Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca2+ sensitizatio...

by Chung-Pin Liu, Jwu-Lai Yeh, Shu-Fen Liou, Bin-Nan Wu, Ing-Jun Chen
Published 2016-02-01

Restoration of uridine 5′-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cell...

by Zen-Kong Dai, Chang-Ling Kao, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu
Published 2016-12-01

KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways...

by Shu-Fen Liou, Jong-Hau Hsu, You-Ting Chen, Ing-Jun Chen, Jwu-Lai Yeh
Published 2015-06-01

KMUP-1 inhibits L-type Ca2+ channels involved the protein kinase C in rat basilar artery myocytes

by Jun-Yih Chen, Min-Chi Jiang, Li-Wen Chu, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu
Published 2011-12-01

Eugenosedin-A ameliorates hyperlipidemia-induced vascular endothelial dysfunction via inhibition of α1-adrenoceptor/5-HT activity and NADPH oxidase expression

by Kuo-Ping Shen, Hui-Li Lin, Wen-Tsan Chang, Jou-Chun Lin, Li-Mei An, Ing-Jun Chen, Bin-Nan Wu
Published 2014-03-01

KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes

by Chung-Pin Liu, Pei-Chun Chau, Chain-Ting Chang, Li-Mei An, Jwu-Lai Yeh, Ing-Jun Chen, Bin-Nan Wu
Published 2018-09-01

Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary art...

by Jiunn-Ren Wu, Li-Pin Kao, Bin-Nan Wu, Zen-Kong Dai, Yi-Ya Wang, Chee-Yin Chai, Ing-Jun Chen
Published 2015-05-01

Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent path...

by Chung-Pin Liu, Zen-Kong Dai, Chein-Heng Huang, Jwu-Lai Yeh, Bin-Nan Wu, Jiunn-Ren Wu, Ing-Jun Chen
Published 2014-06-01

KMUP-1 suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss: roles of MAPKs, Akt, NF-κB and calcium/calcineurin/NFATc1 pathways.

by Shu-Fen Liou, Jong-Hau Hsu, I-Ling Lin, Mei-Ling Ho, Pei-Chuan Hsu, Li-Wen Chen, Ing-Jun Chen, Jwu-Lai Yeh
Published 2013-01-01

Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice

by Bin-Nan Wu, Kung-Kai Kuo, Yu-Hsun Chen, Chain-Ting Chang, Hung-Tu Huang, Chee-Yin Chai, Zen-Kong Dai, Ing-Jun Chen
Published 2016-08-01

KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin

by Jwu-Lai Yeh, Chung-Pin Liu, Jong-Hau Hsu, Ching-Jiunn Tseng, Ping-Ju Wu, Yi-Ya Wang, Jiunn-Ren Wu, Ing-Jun Chen
Published 2012-11-01

ANTI-PROLIFERATIVE EFFECTIVENESS OF LERCANIDIPINE AND ITS MECHANISM OF ACTION (EXPERIMENTAL STUDY)

by Jiunn-Ren Wu, Shu-Fen Liou, Shin-Wha Lin, Chee-Yin Chai, Zen-Kong Dai, Jyh-Chong Liang, Ing-Jun Chen, Jwu-Lai Yeh
Published 2010-10-01

Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss[S]

by Kung-Kai Kuo, Bin-Nan Wu, Chung-Pin Liu, Tzu-Yang Yang, Li-Pin Kao, Jiunn-Ren Wu, Wen-Ter Lai, Ing-Jun Chen
Published 2015-11-01