Kaufman, Christopher J. Lessard, Kathy L. Moser, Robert P. Kimberly, John B. Harley, Michael C. Iannuzzi, Benjamin A. Rybicki, Courtney G. Montgomery
Published 2013-01-01

Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility.

by Indra Adrianto, Chee Paul Lin, Jessica J Hale, Albert M Levin, Indrani Datta, Ryan Parker, Adam Adler, Jennifer A Kelly, Kenneth M Kaufman, Christopher J Lessard, Kathy L Moser, Robert P Kimberly, John B Harley, Michael C Iannuzzi, Benjamin A Rybicki, Courtney G Montgomery
Published 2012-01-01

Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort

by Rufei Lu, Julie M. Robertson, Benjamin F. Bruner, Joel M. Guthridge, Barbara R. Neas, Swapan K. Nath, Jennifer A. Kelly, Kathy L. Moser Sivils, Eliza F. Chakravarty, Diane L. Kamen, Gary S. Gilkeson, Daniel J. Wallace, Michael H. Weisman, R. Hal Scofield, John B. Harley, Judith A. James
Published 2012-01-01

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

by Lisa F Barcellos, Suzanne L May, Patricia P Ramsay, Hong L Quach, Julie A Lane, Joanne Nititham, Janelle A Noble, Kimberly E Taylor, Diana L Quach, Sharon A Chung, Jennifer A Kelly, Kathy L Moser, Timothy W Behrens, Michael F Seldin, Glenys Thomson, John B Harley, Patrick M Gaffney, Lindsey A Criswell
Published 2009-10-01

Relationship Between a Vitamin D Genetic Risk Score and Autoantibodies Among First-Degree Relatives of Probands With Rheumatoid Arthritis and Systemic Lupus Erythematosus

by Lauren A. Vanderlinden, Elizabeth A. Bemis, Jennifer Seifert, Joel M. Guthridge, Kendra A. Young, Mary Kristen Demoruelle, Marie Feser, Wade DeJager, Susan Macwana, Ted R. Mikuls, James R. O’Dell, Michael H. Weisman, Jane Buckner, Richard M. Keating, Patrick M. Gaffney, Jennifer A. Kelly, Carl D. Langefeld, Carl D. Langefeld, Kevin D. Deane, Judith A. James, Vernon Michael Holers, Jill M. Norris
Published 2022-06-01

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.

by Paula S Ramos, Lindsey A Criswell, Kathy L Moser, Mary E Comeau, Adrienne H Williams, Nicholas M Pajewski, Sharon A Chung, Robert R Graham, Raphael Zidovetzki, Jennifer A Kelly, Kenneth M Kaufman, Chaim O Jacob, Timothy J Vyse, Betty P Tsao, Robert P Kimberly, Patrick M Gaffney, Marta E Alarcón-Riquelme, John B Harley, Carl D Langefeld, International Consortium on the Genetics of Systemic Erythematosus
Published 2011-12-01

Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patientsResearch in context

by Judith A. James, Hua Chen, Kendra A. Young, Elizabeth A. Bemis, Jennifer Seifert, Rebecka L. Bourn, Kevin D. Deane, M. Kristen Demoruelle, Marie Feser, James R. O'Dell, Michael H. Weisman, Richard M. Keating, Patrick M. Gaffney, Jennifer A. Kelly, Carl D. Langefeld, John B. Harley, William Robinson, David A. Hafler, Kevin C. O'Connor, Jane Buckner, Joel M. Guthridge, Jill M. Norris, V. Michael Holers
Published 2019-04-01

Dysregulated long non-coding RNA in Sjögren’s disease impacts both interferon and adaptive immune responses

by Astrid Rasmussen, Kathy L Sivils, Joel M Guthridge, Judith A James, Jennifer A Kelly, Patrick M Gaffney, Jonathan D Wren, Stuart B Glenn, R Hal Scofield, Christopher J Lessard, Donald U Stone, David M Lewis, Lida Radfar, A Darise Farris, John A Ice, Courtney G Montgomery, Michelle L Joachims, Bhuwan Khatri, Chuang Li, Kandice L Tessneer, Anna M Stolarczyk, Nicolas Means, Kiely M Grundahl, Graham B Wiley, Indra Adrianto
Published 2022-12-01

Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus

by Prithvi Raj, Ran Song, Honglin Zhu, Linley Riediger, Dong-Jae Jun, Chaoying Liang, Carlos Arana, Bo Zhang, Yajing Gao, Benjamin E. Wakeland, Igor Dozmorov, Jinchun Zhou, Jennifer A. Kelly, Bernard R. Lauwerys, Joel M. Guthridge, Nancy J. Olsen, Swapan K. Nath, Chandrashekhar Pasare, Nicolai van Oers, Gary Gilkeson, Betty P. Tsao, Patrick M. Gaffney, Peter K. Gregersen, Judith A. James, Xiaoxia Zuo, David R. Karp, Quan-Zhen Li, Edward K. Wakeland
Published 2020-11-01

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

by Prithvi Raj, Ekta Rai, Ran Song, Shaheen Khan, Benjamin E Wakeland, Kasthuribai Viswanathan, Carlos Arana, Chaoying Liang, Bo Zhang, Igor Dozmorov, Ferdicia Carr-Johnson, Mitja Mitrovic, Graham B Wiley, Jennifer A Kelly, Bernard R Lauwerys, Nancy J Olsen, Chris Cotsapas, Christine K Garcia, Carol A Wise, John B Harley, Swapan K Nath, Judith A James, Chaim O Jacob, Betty P Tsao, Chandrashekhar Pasare, David R Karp, Quan Zhen Li, Patrick M Gaffney, Edward K Wakeland
Published 2016-02-01

The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

by Isaac T. W. Harley, Timothy B. Niewold, Rebecca M. Stormont, Kenneth M. Kaufman, Stuart B. Glenn, Beverly S. Franek, Jennifer A. Kelly, Jeffrey R. Kilpatrick, David Hutchings, Jasmin Divers, Gail R. Bruner, Jeffrey C. Edberg, Gerald McGwin, Michelle A. Petri, Rosalind Ramsey-Goldman, John D. Reveille, Luis M. Vilá-Pérez, Joan T. Merrill, Gary S. Gilkeson, Timothy J. Vyse, Marta E. Alarcón-Riquelme, Soo-Kyung Cho, Chaim O. Jacob, Graciela S. Alarcón, Kathy L. Moser, Patrick M. Gaffney, Robert P. Kimberly, Sang-Cheol Bae, Carl D. Langefeld, John B. Harley, Joel M. Guthridge, Judith A. James
Published 2010-01-01