Bring on the brequinar: an approach to enforce the differentiation of myeloid-derived suppressor cells

by Natalie K. Horvat, Gregory B. Lesinski
Published 2022-12-01

Mirage or long-awaited oasis: reinvigorating T-cell responses in pancreatic cancer

by Gregory B Lesinski, Bassel F El-Rayes, Michael Brandon Ware
Published 2020-07-01

The Potential of CAR T Cell Therapy in Pancreatic Cancer

by Mehmet Akce, Mohammad Y. Zaidi, Mohammad Y. Zaidi, Edmund K. Waller, Bassel F. El-Rayes, Gregory B. Lesinski
Published 2018-09-01

Combined IL6 and CCR2 blockade potentiates antitumor activity of NK cells in HPV-negative head and neck cancer

by Fan Yang, Chenyang Yuan, Fanghui Chen, Zhaohui S. Qin, Nicole C. Schmitt, Gregory B. Lesinski, Nabil F. Saba, Yong Teng
Published 2024-03-01

Modulation of the tumor microenvironment by armed vesicular stomatitis virus in a syngeneic pancreatic cancer model

by Sijia Tang, Lei Shi, Breona T. Luker, Channen Mickler, Bhavana Suresh, Gregory B. Lesinski, Daping Fan, Yuan Liu, Ming Luo
Published 2022-02-01

Short-Term Soy Bread Intervention Leads to a Dose-Response Increase in Urinary Isoflavone Metabolites and Satiety in Chronic Pancreatitis

by Jennifer H. Ahn-Jarvis, Daniel Sosh, Erin Lombardo, Gregory B. Lesinski, Darwin L. Conwell, Phil A. Hart, Yael Vodovotz
Published 2023-04-01

398 Utilizing a Th17 polarization strategy for generating high quality human TIL products for patients with advanced solid tumors

by Gregory B Lesinski, Keith A Delman, Chrystal M Paulos, Hannah M Knochelmann, Megan M Wyatt, Michael C Lowe, Soundharya Kumaresan
Published 2023-11-01

Intestinal Microbial Dysbiosis and Colonic Epithelial Cell Hyperproliferation by Dietary α-Mangostin is Independent of Mouse Strain

by Fabiola Gutierrez-Orozco, Jennifer M. Thomas-Ahner, Jeffrey D. Galley, Michael T. Bailey, Steven K. Clinton, Gregory B. Lesinski, Mark L. Failla
Published 2015-01-01

Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models

by Chrystal Paulos, Gregory B Lesinski, Zachary S Buchwald, Nabil F Saba, Vikash Kansal, Andre J Burnham, Brendan L C Kinney, Nicole C Schmitt
Published 2023-01-01

267 Adapting orthotopic murine models of pancreatic cancer to enhance adoptive T cell immunotherapy

by Gregory B Lesinski, Chrystal M Paulos, Cameron Herting, Maggie Phillips, Megan M Wyatt, Natalie K Horvat, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi
Published 2023-11-01

MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity.

by Mark Yarchoan, Aditya A Mohan, Lauren Dennison, Teena Vithayathil, Amanda Ruggieri, Gregory B Lesinski, Todd D Armstrong, Nilofer S Azad, Elizabeth M Jaffee
Published 2019-01-01

823 Repurposing CD26/DPP4 inhibitors to enhance immunotherapy response in pancreatic ductal adenocarcinoma

by Thomas Mace, Gregory B Lesinski, Chrystal M Paulos, Michael Ware, Olatunji Alese, Juan Sarmiento, Shishir Maithel, Maggie Phillips, Megan M Wyatt, Natalie K Horvat, Jacklyn Hammons, Bassel FEl Reyes
Published 2023-11-01

Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells.

by Jennifer Yang, Matthew A Bill, Gregory S Young, Krista La Perle, Yosef Landesman, Sharon Shacham, Michael Kauffman, William Senapedis, Trinayan Kashyap, Jean-Richard Saint-Martin, Kari Kendra, Gregory B Lesinski
Published 2014-01-01

PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).

by Courtney Nicholas, Jennifer Yang, Sara B Peters, Matthew A Bill, Robert A Baiocchi, Fengting Yan, Saïd Sïf, Sookil Tae, Eugenio Gaudio, Xin Wu, Michael R Grever, Gregory S Young, Gregory B Lesinski
Published 2013-01-01

Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo

by Hannah M. Komar, Gregory Serpa, Claire Kerscher, Erin Schwoegl, Thomas A. Mace, Ming Jin, Ming-Chen Yang, Ching-Shih Chen, Mark Bloomston, Michael C. Ostrowski, Phil A. Hart, Darwin L. Conwell, Gregory B. Lesinski
Published 2017-05-01

Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.

by Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinski
Published 2012-01-01

Phase II trial of nivolumab and metformin in patients with treatment-refractory microsatellite stable metastatic colorectal cancer

by Gregory B Lesinski, Christina Wu, Mehmet Akce, Brian Olson, Maria Diab, Batoul Farran, Jeffrey M Switchenko, Manali Rupji, Sandra Kang, Lana Khalil, Amanda Ruggieri-Joyce, Walid L Shaib, Olatunji B Alese, Bassel F El-Rayes
Published 2023-10-01

1507 The Galectin-9-Tim-3 pathway is a novel checkpoint target for patients with biliary tract cancer

by Yuan Liu, Gregory B Lesinski, Chrystal M Paulos, Shishir Maithel, Brian Robinson, Megan M Wyatt, Jacklyn Hammons, Emilie AK Warren, Jessica Keilson, Guillermo O Rangel-Rivera, Caroline R Goel, Curtis J Henry, Sarah Kulkarni, Alyssa Krasinskas
Published 2023-11-01

353 Adoptively transferred Th17 cells engage host B cells for durable tumor destruction

by Gregory B Lesinski, Chrystal M Paulos, Bhavana Pavuluri, Aubrey S Smith, Hannah M Knochelmann, Megan M Wyatt, Guillermo O Rangel Rivera, Amalia M Rivera-Reyes, Anna C Cole, Soundharya Kumaresan, Megen Wittling, Ayana T Ruffin, Jeremy M Boss
Published 2023-11-01

629 Neoadjuvant SEMA4D inhibitor pepinemab combination with nivolumab increases crosstalk between B cell and CD26hi T cell in patients with resectable stage III melanoma

by Brian Burns, Elizabeth Evans, Ragini Kudchadkar, Crystal Mallow, Christine Reilly, Maurice Zauderer, Gregory B Lesinski, Keith A Delman, Chrystal M Paulos, Brian Olson, Terrence Fisher, Jayden Kim, Michael C Lowe, Ayana T Ruffin, Jacklyn Hammons, Agnes Harutyunyan, Melinda Yushak, Ali Mokhtari, Douglas Parker
Published 2023-11-01