Cinaciguat Prevents Postnatal Closure of Ductus Arteriosus by Vasodilation and Anti-remodeling in Neonatal Rats

by Yu-Chi Hung, Yu-Chi Hung, Yi-Ching Liu, Bin-Nan Wu, Bin-Nan Wu, Bin-Nan Wu, Jwu-Lai Yeh, Jwu-Lai Yeh, Jwu-Lai Yeh, Jwu-Lai Yeh, Jong-Hau Hsu, Jong-Hau Hsu
Published 2021-07-01

Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats

by Yu-Chi Cheng, Yu-Min Chiu, Zen-Kong Dai, Bin-Nan Wu
Published 2021-10-01

Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca2+ sensitizatio...

by Chung-Pin Liu, Jwu-Lai Yeh, Shu-Fen Liou, Bin-Nan Wu, Ing-Jun Chen
Published 2016-02-01

Restoration of uridine 5′-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cell...

by Zen-Kong Dai, Chang-Ling Kao, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu
Published 2016-12-01

Eugenosedin-A improves glucose metabolism and inhibits MAPKs expression in streptozotocin/nicotinamide-induced diabetic rats

by Kuo-Ping Shen, Hui-Li Lin, Hsueh-Wei Yen, Su-Ling Hsieh, Li-Mei An, Bin-Nan Wu
Published 2018-03-01

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca²⁺ Entry in Pulmonary Arterial Smooth Muscle Cells

by Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan Wu
Published 2024-03-01

KMUP-1 inhibits L-type Ca2+ channels involved the protein kinase C in rat basilar artery myocytes

by Jun-Yih Chen, Min-Chi Jiang, Li-Wen Chu, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu
Published 2011-12-01

Wheather green tea catechins could have a protective effect in overactive bladder rats induced by high-sugar high-fat diet and ovariectomy？

by Yi-Lun Lee, Wen-Chi Chen, Bin-Nan Wu, Shu-Mien Chuang, Wen-Jeng Wu, Yung-Shun Juan
Published 2016-06-01

Vasculoprotective effects of Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats

by Erna Sulistyowati, Ren-Long Jan, Shu-Fen Liou, Ying-Fu Chen, Bin-Nan Wu, Jong-Hau Hsu, Jwu-Lai Yeh
Published 2020-07-01

Eugenosedin-A ameliorates hyperlipidemia-induced vascular endothelial dysfunction via inhibition of α1-adrenoceptor/5-HT activity and NADPH oxidase expression

by Kuo-Ping Shen, Hui-Li Lin, Wen-Tsan Chang, Jou-Chun Lin, Li-Mei An, Ing-Jun Chen, Bin-Nan Wu
Published 2014-03-01

KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes

by Chung-Pin Liu, Pei-Chun Chau, Chain-Ting Chang, Li-Mei An, Jwu-Lai Yeh, Ing-Jun Chen, Bin-Nan Wu
Published 2018-09-01

In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis

by Shang-En Huang, Erna Sulistyowati, Yu-Ying Chao, Bin-Nan Wu, Zen-Kong Dai, Jong-Hau Hsu, Jwu-Lai Yeh
Published 2021-05-01

The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain

by Kuang-I Cheng, Yu-Chin Chang, Li-Wen Chu, Su-Ling Hsieh, Li-Mei An, Zen-Kong Dai, Bin-Nan Wu
Published 2022-12-01

Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition

by I-Chen Chen, I-Chen Chen, I-Chen Chen, Jao-Yu Lin, Yi-Ching Liu, Chee-Yin Chai, Jwu-Lai Yeh, Jwu-Lai Yeh, Jong-Hau Hsu, Jong-Hau Hsu, Bin-Nan Wu, Bin-Nan Wu, Zen-Kong Dai, Zen-Kong Dai, Zen-Kong Dai
Published 2021-02-01

Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor Ameliorate Metabolic Disorder and Obesity Induced Cardiomyocyte Injury and Mitochondrial Remodeling

by Shih-Jie Jhuo, Yi-Hsiung Lin, I-Hsin Liu, Tsung-Hsien Lin, Bin-Nan Wu, Kun-Tai Lee, Wen-Ter Lai
Published 2023-04-01

BK_Ca Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia

by Kuang-I Cheng, Kan-Ting Yang, Chien-Lun Kung, Yu-Chi Cheng, Jwu-Lai Yeh, Zen-Kong Dai, Bin-Nan Wu
Published 2021-04-01

Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation

by Yu-Chi Cheng, Li-Wen Chu, Jun-Yih Chen, Su-Ling Hsieh, Yu-Chin Chang, Zen-Kong Dai, Bin-Nan Wu
Published 2020-08-01

Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary art...

by Jiunn-Ren Wu, Li-Pin Kao, Bin-Nan Wu, Zen-Kong Dai, Yi-Ya Wang, Chee-Yin Chai, Ing-Jun Chen
Published 2015-05-01

Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent path...

by Chung-Pin Liu, Zen-Kong Dai, Chein-Heng Huang, Jwu-Lai Yeh, Bin-Nan Wu, Jiunn-Ren Wu, Ing-Jun Chen
Published 2014-06-01

KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways

by Meng-Luen Lee, Erna Sulistyowati, Jong-Hau Hsu, Bo-Yau Huang, Zen-Kong Dai, Bin-Nan Wu, Yu-Ying Chao, Jwu-Lai Yeh
Published 2019-04-01