Estimating fetal exposure to the P‐gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome

by Olena Anoshchenko, Mark A. Milad, Jashvant D. Unadkat
Published 2021-09-01

Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells

by Yik Pui Tsang, Tianran Hao, Qingcheng Mao, Edward J. Kelly, Jashvant D. Unadkat
Published 2024-02-01

Adapting regulatory drug‐drug interaction guidance to design clinical pharmacokinetic natural product‐drug interaction studies: A NaPDI Center recommended approach

by Emily J. Cox, Allan E. Rettie, Jashvant D. Unadkat, Kenneth E. Thummel, Jeannine S. McCune, Mary F. Paine
Published 2022-02-01

The Impact of Inflammation on the In Vivo Activity of the Renal Transporters OAT1/3 in Pregnant Women Diagnosed with Acute Pyelonephritis

by Jhohann Richard de Lima Benzi, Patrícia Pereira dos Santos Melli, Geraldo Duarte, Jashvant D. Unadkat, Vera Lucia Lanchote
Published 2023-10-01

Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model

by Flavia Storelli, Mayur K. Ladumor, Xiaomin Liang, Yurong Lai, Paresh P. Chothe, Osatohanmwen J. Enogieru, Raymond Evers, Jashvant D. Unadkat
Published 2024-01-01

Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes

by Mayur K. Ladumor, Flavia Storelli, Xiaomin Liang, Yurong Lai, Osatohanmwen J. Enogieru, Paresh P. Chothe, Raymond Evers, Jashvant D. Unadkat
Published 2023-02-01

Author Correction: Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice

by Avinash K. Persaud, Matthew C. Bernier, Michael A. Massey, Shipra Agrawal, Tejinder Kaur, Debasis Nayak, Zhiliang Xie, Brenna Weadick, Ruchika Raj, Kasey Hill, Nicole Abbott, Arnav Joshi, Nadeen Anabtawi, Claire Bryant, Arpad Somogyi, Zobeida Cruz-Monserrate, Foued Amari, Vincenzo Coppola, Alex Sparreboom, Sharyn D. Baker, Jashvant D. Unadkat, Mitch A. Phelps, Rajgopal Govindarajan
Published 2023-06-01

Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice

by Avinash K. Persaud, Matthew C. Bernier, Michael A. Massey, Shipra Agrawal, Tejinder Kaur, Debasis Nayak, Zhiliang Xie, Brenna Weadick, Ruchika Raj, Kasey Hill, Nicole Abbott, Arnav Joshi, Nadeen Anabtawi, Claire Bryant, Arpad Somogyi, Zobeida Cruz-Monserrate, Foued Amari, Vincenzo Coppola, Alex Sparreboom, Sharyn D. Baker, Jashvant D. Unadkat, Mitch A. Phelps, Rajgopal Govindarajan
Published 2023-06-01