G 2 Retro as a two-step graph generative models for retrosynthesis prediction

by Ziqi Chen, Oluwatosin R. Ayinde, James R. Fuchs, Huan Sun, Xia Ning
Published 2023-05-01

Efficacy of quorum sensing and growth inhibitors alone and in combination against avian pathogenic Escherichia coli infection in chickens

by Yosra A. Helmy, Dipak Kathayat, Gary Closs, Jr, Katie Galgozy, James R. Fuchs, Gireesh Rajashekara
Published 2023-04-01

Identification of a Small Molecule Anti-biofilm Agent Against Salmonella enterica

by Jasmine Moshiri, Darpan Kaur, Chido M. Hambira, Jenna L. Sandala, Jacob A. Koopman, James R. Fuchs, John S. Gunn
Published 2018-11-01

Evaluation of Novel Quorum Sensing Inhibitors Targeting Auto-Inducer 2 (AI-2) for the Control of Avian Pathogenic Escherichia coli Infections in Chickens

by Yosra A. Helmy, Dipak Kathayat, Loic Deblais, Vishal Srivastava, Gary Closs, Robert J. Tokarski, Oluwatosin Ayinde, James R. Fuchs, Gireesh Rajashekara
Published 2022-06-01

Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir

by Stephanie M. Bester, Daniel Adu-Ampratwum, Arun S. Annamalai, Guochao Wei, Lorenzo Briganti, Bridget C. Murphy, Reed Haney, James R. Fuchs, Mamuka Kvaratskhelia
Published 2022-10-01

Evaluation of synergy between host and pathogen-directed therapies against intracellular Leishmania donovani

by M. Shamim Hasan Zahid, Monica M. Johnson, Robert J. Tokarski, II, Abhay R. Satoskar, James R. Fuchs, Eric M. Bachelder, Kristy M. Ainslie
Published 2019-08-01

Identification and Optimization of a Novel HIV‑1 Integrase Inhibitor

by Daniel Adu-Ampratwum, Yuhan Pan, Pratibha C. Koneru, Janet Antwi, Ashley C. Hoyte, Jacques Kessl, Patrick R. Griffin, Mamuka Kvaratskhelia, James R. Fuchs, Ross C. Larue
Published 2022-01-01

A new class of multimerization selective inhibitors of HIV-1 integrase.

by Amit Sharma, Alison Slaughter, Nivedita Jena, Lei Feng, Jacques J Kessl, Hind J Fadel, Nirav Malani, Frances Male, Li Wu, Eric Poeschla, Frederic D Bushman, James R Fuchs, Mamuka Kvaratskhelia
Published 2014-05-01

Novel anti-campylobacter compounds identified using high throughput screening of a pre-selected enriched small molecules library

by Anand eKumar, Mary eDrozd, Ruby ePina-Mimbela, Xiulan eXu, Yosra A Helmy, Janet eAntwi, James R Fuchs, Corey eNislow, Jillian eTempleton, Patrick J Blackall, Gireesh eRajashekara
Published 2016-04-01

Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.

by Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinski
Published 2012-01-01

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

by Pratibha C Koneru, Ashwanth C Francis, Nanjie Deng, Stephanie V Rebensburg, Ashley C Hoyte, Jared Lindenberger, Daniel Adu-Ampratwum, Ross C Larue, Michael F Wempe, Alan N Engelman, Dmitry Lyumkis, James R Fuchs, Ronald M Levy, Gregory B Melikyan, Mamuka Kvaratskhelia
Published 2019-05-01

Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

by Debasmita Mukherjee, Srija Chakraborty, Lena Bercz, Liliana D’Alesio, Jessica Wedig, Molly A. Torok, Timothy Pfau, Hannah Lathrop, Shrina Jasani, Abigail Guenther, Jake McGue, Daniel Adu-Ampratwum, James R. Fuchs, Timothy L. Frankel, Maciej Pietrzak, Stacey Culp, Anne M. Strohecker, Aleksander Skardal, Thomas A. Mace
Published 2023-08-01

PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer

by Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Published 2022-01-01

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

by Jianqiang Wu, Vincent W. Keng, Deanna M. Patmore, Jed J. Kendall, Ami V. Patel, Edwin Jousma, Walter J. Jessen, Kwangmin Choi, Barbara R. Tschida, Kevin A.T. Silverstein, Danhua Fan, Eric B. Schwartz, James R. Fuchs, Yuanshu Zou, Mi-Ok Kim, Eva Dombi, David E. Levy, Gang Huang, Jose A. Cancelas, Anat O. Stemmer-Rachamimov, Robert J. Spinner, David A. Largaespada, Nancy Ratner
Published 2016-03-01