Human Brain Organoids to Decode Mechanisms of Microcephaly

by Elke Gabriel, Anand Ramani, Nazlican Altinisik, Jay Gopalakrishnan
Published 2020-05-01

Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids [version 2; peer review: 2 approved]

by Juan F. Quintana, Matthew C. Sinton, Jay Gopalakrishnan, Praveena Chandrasegaran, Agatha Nabilla Lestari
Published 2023-07-01

Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2

by Andrea Bieder, Gayathri Chandrasekar, Arpit Wason, Steffen Erkelenz, Jay Gopalakrishnan, Juha Kere, Isabel Tapia-Páez
Published 2023-05-01

DNA damage and repair: underlying mechanisms leading to microcephaly

by Jessica Honorato Ribeiro, Jessica Honorato Ribeiro, Nazlican Altinisik, Nicholas Rajan, Mieke Verslegers, Sarah Baatout, Sarah Baatout, Jay Gopalakrishnan, Roel Quintens
Published 2023-10-01

Plk1/Polo Phosphorylates Sas-4 at the Onset of Mitosis for an Efficient Recruitment of Pericentriolar Material to Centrosomes

by Anand Ramani, Aruljothi Mariappan, Marco Gottardo, Sunit Mandad, Henning Urlaub, Tomer Avidor-Reiss, Maria Riparbelli, Giuliano Callaini, Alain Debec, Regina Feederle, Jay Gopalakrishnan
Published 2018-12-01

Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice

by Tommaso Ceruti, Quintino Giorgio D’Alessandris, Roberta Frapolli, Jay Gopalakrishnan, Mariachiara Buccarelli, Marina Meroni, Liverana Lauretti, Lucia Ricci-Vitiani, Roberto Pallini, Massimo Zucchetti
Published 2022-09-01

Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila

by Jean-André Lapart, Marco Gottardo, Elisabeth Cortier, Jean-Luc Duteyrat, Céline Augière, Alain Mangé, Julie Jerber, Jérôme Solassol, Jay Gopalakrishnan, Joëlle Thomas, Bénédicte Durand
Published 2019-12-01

Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications

by Wei Liu, Paweł Stachura, Haifeng C. Xu, Nikkitha Umesh Ganesh, Fiona Cox, Ruifeng Wang, Karl S. Lang, Jay Gopalakrishnan, Dieter Häussinger, Bernhard Homey, Philipp A. Lang, Aleksandra A. Pandyra
Published 2020-02-01

Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling

by Derrick Lee, Ryan C. Gimple, Xujia Wu, Briana C. Prager, Zhixin Qiu, Qiulian Wu, Vikas Daggubati, Aruljothi Mariappan, Jay Gopalakrishnan, Matthew R. Sarkisian, David R. Raleigh, Jeremy N. Rich
Published 2023-01-01

B‑nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner

by Andreas Stein, Persefoni Hilken née Thomopoulou, Corazon Frias, Sina M. Hopff, Paloma Varela, Nicola Wilke, Arul Mariappan, Jörg-Martin Neudörfl, Alexey Yu Fedorov, Jay Gopalakrishnan, Benoît Gigant, Aram Prokop, Hans-Günther Schmalz
Published 2022-01-01

Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs

by Ting Xie, Adi Danieli-Mackay, Mariachiara Buccarelli, Mariano Barbieri, Ioanna Papadionysiou, Q. Giorgio D’Alessandris, Claudia Robens, Nadine Übelmesser, Omkar Suhas Vinchure, Liverana Lauretti, Giorgio Fotia, Roland F. Schwarz, Xiaotao Wang, Lucia Ricci-Vitiani, Jay Gopalakrishnan, Roberto Pallini, Argyris Papantonis
Published 2024-05-01

Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length

by Xiangdong Zheng, Anand Ramani, Komal Soni, Marco Gottardo, Shuangping Zheng, Li Ming Gooi, Wenjing Li, Shan Feng, Aruljothi Mariappan, Arpit Wason, Per Widlund, Andrei Pozniakovsky, Ina Poser, Haiteng Deng, Guangshuo Ou, Maria Riparbelli, Callaini Giuliano, Anthony A. Hyman, Michael Sattler, Jay Gopalakrishnan, Haitao Li
Published 2016-06-01

RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis

by Muhammad Farooq, Louise Lindbæk, Nicolai Krogh, Canan Doganli, Cecilie Keller, Maren Mönnich, André Brás Gonçalves, Srinivasan Sakthivel, Yuan Mang, Ambrin Fatima, Vivi Søgaard Andersen, Muhammad S. Hussain, Hans Eiberg, Lars Hansen, Klaus Wilbrandt Kjaer, Jay Gopalakrishnan, Lotte Bang Pedersen, Kjeld Møllgård, Henrik Nielsen, Shahid. M. Baig, Niels Tommerup, Søren Tvorup Christensen, Lars Allan Larsen
Published 2020-11-01