Comparative analysis of the repertoire of insulin-reactive B cells in type 1 diabetes-prone and resistant mice

by Maureen Banach, Isaac T. W. Harley, Isaac T. W. Harley, Isaac T. W. Harley, Andrew Getahun, John C. Cambier
Published 2022-10-01

Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans

by Isaac T. W. Harley, Isaac T. W. Harley, Isaac T. W. Harley, Kristen Allison, Kristen Allison, R. Hal Scofield, R. Hal Scofield, R. Hal Scofield
Published 2022-08-01

Inhibitory Receptor Trap: A Platform for Discovery of Inhibitory Receptors That Utilize Inositol Lipid and Phosphotyrosine Phosphatase Effectors

by Bergren W. Crute, Rachel Sheraden, Vanessa L. Ott, Isaac T. W. Harley, Isaac T. W. Harley, Andrew Getahun, Andrew Getahun, John C. Cambier, John C. Cambier
Published 2020-10-01

Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between Sjögren’s Disease and Systemic Lupus Erythematosus

by Karen Chau, Yanint Raksadawan, Kristen Allison, John A. Ice, Robert Hal Scofield, Iouri Chepelev, Isaac T. W. Harley
Published 2023-09-01

Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis

by Valerie M. Harris, Valerie M. Harris, Kristi A. Koelsch, Kristi A. Koelsch, Biji T. Kurien, Isaac T. W. Harley, Isaac T. W. Harley, Jonathan D. Wren, John B. Harley, John B. Harley, John B. Harley, R. Hal Scofield, R. Hal Scofield, R. Hal Scofield
Published 2019-10-01

Magnetic Enrichment of SARS-CoV-2 Antigen-Binding B Cells for Analysis of Transcriptome and Antibody Repertoire

by Maureen Banach, Isaac T. W. Harley, Mary K. McCarthy, Cody Rester, Adonis Stassinopoulos, Ross M. Kedl, Thomas E. Morrison, John C. Cambier
Published 2022-02-01

Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21

by Valerie M. Harris, Valerie M. Harris, Valerie M. Harris, Valerie M. Harris, Isaac T. W. Harley, Isaac T. W. Harley, Biji T. Kurien, Biji T. Kurien, Biji T. Kurien, Kristi A. Koelsch, Kristi A. Koelsch, Kristi A. Koelsch, Robert Hal Scofield, Robert Hal Scofield, Robert Hal Scofield, Robert Hal Scofield, Robert Hal Scofield
Published 2019-04-01

The effect of inversion at 8p23 on BLK association with lupus in Caucasian population.

by Bahram Namjou, Yizhao Ni, Isaac T W Harley, Iouri Chepelev, Beth Cobb, Leah C Kottyan, Patrick M Gaffney, Joel M Guthridge, Kenneth Kaufman, John B Harley
Published 2014-01-01

Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction.

by Shizhong Han, Joel M Guthridge, Isaac T W Harley, Andrea L Sestak, Xana Kim-Howard, Kenneth M Kaufman, Bahram Namjou, Harshal Deshmukh, Gail Bruner, Luis R Espinoza, Gary S Gilkeson, John B Harley, Judith A James, Swapan K Nath
Published 2008-03-01

SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression

by Guojun Hou, Isaac T. W. Harley, Xiaoming Lu, Tian Zhou, Ning Xu, Chao Yao, Yuting Qin, Ye Ouyang, Jianyang Ma, Xinyi Zhu, Xiang Yu, Hong Xu, Dai Dai, Huihua Ding, Zhihua Yin, Zhizhong Ye, Jun Deng, Mi Zhou, Yuanjia Tang, Bahram Namjou, Ya Guo, Matthew T. Weirauch, Leah C. Kottyan, John B. Harley, Nan Shen
Published 2021-01-01

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain

by Calvin C. Chan, Isaac T. W. Harley, Paul T. Pfluger, Aurelien Trompette, Traci E. Stankiewicz, Jessica L. Allen, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, Jarren R. Oates, Pablo C. Alarcon, Jessica R. Doll, Matthew J. Flick, Leah M. Flick, Joan Sanchez-Gurmaches, Rajib Mukherjee, Rebekah Karns, Michael Helmrath, Thomas H. Inge, Stuart P. Weisberg, Sünje J. Pamp, David A. Relman, Randy J. Seeley, Matthias H. Tschöp, Christopher L. Karp, Senad Divanovic
Published 2021-05-01

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

by Bahram Namjou, Todd Lingren, Yongbo Huang, Sreeja Parameswaran, Beth L. Cobb, Ian B. Stanaway, John J. Connolly, Frank D. Mentch, Barbara Benoit, Xinnan Niu, Wei-Qi Wei, Robert J. Carroll, Jennifer A. Pacheco, Isaac T. W. Harley, Senad Divanovic, David S. Carrell, Eric B. Larson, David J. Carey, Shefali Verma, Marylyn D. Ritchie, Ali G. Gharavi, Shawn Murphy, Marc S. Williams, David R. Crosslin, Gail P. Jarvik, Iftikhar J. Kullo, Hakon Hakonarson, Rongling Li, The eMERGE Network, Stavra A. Xanthakos, John B. Harley
Published 2019-07-01

The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

by Isaac T. W. Harley, Timothy B. Niewold, Rebecca M. Stormont, Kenneth M. Kaufman, Stuart B. Glenn, Beverly S. Franek, Jennifer A. Kelly, Jeffrey R. Kilpatrick, David Hutchings, Jasmin Divers, Gail R. Bruner, Jeffrey C. Edberg, Gerald McGwin, Michelle A. Petri, Rosalind Ramsey-Goldman, John D. Reveille, Luis M. Vilá-Pérez, Joan T. Merrill, Gary S. Gilkeson, Timothy J. Vyse, Marta E. Alarcón-Riquelme, Soo-Kyung Cho, Chaim O. Jacob, Graciela S. Alarcón, Kathy L. Moser, Patrick M. Gaffney, Robert P. Kimberly, Sang-Cheol Bae, Carl D. Langefeld, John B. Harley, Joel M. Guthridge, Judith A. James
Published 2010-01-01